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Max-Delbrück-Centrum für Molekulare Medizin (MDC)

Address Robert-Rössle-Straße 10
13125 Berlin
Deutschland

GERiT This institution in GERiT

13125 Berlin

Projects

Priority Programmes
- Current projects
  - Coordination Funds
    (Applicant Wolf, Susanne A. )
  - Deregulation of 3D genome structure in models of memory and learning disability
    (Applicant Pombo, Ph.D., Ana )
  - SPP 2395: Local and peripheral drivers of microglial diversity and function
    (Spokesperson Wolf, Susanne A. )
- Completed projects
Research Grants
- Current projects
- Completed projects
Research Units
- Current projects
- Completed projects
Research Fellowships
- Completed projects
Collaborative Research Centres
- Current projects
  - Engineering CAR T cells to better find and eradicate neuroblastoma
    (Project Heads Höpken, Uta Elisabeth ; Künkele-Langer, Annette )
  - Immune regulation of vascular rarefaction and diastolic myocardial remodeling
    (Project Heads Müller, Dominik N. ; Sawamiphak, Suphansa )
  - Inhibitory control of memory consolidation in primary somatosensory cortex
    (Project Heads Judkewitz, Ph.D., Benjamin ; Poulet, Ph.D., James F.A. )
  - SFB 1177: Molecular and Functional Characterization of Selective Autophagy
    (Spokesperson Dikic, Ivan )
  - SFB 1315: Mechanisms and disturbances in memory consolidation: From synapses to systems
    (Spokesperson Larkum, Matthew )
  - SFB 1404: FONDA - Foundations of Workflows for Large-Scale Scientific Data Analysis
    (Spokesperson Leser, Ulf )
  - SFB 1449: Dynamic Hydrogels at Biointerfaces
    (Spokesperson Haag, Rainer )
  - SFB 1470: Multilevel mechanistic characterisation of Heart Failure with Preserved Ejection Fraction - Towards a novel classification of HFpEF for targeted therapies
    (Spokespersons Gotthardt, Michael ; Pieske, Burkert )
  - SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
    (Spokesperson Eggert, Angelika )
  - Targeted phosphoproteomics-based prediction of drug responses to combinatorial treatment
    (Project Heads Blüthgen, Nils ; Selbach, Matthias )
  - Targeting MYCN multiprotein complexes in neuroblastoma with miniproteins
    (Project Heads Dörr, Jan ; Wanker, Erich E. )
- Completed projects
  - A cGMP signaling cascade controlling axonal branching and neuronal circuitry
    (Project Heads Rathjen, Fritz G. ; Schmidt, Hannes )
  - Aktivitäts-abhängige Regulation von neuralen Zelloberflächenproteinen und ihre Funktion bei der Synaptogenese: Funktionelle Charakterisierung von CALEB
    (Project Head Rathjen, Fritz G. )
  - Analyse von negativen Regulatoren des Wnt/ß-Catenin-Signalweges in vitro und in vivo
    (Project Heads Birchmeier, Walter ; Schäffer, Hans-Jörg )
  - Analysis of the spontaneous and induced immune response against tumors of the gastrointestinal tract
    (Project Heads Blankenstein, Thomas ; Willimsky, Gerald )
  - Antigenspezifische Aktivierung von Suppressorzellen durch repetitive Epitopoligomere
    (Project Heads Falk, Kirsten ; Rötzschke, Olaf )
  - Application of new genetic approaches to the study of ion channels and molecular components in the development of the auditory nervous system
    (Project Head Ibanez-Tallon, Ines )
  - Autophagic degradation of aggregated huntingtin: a systematic investigation of cellular components and potential pathway modifiers
    (Project Head Wanker, Erich E. )
  - Common genes required for normal mechanotransduction in touch and hearing
    (Project Heads Gross, Manfred ; Lewin, Ph.D., Gary Richard )
  - Core Facility Proteomics, service and collaboration within the SFB
    (Project Heads Klose, Joachim ; Mao, Lei ; Wanker, Erich E. )
