Zentralinstitut für Seelische Gesundheit
Klinik für Psychiatrie und Psychotherapie
Address
J 5
68159 Mannheim
Deutschland
GERiT
This institution in GERiT
68159 Mannheim
Projects
Emmy Noether Independent Junior Research Groups
Completed projects
Dimensional reconstruction of psychotic disorders through multimodal genetic-neural profiles
(Applicant
Schwarz, Ph.D., Emanuel
)
Neural mechanisms of planning and problem solving in prefrontal cortex
(Applicant
Durstewitz, Daniel
)
Wiring new neurons within adult brain circuits
(Applicant
Kelsch, Wolfgang
)
Research Grants
Current projects
Characterizing psychomotor dysfunction and related neural networks in schizophrenia and depression: a transdiagnostic systems neuroscience approach
(Applicants
Hirjak, Dusan
;
Schwarz, Ph.D., Emanuel
;
Wolf, Robert Christian
)
Delineating white matter phenotypes of psychomotor functioning in large-scale cohorts of healthy individuals and patients with psychiatric disorders across the life span
(Applicants
Hirjak, Dusan
;
Maier-Hein, Klaus
)
Distributed cortico-striatal computations underlying prediction learning in Pavlovian Markov processes
(Applicants
Kelsch, Wolfgang
;
Reinwald, Jonathan
)
Do antipsychotics induce dopaminergic supersensitivity in humans? A PET/MR study in patients with schizophrenia and healthy subjects
(Applicants
Gründer, Gerhard
;
Hirjak, Dusan
)
Semi-automatic tract dissection for tissue analysis and identification of microstructural white matter biomarkers of therapy outcome in catatonia
(Applicants
Hirjak, Dusan
;
Neher, Peter
)
Theoretical framework and bifurcation analysis for deep recurrent neural networks inferred from neural measurements
(Applicant
Durstewitz, Daniel
)
The role of pandemic and individual vulnerability in longitudinal cohorts across the life span: refined models of neurosociobehavioral pathways into substance (ab)use?
(Applicants
Banaschewski, Tobias
;
Flor, Herta
;
Nees, Frauke
;
Reis, Olaf
;
Schwarz, Ph.D., Emanuel
)
Completed projects
13C Magnetic Resonance Spectroscopy to Investigate the Effects of Chronic Alcohol Exposure on Neurometabolism in the In Vivo Mouse Brain
(Applicant
Sack, Markus
)
Anpassung neuronaler Dynamiken an kognitive Erfordernisse - Dopaminerge Kontrolle kortikaler Aktivitätsregime
(Applicant
Durstewitz, Daniel
)
Characterization of Neurodevelopmental Disease Trajectories using Richly Annotated Sequences of Graphs (RICHGRAPH)
(Applicants
Maier-Hein, Klaus
;
Tost, Heike
)
Delineating neural circuitry of STress REsilience and Stress Susceptibility using DREADD combined with fMRI technique (STRESS-DREADD)
(Applicant
Sartorius, Alexander
)
Designer receptors exclusively activated by designer drugs (DREADDs) used for endophenoptyping neuronal networks of depression by functional connectivity magnetic resonance imaging (fc-fMRI)
(Applicant
Sartorius, Alexander
)
Development, validation and application of an seizure quality index for the predicting of remission after electroconvulsive therapy.
(Applicant
Kranaster, Laura
)
Einfluss antidepressiver Therapie auf die Aktivität Stress-responsiver Systeme (Hypothalamus - Hypophysen - Nebennierenrinden (HHN) System und sympathoadrenerges System) - Verlaufsuntersuchung über 6 Monate
(Applicant
Deuschle, Michael
)
Inferring computational dynamics from neural measurements using deep recurrent neural networks
(Applicant
Durstewitz, Daniel
)
Interaktion von Hypothalamus-Hypophysen-Nebennierenrinden (HHN)-System und sympathoadrenergem System (Probandenstudie)
(Applicant
Deuschle, Michael
)
Metacognitive deficits in patients with at risk mental states for schizophrenia and their interaction with psychopathology, cognitive dysfunction and functional imaging
(Applicants
Kirsch, Peter
;
Meyer-Lindenberg, Andreas
;
Zink, Mathias
)
Neural correlates of stress-related gene-environment interactions
(Applicant
Laucht, Manfred
)
Neural stress processing and risk of coronary heart disease
(Applicants
Lederbogen, Florian
;
Meyer-Lindenberg, Andreas
)
Neurological soft signs as an external marker of neuronal dysfunction in schizophrenia: Investigation with multimodal magnetic resonance imaging
(Applicants
Hirjak, Dusan
;
Maier-Hein, Klaus
;
Wolf, Robert Christian
)
Neuropsychologische und familiengenetische Korrelate des Verlaufs der Schizophrenie und des schizotypen Verhaltens
(Applicant
Wagner, Ph.D., Michael
)
Ventral striatal processing of prefrontal inputs and phasic dopamine during rule switching
(Applicant
Bähner, Florian
)
Heisenberg Fellowships
Completed projects
Anpassung neuronaler Dynamiken an kognitive Erfordernisse - Dopaminerge Kontrolle kortikaler Aktivitätsregime
(Applicant
Durstewitz, Daniel
)
Heisenberg Professorships
Completed projects
Anpassung neuronaler Dynamiken an kognitive Erfordernisse - Dopaminerge Kontrolle kortikaler Aktivitätsregime
(Applicant
Durstewitz, Daniel
)
Research Units
Current projects
FOR 2591: Severity assessment in animal-based research
(Spokesperson
Bleich, André
)
FOR 5159: Resolving the prefrontal circuits of cognitive flexibility
(Spokesperson
Hanganu-Opatz, Ileana L.
