Universitätsklinikum Erlangen AöR
Medizinische Klinik 1
Gastroenterologie, Pneumologie und Endokrinologie
Address
Ulmenweg 18
91054 Erlangen
Deutschland
GERiT
This institution in GERiT
91054 Erlangen
Projects
Research Grants
Current projects
Characterization and function of OPA1 in intestinal epithelial homeostasis and the pathogenesis of inflammatory bowel disease
(Applicant
Becker, Christoph
)
Characterization of intestinal Amyloid Precursor Protein in the pathogenesis of colorectal cancer
(Applicant
Gamez Belmonte, Maria de los Reyes
)
Deciphering the role of stromal IL36R signalling for the resolution of intestinal inflammation and fibrosis
(Applicants
Koop, Kristina
;
Neufert, Ph.D., Clemens
)
Elucidating the Siglec-sialome axis of immune cell regulation with super-resolution microscopy and single-molecule/-particle tracking
(Applicant
Möckl, Leonhard
)
Exploring the impact of bacterial membrane vesicles on cholestatic liver diseases
(Applicant
Günther, Claudia
)
Molecular analysis of IL-9 producing Th9 cells in the context of Colitis-associated cancer (CAC)
(Applicant
Gerlach, Katharina
)
Regulation and function of the cholesterol biosynthesis inhibitors INSIG1 and INSIG2 in hepatocellular carcinoma
(Applicant
Dietrich, Ph.D., Peter
)
RhoA function in Intestinal Epithelial Cells as a key element in Colorectal Cancer
(Applicant
López Posadas, Ph.D., Rocío
)
Role of Epithelial Cell Death for Re-Establishment of the Gut Barrier During Resolution of Intestinal Inflammation
(Applicant
Becker, Christoph
)
T cell- and eosinophil-driven gut-lung interaction in the resolution of asthma
(Applicants
Finotto, Ph.D., Susetta
;
Zundler, Sebastian
)
Tec kinase ITK-dependent signaling pathways in the resolution of inflammation in ulcerative colitis
(Applicants
Neurath, Markus F.
;
Weigmann, Benno
)
The ATP Citrate Lyase (ACLY) as regulator of gut T cell immunometabolism in inflammatory bowel diseases.
(Applicant
Atreya, Ph.D., Imke
)
Thermographic endoscopic system for gastro intestinal tract imaging
(Applicant
Sharma, Ph.D., Gargi
)
Completed projects
(1-3)-beta-D-glucan guided early termination of antifungal therapy in ICU patients
(Applicant
Held, Jürgen
)
Cytokine gene transcription of IL-12 in IBD
(Applicant
Neurath, Markus F.
)
Development of antifibrotic therapies for chronic liver diseases
(Applicant
Dieterich, Walburga
)
Die Bedeutung der Vernetzung intrazellulärer Signalwege für die Regulation pankreatischer Beta-Zellen beim Diabetes mellitus Typ 2
(Applicant
Schöfl, Christof
)
Functional role of PGAM5 in epithelial homeostasis and colorectal cancer
(Applicant
Becker, Christoph
)
Gut Liver axis: The interrelated role of regulated ‐ necrosis as key driver of gastrointestinal and hepatic inflammation
(Applicants
Günther, Claudia
;
Kremer, Ph.D., Andreas Emanuel
)
Identification of molecular mechanisms of cholestatic pruritus
(Applicant
Kremer, Ph.D., Andreas Emanuel
)
IL-20-mediated suppression of pro-inflammatory epithelial STAT2 signaling in mucosal healing and inflammatory bowel disease
(Applicants
Chiriac, Mircea Teodor
;
Neurath, Markus F.