  - Die Rolle des Interferon-y-Rezeptos für die Generierung von Tumorimmunität
    (Project Heads Blankenstein, Thomas ; Qin, Ph.D., Zhihai )
  - Die Rolle von TNF-Rezeptoren I und II bei zytokininduzierter Tumorabstoßung
    (Project Head Blankenstein, Thomas )
  - Dynamics of Genome Duplication Machines
    (Project Head Cardoso, Maria Cristina )
  - Entwicklung autochthoner Tumormodelle zur Analyse onkotherapeutischer Nukleinsäuren und Tumorabstoßungs- und Escapemechanismen
    (Project Heads Blankenstein, Thomas ; Willimsky, Gerald )
  - Functional and Structural Characterization of Heterotetrameric p97/ASPL complexes
    (Project Heads Heinemann, Udo ; Wanker, Erich E. )
  - Functions of c-Cbl and Hakai-based endocytic scaffolds in trafficking of cell surface receptors
    (Project Heads Birchmeier, Walter ; Selbach, Matthias )
  - Funktion des c-met-Rezeptors und seines Liganden in der Entwicklung des Nervensystems
    (Project Head Birchmeier, Carmen )
  - Funktion des Transkriptionsfaktors NKX6.1 bei der Motoneuronentwicklung
    (Project Head Sander, Maike )
  - Funktion und Struktur der Chemokinrezeptoren CXCR5 und CCR7
    (Project Heads Heinemann, Udo ; Lipp, Martin )
  - Genetische Analyse von Met und ErbB durch konditionelle Mutagenese in der Maus
    (Project Heads Birchmeier, Carmen ; Garratt, Alistair )
  - Gut microbiome in renoprotection
    (Project Heads Forslund-Startceva, Sofia ; Müller, Dominik N. ; Wilck, Nicola )
  - Herstellung und Haltung genetisch veränderter Mäuse
    (Project Heads Horak, Ivan ; Rohde, Elvira )
  - Klinische Studien zur Optimierung der lokalen Tiefenhyperthermie im Rahmen multimodaler Therapiekonzepte für das lokal fortgeschrittene und rezidivierte Rektumkarzinom
    (Project Heads Riess, Hanno ; Schlag, Peter Michael ; Walther, Wolfgang )
  - Kommunikation von Mikrogliazellen mit Astrozyten und Neuronen
    (Project Head Kettenmann, Helmut )
  - Konstruktion Nierenzellkarzinom-jspezifischer zytotoxischer T-Lymphozyten durch retroviralen T-Zellrezeptor-Gentransfer
    (Project Head Uckert, Wolfgang )
  - Mechanismen der Neuron-Glia-Kommunikation und deren Beeinflussung durch Plastizität im Barrel Cortex
    (Project Head Kettenmann, Helmut )
  - Mechanismen der Synapsenbildung im Säuger ZNS
    (Project Head Pfrieger, Frank W. )
  - Modular organisation of vesicle tethering to membranes: Analysis of structural features and regulation by protein palmitoylation
    (Project Heads Heinemann, Udo ; Veit, Michael )
  - Modulation der Funktion von CD4+ Effektor/Memory T-Zellen bei chronischen Autoimmunerkrankungen
    (Project Heads Lipp, Martin ; Müller, Gerd )
  - Modules involved in endosomal/lysosomal Ion homeostasis and function
    (Project Head Jentsch, Thomas J. )
  - Molecular and cellular mechanisms of myoblast fusion
    (Project Heads Birchmeier, Carmen ; Schmoranzer, Jan )
  - Molecular control of the development and function of primary and secondary sensory neurons
    (Project Head Birchmeier, Carmen )
  - Molecular mechanisms of PDE3A-mediated renoprotection
    (Project Heads Alenina, Ph.D., Natalia ; Bader, Michael ; Klußmann, Enno )
  - Molecular pathways in forebrain development and holoprosencephaly
    (Project Heads Hammes-Lewin, Annette E. ; Willnow, Thomas E. )
  - Nrg1 and ErbB receptors in Schwann cell development and myelination
    (Project Heads Birchmeier, Carmen ; Garratt, Alistair ; Müller, Thomas ; Wende, Hagen )
  - Physiologische Eigenschaften glialer Tumore
    (Project Head Kettenmann, Helmut )
  - Physiologische Eigenschaften glialer Tumore
    (Project Head Kettenmann, Helmut )
  - Proteintranslokation durch die ER-Membran von Hefen - Identifizierung von Translokationskomponenten