)
Reconstructing neuro-dynamical principles of prefrontal cortical computations across cognitive tasks and species
(Applicant
Durstewitz, Daniel
)
Rodent models in psychiatry: severity assessment and potential measures for refinement and reduction
(Applicants
Gass, Peter
;
Mallien, Anne Stephanie
)
Major Research Instrumentation
Completed projects
3-Tesla MRT-System (Upgrade)
DNA-Workstation
Ganzkörper Hochfeld 3 Tesla MR-Tomograph
Upgrade eines 3-Tesla-MRT-Scanners
Clinical Research Units
Completed projects
Neural Mechanisms of Trust and Dyadic Interaction in BPD
(Applicants
Kirsch, Peter
;
Meyer-Lindenberg, Andreas
)
Neurobiological and Psychological Reaction Patterns in Response to Social Rejection in BPD
(Applicants
Bohus, Martin
;
Lis, Stefanie
)
Priority Programmes
Completed projects
Network Dynamics and Computational Mechanisms of Rule Learning II
(Applicants
Bähner, Florian
;
Durstewitz, Daniel
;
Hahn, Thomas Theodor Gerd
;
Kelsch, Wolfgang
)
The influence of thyroid hormones, receptors, and transporters on brain structure and function
(Applicants
Brabant, Georg
;
Münte, Thomas F.
;
Sartorius, Alexander
)
CRC/Transregios
Current projects
AI-based multi-modal data integration for prediction, mechanistic insight and subgroup stratification
(Project Heads
Durstewitz, Daniel
;
Koppe, Georgia
;
Schwarz, Ph.D., Emanuel
)
Decoding dynamic reciprocal neural mechanism underlying reactive aggression: Insights from fMRI and fNIRS hyperscanning
(Project Heads
Konrad, Kerstin
;
Meyer-Lindenberg, Andreas
;
Reindl, Vanessa
)
Distributed network control and interventions to frustrative non-reward and threat triggered aggressions
(Project Heads
Kelsch, Wolfgang
;
Weber-Fahr, Wolfgang
)
Early life stress and AUD: identifying neural and real-world targets for mechanism-based interventions
(Project Heads
Ebner-Priemer, Ulrich
;
Heim, Ph.D., Christine
;
Tost, Heike
)
Investigating psychological and neural correlates of intimate partner violence
(Project Heads
Bertsch, Ph.D., Katja
;
Meyer-Lindenberg, Andreas
;
Wagels, Lisa
)
Mobile infrastructure for daily life research
(Project Heads
Ebner-Priemer, Ulrich
;
Meyer-Lindenberg, Andreas
;
Stallkamp, Jan
)
Peripersonal space violations and social threat: daily life psychological and neural mechanisms of environmental risk for reactive aggression
(Project Heads
Meyer-Lindenberg, Andreas
;
Tost, Heike
)
Towards an integrative understanding of the impact of different types of discounting on decision making and its neural underpinnings in AUD
(Project Heads
Kirsch, Peter
;
Koppe, Georgia
;
Sommer, Wolfgang Heinrich
)
Research Fellowships
Completed projects
Neural mechanisms of working memory in the prefrontal cortex and their regulation by dopamine
(Applicant
Durstewitz, Daniel
)
Collaborative Research Centres
Current projects
Central data, project and analytics infrastructure
(Project Heads
Rupp, Rüdiger
;
Schwarz, Ph.D., Emanuel
;
Solinski, Hans Jürgen
;
Weidner, Norbert
)
Modulation of brain circuits underlying bidirectional interactions between pain and depression
(Project Heads
Magerl, Walter
;
Meyer-Lindenberg, Andreas
;
Treede, Rolf-Detlef
)
Social modulation of chronic pelvic pain: Neural inter-individual co-variation and partner interaction
(Project Heads
Bilek, Edda
;
Ditzen, Beate
;
Meyer-Lindenberg, Andreas
)
Towards a mechanism-specific intervention of thalamo-limbic pain processing
(Project Heads
Bilbao, Ainhoa
;
Spanagel, Rainer
;
Tesarz, Jonas
;
Tost, Heike
;
Weber-Fahr, Wolfgang
;
Wieland, Sebastian
)
Completed projects
Modulation of odour-entrained ensembles by phasic dopamine in the olfactory striatum
(Project Head
Kelsch, Wolfgang
)
Phasic dopamine-modulation of spike-timing-dependent plasticity and its implications for associative learning
(Project Heads
Durstewitz, Daniel
;
Kelsch, Wolfgang
)
Plasticity in prefrontal circuits in the human: Genetic variation, cellular mechanisms, and neurofeedback modulation
(Project Heads
Meyer-Lindenberg, Andreas
;
Rietschel, Marcella
;
Utikal, Jochen
)
Statistical characterization of cell ensembles in neuronal recordings
(Project Heads
Durstewitz, Daniel
;
Hamprecht, Fred A.
)
Research Training Groups
Completed projects
GRK 2350: Impact of adverse childhood experience on psychiatric and somatic disorders across the lifespan
(Spokesperson
Schmahl, Christian
)
International Research Training Groups
Completed projects
GRK 880: Vascular Medicine
(Spokesperson
Hammes, Hans-Peter
)
Clusters of Excellence (ExStra)
Current projects
EXC 2181: STRUCTURES: A unifying approach to emergent phenomena in the physical world, mathematics, and complex data
(Spokespersons
Klessen, Ph.D., Ralf
;
Oberthaler, Markus Kurt
;
Salmhofer, Manfred
;
Wienhard, Anna
)