)
Impact of therapeutic α4β7 integrin inhibition on in vivo monocyte homing and intestinal wound healing in inflammatory bowel diseases
(Applicant
Zundler, Sebastian
)
Interaction between Batf3 dependent dendritic cells and the microbiota during experimental colitis
(Applicant
Hildner, Kai
)
Investigation of caspase-8 regulation and function in the development of colorectal cancer
(Applicant
Becker, Christoph
)
Isolierung und Charakterisierung des Gliadinrezeptors auf humanen Zelllinien - Untersuchung der Signalübertragung
(Applicant
Dieterich, Walburga
)
Molecular analysis of intestinal stem cells in the context of premature aging, chronic inflammation and colorectal carcinogenesis
(Applicant
Försch, Sebastian
)
Molecular investigations into the role of IL-36 receptor signaling for colorectal tumorigenesis
(Applicant
Neufert, Ph.D., Clemens
)
Molecular mechanisms of Rac1-mediated regulation of epithelial integrity in the inflamed gut
(Applicant
López Posadas, Ph.D., Rocío
)
Molekulare Analyse der funktionellen Bedeutung von Transkriptionsfaktoren der IRF-Familie bei chronisch entzündlichen Darmerkrankungen und Entzündungs-assoziierten Dickdarmtumoren
(Applicant
Mudter, Jonas
)
Molekulare Analyse der funktionellen Bedeutung von Transkriptionsfaktoren der NFAT-Familie bei Colitis-assoziiertem und sporadischem colorektalen Karzinom
(Applicant
Weigmann, Benno
)
Neuropeptides as effectors of immune cell activation in inflammatory bowel diseases
(Applicant
Engel, Matthias
)
Pathogenesis and Therapy of Ulcerative Colitis - From Sequence to Mechanisms
(Applicants
Becker, Christoph
;
Siegmund, Britta
)
Rolle der Transglutaminase (tTG) und tTG-spezifischer Antikörper in Pathogenese und Diagnostik der Zöliakie/Sprue und anderer Autoimmunerkrankungen
(Applicant
Dieterich, Walburga
)
Emmy Noether International Fellowships
Completed projects
Zytokinsignaltransduktion bei rheumatoider Arthritis
(Applicant
Hildner, Kai
)
Research Units
Current projects
FOR 2886: PANDORA - Pathways triggering AutoimmuNity and Defining Onset of early Rheumatoid Arthritis
(Spokesperson
Krönke, Gerhard
)
Completed projects
Analysis and functional modulation of the cross-talk between pSTAT3high cancer-associated fibroblasts and tumor cells in colorectal cancer
(Applicants
Neufert, Ph.D., Clemens
;
Neurath, Markus F.
)
Central project
(Applicants
Farin, Henner
;
Wirtz, Stefan
)
FOR 2438: Cell Plasticity in Colorectal Carcinogenesis
(Spokesperson
Greten, Florian R.
)
Functional role of Smad7 on intestinal epithelial homeostasis and colorectal cancer development
(Applicants
Becker, Christoph
;
Liebing, Eva
)
Intestinal epithelial cell death as modulator of intestinal dysbiosis, systemic autoimmunity and the onset of Arthritis
(Applicants
Bozec, Aline
;
Günther, Claudia
)
TH2 Zytokine in der Pathogenese des Colitis-assoziierten Colonkarzinoms: Molekulare und immuntoxikologische Untersuchungen
(Applicant
Wirtz, Stefan
)
The CXCL13-CXCR5 pathway as a regulator of adaptive immunity in colorectal cancer
(Applicant
Waldner, Ph.D., Maximilian
)
The functional role of VEGFR2-signaling in CD4+ T cells in the pathogenesis of colorectal cancer
(Applicant
Waldner, Ph.D., Maximilian
)
Clinical Research Units
Current projects
Deciphering immune interactions between human iPSC-derived enteric neural lineages and 3D intestinal epithelial organoids in mucosal inflammation
(Applicants
Neurath, Markus F.