    (Project Head Hartmann, Enno )
  - Redirecting the antigen-specificity of polyclonal regulatory T cells to optimize their therapeutic efficacy and safety
    (Project Heads Fillatreau, Simon ; Scheffold, Alexander ; Uckert, Wolfgang )
  - Regulation der ß-Catenin-vermittelten Signaltransduktion durch Conductin und mSW13
    (Project Head Behrens, Jürgen )
  - Regulation of lmymphocyte effector/memory functions in the mucosal immune response
    (Project Heads Höpken, Uta Elisabeth ; Lipp, Martin )
  - Regulation von Apoptoseprozessen in epithelialen Zellen
    (Project Head Dörken, Bernd )
  - Renoprotective prostaglandin reductase 2 (PTGR2)
    (Project Heads Kreutz, Reinhold ; Panakova, Daniela )
  - Röntgenstrukturuntersuchungen zur Kofaktorrolle von Tissue Factor (Gewebsfaktor)
    (Project Head Muller, Yves André )
  - Scaffolding of mechanotransduction domains in migrating and non-migrating cells
    (Project Heads Hammes-Lewin, Annette E. ; Lewin, Ph.D., Gary Richard ; Poole, Kathryn )
  - SFB 366: Cellular Signal Recognition and Transduction
    (Spokesperson Reutter, Werner )
  - SFB 449: Structure and Function of Membrane Integral Receptors
    (Spokesperson Haucke, Ph.D., Volker )
  - SFB 507: The role of non-neuronal cells in neurological disease
    (Spokespersons Dirnagl, Ulrich ; Einhäupl, Karl M. )
  - SFB 515: Mechanisms of Developmental and Experience-Dependent Neural Plasticity
    (Spokesperson Menzel, Randolf )
  - SFB 577: Molecular Basis of Clinical Variability in Mendelian Disorders
    (Spokesperson Mundlos, Stefan )
  - SFB 618: Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems
    (Spokesperson Hammerstein, Peter )
  - SFB 633: Induction and Modulation of T cell Mediated Immune Responses in the Gastrointestinal Tract
    (Spokespersons Siegmund, Britta ; Zeitz, Martin )
  - SFB 650: Cellular Approaches for the Suppression of Unwanted Immune Reactions - From Bench to Bedside
    (Spokesperson Volk, Hans-Dieter )
  - SFB 665: Developmental Disturbances in the Nervous System
    (Spokesperson Rosenmund, Christian )
  - SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
    (Spokespersons Hofmann, Klaus Peter ; Spahn, Christian M. T. )
  - SFB 958: Scaffolding of Membranes: Molecular Mechanisms and Cellular Functions
    (Spokespersons Haucke, Ph.D., Volker ; Sigrist, Stephan J. )
  - SFB 1365: Renoprotection
    (Spokesperson Persson, Pontus Börje )
  - Signaltransduktion von Adhäsionsmolekülen und Expression von Metalloproteinasen
    (Project Head Haller, Hermann )
  - ß-Catenin (Armadillo) als Regulator von Signaltransduktionsprozessen
    (Project Head Behrens, Jürgen )
  - Structural and functional analysis of the dynamin module
    (Project Head Daumke, Oliver )
  - Structure and fuction of the mammalian mechanotransduction subunit SLP3
    (Project Heads Daumke, Oliver ; Lewin, Ph.D., Gary Richard )
  - Substrate recognition by the HRD-ubiquitin ligase
    (Project Heads Jarosch, Ernst ; Sommer, Thomas )
  - Targeting PDE3A for protecting from hypertension-induced chronic kidney disease
    (Project Heads Bähring, Sylvia ; Klußmann, Enno )
  - Thermosensibilisierung und Hitzeschockantwort nach kombinierter Hormon- und Hyperthermiebehandlung von Östrogenrezeptor-positiven Mammatumoren
    (Project Head Benndorf, Rainer )
  - The Role of Gap Junction Protein alpha 12 (Connexin 46.6) in CNS Myelination
    (Project Heads Hübner, Christoph ; Kettenmann, Helmut ; Uhlenberg, Birgit )
  - Thrombin als Stimulus und Modulator mikroglialer Aktivierung
    (Project Head Hanisch, Uwe-Karsten )
  - Transgenic Core Facility
    (Project Heads Birchmeier, Carmen ; Jerchow, Boris ; Michel, Geert ; Tarabykin, Victor ; Wende, Hagen )