;
Winner, Beate
)
Impact of intestinal myeloid cells on the immune-neuronal crosstalk in the pathogenesis of synucleinopathies and colitis
(Applicants
Hildner, Kai
;
Rothhammer, Veit
)
Impact of microbiota-brain communication on MS-related autoimmunity
(Applicants
Günther, Claudia
;
Rothhammer, Veit
)
Interplay between intestinal microbiome and multimodal MRI brain biosignatures for prediction of response to anti-TNF therapy in ulcerative colitis
(Applicants
Atreya, Raja
;
Dörfler, Arnd
)
KFO 5024: Immune checkpoints of gut to brain communication in inflammatory and neurodegenerative diseases (GB.Com)
(Spokesperson
Winner, Beate
)
Management and Administration of the collaborative research center
(Applicants
Gupta, Pooja
;
Günther, Claudia
)
Molecular mechanisms contributing to intestinal α-synuclein aggregation and pathology in Parkinson´s Disease
(Applicants
López Posadas, Ph.D., Rocío
;
Zunke, Friederike
)
Role of dysbiotic microbiota for immune cell neuronal communication in the pathogenesis of Parkinson disease
(Applicants
Winkler, Jürgen
;
Wirtz, Stefan
)
Role of enteric nervous system homeostasis in gut-nervous system immune signaling
(Applicants
Becker, Christoph
;
Lie, Dieter Chichung
)
Role of immune cell trafficking to the central nervous system for gut-brain communication in neurodegeneration
(Applicants
Prots, Iryna
;
Zundler, Sebastian
)
Completed projects
Analysis of the molecular mode of action of Cyclosporin A in inflammatory bowel disease
(Applicant
Weigmann, Benno
)
Characterization and expansion of regulatory T cells for cell-based therapy of Inflammatory bowel disease (IBD)
(Applicants
Bosch-Voskens, Ph.D., Caroline
;
Neurath, Markus F.
)
Cytokine mediated mechanisms In the immunopathogenesis of inflammatory bowel diseases
(Applicants
Becker, Christoph
;
Wirtz, Stefan
)
Functional characterization of prenylated Rho proteins in the pathogenesis of Inflammatory bowel diseases
(Applicant
Atreya, Ph.D., Imke
)
Immune regulation of angiogenesis in inflammatory bowel diseases
(Applicants
Stürzl, Michael
;
Waldner, Ph.D., Maximilian
)
In vivo endoscopic molecular imaging to predict therapeutic response to anti-adhesion molecule therapy in Crohn's disease patients
(Applicant
Atreya, Raja
)
KFO 257: Molecular Pathogenesis and Optimised Therapy of Inflammatory Bowel Diseases
(Spokesperson
Neurath, Markus F.
)
Koordination der Klinischen Forschungsgruppe 257
(Applicant
Becker, Christoph
)
Neuropeptides and TRP receptors as effectors of Immune cell activation In IBD
(Applicant
Engel, Matthias
)
Neutrophil extracellular traps orchestrate the immune response in Inflammatory Bowel Diseases
(Applicants
Herrmann, Martin
;
Leppkes, Moritz
)
Supportive project for the coordination of the Clinical Research Unit
(Applicant
Becker, Christoph
)
Priority Programmes
Completed projects
Impact of the intestinal microbiota and microbiota mediated immune responses on the host cell death machinery in the intestinal epithelium
(Applicant
Günther, Claudia
)
Mechanisms of microbiota induced IL-23/Th17 immune responses in chronic colitis
(Applicants
Neurath, Markus F.
;
Wirtz, Stefan
)
Modulation of the intestinal barrier by the intestinal microbiota - Role of dietetic factors and the mucosal immune system
(Applicant
Bischoff, Stephan
)
Molecular analysis of the immune-modulatory properties of colitogenic intestinal microbiota
(Applicant
Hildner, Kai
)
Piezo mechanosensitive receptor interplay with tight junction proteins for maintenance of epithelial cell number and integrity
(Applicant
López Posadas, Ph.D., Rocío
)
Heisenberg Professorships
Completed projects
Translational immunology in inflammatory bowel diseases
(Applicant
Atreya, Raja
)
Heisenberg Grants
Completed projects
Translationale Immunforschung bei chronisch-entzündlichen Darmerkrankungen
(Applicant
Atreya, Raja
)
Collaborative Research Centres
Completed projects
Analyse der pathogenetischen Bedeutung von Epstein-Barr viruinduced gene 3 (EBI3) und IL-27 bei der Persistenz bakteriell induzierter Entzündungsreaktionen
(Project Head
Neurath, Markus F.
)
Analyse der pathogenetischen Bedeutung von Epstein-Barr virus induced gene 3 (EBI-3) bei der Persistenz bakteriell induzierter intestinaler Entzündungsreaktionen
(Project Head
Neurath, Markus F.
)
Deciphering Batf-dependent and independent inflammatory and regulatory T cell programs at mucosal surfaces
(Project Head
Hildner, Kai
)
Einfluss von CTGF und Endostation auf die renale Angiogenese und Fibroplasie
(Project Heads
Bork, Jens Peter
;
Rascher, Wolfgang
;
Schuppan, Detlef
)
Functional analysis of bacterial Type VI effectors in EBI3-dependent regulation of enteric infection and inflammation
(Project Heads
Neurath, Markus F.
;
Wirtz, Stefan
)
Induktion einer Toleranz durch Identifizierung tolerogener T-Zellepitope bei der Sprue
(Project Head
Dieterich, Walburga
)
Integrated Research Training Group
(Project Heads
Koop, Kristina
;
Zaiss, Mario M.
)
Molecular analysis of TGF-beta signal transduction in the immunopathogenesis of sporadic and colitis associated colorectal cancer
(Project Head
Neurath, Markus F.
)
Molekulare Analyse der pathogenetischen Bedeutung von GATA-3 und NFAT-Tanskriptionsfaktoren bei chronisch entzündlichen Darmerkrankungen
(Project Head
Neurath, Markus F.
)
Regulation and Pathogenetic Relevance of the IL-28/IL-28R Signaling Pathway in Experimental Colitis and Inflammatory Bowel Diseases
(Project Heads
Neurath, Markus F.
;
Siebler, Juergen
)
Regulatory Networks that Control ILC2 Function in Acute and Chronic Inflammation
(Project Heads
Atreya, Ph.D., Imke
;
Wirtz, Stefan
)
Resolution of inflammation in anti-TNF treatment refractory intestinal inflammation
(Project Head
Atreya, Raja
)
Role of epithelial cell death for re-establishment of the gut barrier during resolution of intestinal inflammation
(Project Head
Becker, Christoph
)
T cell-driven gut-lung interaction in the resolution of asthma
(Project Heads
Finotto, Ph.D., Susetta
;
Zundler, Sebastian
)
Tec kinase ITK-dependent signaling pathways in the resolution of inflammation in ulcerative colitis
(Project Heads
Neurath, Markus F.
;
Weigmann, Benno
)
Untersuchung der TGF-beta vermittelten Induktion peripherer regulatorischer T-Zellen
(Project Head
Becker, Christoph
)
Viral regulators of cellular ripoptosome protein complex
(Project Heads
Becker, Christoph
;
Stürzl, Michael
)
Research Fellowships
Completed projects
Intestinal tissue-resident memory T cells as mediators of inflammatory bowel disease and possible targets of etrolizumab therapy
(Applicant
Zundler, Sebastian
)
Mechanisms of FcRn mediated intestinal inflammation
(Applicant
Rath, Timo
)
Molecular mechanisms in the interaction of lymphocytes and antigen presenting cells - Influence of hepatic stellate cells and myeolid suppressor cells on recruitment, transmigration and retention of lymphocytes in the chronically inflamed liver
(Applicant
Resheq, Yazid
)
Major Research Instrumentation
Completed projects
Konfokales Laserscanning-Mikroskop
MicroCT-Einheit
Multimodales Kleintier-Bildgebungsgerät
Multispektraler optoakustischer Tomograph
Tischdurchflusszytometer
CRC/Transregios
Current projects
Angiocrine signaling in metastatic colonisation of colon cancer
(Project Heads
Günther, Claudia
;
Naschberger, Elisabeth
)
A phase II multi-center clinical trial to study the efficacy and in vivo trafficking of autologous adoptively transferred ex vivo expanded regulatory T cells in patients with ulcerative colitis
(Project Heads
Bosch-Voskens, Ph.D., Caroline
;
Neurath, Markus F.