  - Understanding the biological function of HEAT-repeat containing human proteins
    (Project Heads Andrade-Navarro, Ph.D., Miguel ; Wanker, Erich E. )
  - Veränderungen von Zell-Zell-Wechselwirkungen glialer Tumorzellen in vitro und in vivo nach retroviralem und Liposomalem Zytokin-Gentransfer
    (Project Head Reszka, Regina )
Clinical Research Units
- Current projects
  - Antibody target identification and novel diagnostics
    (Applicants Prüß, Harald ; Wanker, Erich E. )
  - KFO 5023: BECAUSE-Y Berlin Center for Diagnosing, Understanding and Treating Antibody(Y)-mediated Neurological Diseases
    (Spokesperson Endres, Matthias )
- Completed projects
CRC/Transregios
- Current projects
  - Inhibitory control of thermal perception in mouse posterior insular cortex
    (Project Head Poulet, Ph.D., James F.A. )
  - TRR 186: Molecular Switches: Spatio-temporal Control of Cellular Signal Transmission
    (Spokespersons Freund, Christian ; Nickel, Walter )
- Completed projects
  - Adoptive T cell therapy of tumors visualized by non-invasive in vivo imaging
    (Project Heads Blankenstein, Thomas ; Na, Il-Kang )
  - Analysis of the Coxsackievirus-Adenovirus-Receptor (CAR) in the Pathogenesis of Cardiomyopathies
    (Project Heads Gotthardt, Michael ; Poller, Wolfgang )
  - Central Tasks
    (Project Heads Blankenstein, Thomas ; Busch, Dirk ; Schendel, Ph.D., Dolores J. )
  - Control of microglial function by activation of neurotransmitter/-hormone receptors
    (Project Heads Kettenmann, Helmut ; Wolf, Susanne A. )
  - Core facility for the construction and characterization of T cell receptor gene-modified T lymphocytes
    (Project Heads Frankenberger, Bernhard ; Schendel, Ph.D., Dolores J. ; Uckert, Wolfgang )
  - Functional and structural alterations in hippocampal inhibitory innervation in mesial temporal lobe epilepsy
    (Project Heads Gloveli, Tengis ; Meier, Jochen )
  - Functional implications of selectively NF-kB/Rel- and IKK-mediated Gene Signatures in Hodgkin Lymphoma Cells and in Lymphomagenesis
    (Project Head Scheidereit, Claus )
  - Integrated Research Training Group
    (Project Heads Hanisch, Uwe-Karsten ; Kettenmann, Helmut )
  - Integrated Research Training Group
    (Project Heads Kammertoens, Thomas ; Nößner, Elfriede ; Uckert, Wolfgang )
  - Mechanisms and Consequences of ABF-1 and Id2-mediated Plasticity of the malignant Transformation of lymphoid Cells
    (Project Heads Dörken, Bernd ; Janz, Martin ; Mathas, Stephan )
  - Molecular Genetics of C/EBP mediated myeloid-lymphoid Plasticity
    (Project Heads Kowenz-Leutz, Elisabeth ; Leutz, Achim ; Scheller, Ph.D., Marina )
  - RNAi-based replacement of the endogenous by a therapeutic T cell receptor
    (Project Head Uckert, Wolfgang )
  - Targeting the secretory pathway in T cells to enhance the cytolytic efficiency in adoptive immunotherapy
    (Project Heads Höpken, Uta Elisabeth ; Rehm, Armin )
  - T cell receptor gene transfer in CD4+ and CD8+ T cells for adoptive therapy of renal cell carcinomas
    (Project Heads Nößner, Elfriede ; Uckert, Wolfgang )
  - The patho-physioligical Role of Lineage-specific Transcription Factors, PU.1 and C/EBPa, in Identity and Tumorigenesis of B lymphatic Neoplasias
    (Project Head Rosenbauer, Frank )
  - The Role of non-malignant B Cells and immature myeloid Cells in Development and Progression of sporadic B Cell Neoplasias and solid Tumors
    (Project Heads Blankenstein, Thomas ; Willimsky, Gerald )
  - Transcriptional Control of Follicular T Helper Cell (TFH) Differentiation by Notch- and bHLH Proteins
    (Project Heads Lipp, Martin ; Müller, Gerd )
  - Transgenic mice with a human T cell receptor repertoire