)
Central Tasks of the Collaborative Research Center
(Project Head
Becker, Christoph
)
Characterization of neuropeptide-receptor cross-talk driving metastatic liver colonization by disseminated cancer cells
(Project Heads
Bosserhoff, Anja-Katrin
;
Dietrich, Ph.D., Peter
)
Consequences of gut-imprinted immune cell trafficking for bone homeostasis
(Project Heads
Salbach-Hirsch, Juliane
;
Zundler, Sebastian
)
Direct and indirect crosstalk of epithelial GPR15L with immune cells via the intestinal microbiome in the pathogenesis of IBD
(Project Head
Zundler, Sebastian
)
Emergency barriers in Inflammatory Bowel Diseases- Neutrophil-epithelial interplay shapes epithelial restitution in the ulcer microenvironment
(Project Heads
Herrmann, Martin
;
Koop, Kristina
;
Leppkes, Moritz
)
Generation, molecular characteristics and effector mechanisms of CSF2+ T cells in graft-versus-host disease
(Project Head
Hildner, Kai
)
IBDome
(Project Heads
Atreya, Raja
;
Kühl, Anja A.
;
Trajanoski, Zlatko
)
Impact of epithelial dysfunction on neuro-immune crosstalk in IBD
(Project Heads
Becker, Christoph
;
Engel, Matthias
;
Klose, Christoph Siegfried Niki
;
Patankar, Ph.D., Jay
)
Inflammation-induced intestinal epithelial regulated necrosis as a novel modulator of bone resorption
(Project Heads
Bozec, Aline
;
Günther, Claudia
)
Integrated Research Training Group (iRTG)
(Project Heads
Atreya, Ph.D., Imke
;
Romagnani, Ph.D., Chiara
)
Label-free endoscopic analysis of immune-epithelial communication with advanced optical technologies
(Project Heads
Schürmann, Sebastian
;
Waldner, Ph.D., Maximilian
)
Mechanisms linking IFN-mediated mixed lineage kinase domain-like protein activation with intestinal inflammation
(Project Head
Günther, Claudia
)
Molecular and functional studies on the crosstalk between induced IELs and IECs in intestinal homeostasis and inflammation
(Project Heads
Hildner, Kai
;
Neufert, Ph.D., Clemens
)
Mucosal immunity as regulator of epithelial cell functions in inflammatory bowel diseases
(Project Heads
Becker, Christoph
;
Wirtz, Stefan
)
The Mevalonate pathway as a checkpoint for regulation of prenylation in intestinal epithelial cells in the context of inflammation
(Project Heads
Atreya, Ph.D., Imke
;
López Posadas, Ph.D., Rocío
)
Transcranial direct current stimulation for chronic, IBD-associated abdominal pain and the relation of pain perception and the intestinal epithelial barrier
(Project Heads
Atreya, Raja
;
Prüß, Magdalena S.
;
Schumann, Michael
)
TRR 241: Immune-Epithelial Communication in Inflammatory Bowel Diseases
(Spokesperson
Becker, Christoph
)
Completed projects
Molecular endoscopy to predict response to vedolizumab therapy in ulcerative colitis
(Project Heads
Atreya, Raja
;
Bojarski, Christian
)
Transcriptional Regulation and Pathogenetic Relevance of IL-28/IL-29 Cytokine System in Colitis and Colitis Associated Colon Carcinoma
(Project Heads
Neurath, Markus F.
;
Siebler, Juergen
)
Emmy Noether Independent Junior Research Groups
Current projects
Impact of immune cell trafficking for mucosal wound healing and intestinal inflammation in inflammatory bowel diseases
(Applicant
Zundler, Sebastian
)
Research Training Groups
Current projects
GRK 2599: FAIR - Fine-Tuners of the Adaptive Immune Response
(Spokespersons
Jäck, Hans-Martin
;
Zaiss, Mario M.
)
GRK 2740: Immunomicrotope: Microenvironmental, Metabolic and Microbial Signals Regulating Immune Cell-Pathogen Interactions
(Spokesperson
Bogdan, Christian
)
Completed projects
GRK 750: Vascular Injury in Heart and Kidney: Pathogenesis and Diagnostics
(Spokesperson
Goppelt-Strübe, Margarete
)
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
GRK 1660: Key Signals of Adaptive Immune Response
(Spokesperson
Jäck, Hans-Martin
)
GRK 1962: Dynamic Interactions at Biological Membranes - From Single Molecules to Tissue
(Spokesperson
Böckmann, Rainer
)
Graduate Schools
Completed projects
GSC 80: Erlangen Graduate School in Advanced Optical Technologies (SOAT)
(Spokesperson
Schmidt, Michael
)