    (Project Head Blankenstein, Thomas )
  - TRR 3: Mesial Temporal Lobe Epilepsies
    (Spokespersons Elger, Christian E. ; Steinhäuser, Christian )
  - TRR 36: Principles and Applications of Adoptive T Cell Therapy
    (Spokesperson Blankenstein, Thomas )
  - TRR 43: The Brain as a Target of Inflammatory Processes
    (Spokesperson Heppner, Frank )
  - TRR 52: Transcriptional Programming of Individual T Cell Subsets
    (Spokesperson Schmitt, Edgar )
  - TRR 54: Growth and Survival, Plasticity and Cellular Interactivity of Lymphatic Malignancies
    (Spokesperson Dörken, Bernd )
WBP Return Grant
- Completed projects
  - Rückkehrstipendium
    (Applicant Mittnenzweig, Markus )
Research Training Groups
- Current projects
  - GRK 2260: BIOQIC - BIOphysical Quantitative Imaging Towards Clinical Diagnosis
    (Spokesperson Sack, Ingolf )
  - GRK 2318: Tight junctions and their proteins: molecular features and actions in health and disease
    (Spokesperson Schulzke, Jörg-Dieter )
  - GRK 2424: Computational Methods for Oncology: Towards Personalized Therapies in Cancer
    (Spokesperson Blüthgen, Nils )
- Completed projects
  - GRK 80: Model Studies of Structures, Properties and Recognition of Biologically Relevant Molecules at Atomic Level
    (Spokesperson Höhne, Wolfgang )
  - GRK 238: Mechanisms of Damage in CNS Disease - Application of Imaging Techniques
    (Spokesperson Heinemann, Uwe )
  - GRK 268: Dynamics and Evolution of Cellular and Macromolecular Systems
    (Spokesperson Heinrich, Reinhart )
  - GRK 331: Temperature-Dependent Effects in Therapy and Diagnosis
    (Spokesperson Felix, Roland )
  - GRK 426: Molecular Basis of Therapy
    (Spokesperson Birchmeier, Walter )
  - GRK 754: Myocardial Gene Expression und Function - Myocardial Hypertrophy
    (Spokesperson Regitz-Zagrosek, Vera )
  - GRK 865: Mechanisms of Vasoregulation
    (Spokesperson Kübler, Wolfgang )
  - GRK 1258: The Impact of Inflammation on Nervous System Function
    (Spokesperson Kettenmann, Helmut )
  - GRK 1558: Nonequilibrium Collective Dynamics in Condensed Matter and Biological Systems
    (Spokesperson Stark, Holger )
  - GRK 1772: Computational Systems Biology
    (Spokesperson Klipp, Edda )
Scientific Networks
- Completed projects
  - Mechanisms of generation and maintenance of immune tolerance in pregnancy
    (Applicant Herse, Florian )
International Research Training Groups
- Completed projects
  - GRK 1631: MyoGrad - International Research Training Group for Myology
    (Spokesperson Spuler, Simone )
  - GRK 2403: Dissecting and Reengineering the Regulatory Genome
    (Spokesperson Ohler, Uwe )
Clusters of Excellence
- Completed projects
  - EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
    (Spokesperson Schmitz, Dietmar )
Graduate Schools
- Completed projects
  - GSC 86: Berlin School of Mind and Brain
    (Spokespersons Pauen, Michael ; Villringer, Arno )
  - GSC 203: Berlin-Brandenburg School for Regenerative Therapies (BSRT)
    (Spokesperson Duda, Georg )
  - GSC 1091: Berlin School of Integrative Oncology (BSIO)
    (Spokespersons Na, Il-Kang ; Schmitt, Clemens A. )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2049: NeuroCure
    (Spokespersons Dirnagl, Ulrich ; Schmitz, Dietmar )
NFDI technical and methodological consortia
- Current projects
  - GHGA – German Human Genome-Phenome Archive
    (Spokesperson Stegle, Ph.D., Oliver )
  - NFDI4Health – National Research Data Infrastructure for Personal Health Data
    (Spokesperson Fluck, Juliane )
  - NFDI4Microbiota - National Research Data Infrastructure for Microbiota Research
    (Spokesperson Förstner, Konrad )

Subinstitutions

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