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Helmholtz-Zentrum für Infektionsforschung (HZI)

Address Inhoffenstraße 7
38124 Braunschweig
Deutschland

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38124 Braunschweig

Projects

Research Grants
- Current projects
- Completed projects
Research Units
- Current projects
- Completed projects
Priority Programmes
- Current projects
  - Phylogenomics of the genus Hypoxylon based on 50 new high quality genomes and with special emphasis on the H. rubiginosum complex
    (Applicants Cox, Russell J. ; Kalinowski, Jörn ; Stadler, Marc )
  - Single-cell RNA sequencing of multicellular communities
    (Applicant Häußler, Susanne )
- Completed projects
Collaborative Research Centres
- Current projects
  - SFB 1583: Decisions in Infectious Diseases (DECIDE)
    (Spokesperson Rudel, Thomas )
- Completed projects
  - Analyse und Modellierung intrazellulärer Energie-, Stoff- und Informationsflüsse für die Proteinbiosynthese
    (Project Head Deckwer, Wolf-Dieter )
  - Antiviral and antitumoral mechanisms of IRF-1 activity
    (Project Heads Hauser, Hansjörg ; Kröger, Andrea )
  - Aufarbeitung rekombinatner Proteine
    (Project Heads Deckwer, Wolf-Dieter ; Schwedes, Jörg )
  - Aufklärung der Mechanismen der Anheftung. Kolonisation und Penetration von Streptococcus pneumoniae in Lungenepithelzellen
    (Project Head Hammerschmidt, Sven )
  - Biofilm formation in response to fluctuating environmental conditions in Pseudomonas aeruginosa: a global genetic approach
    (Project Head Häußler, Susanne )
  - Characterization of the passage through the intestinal epithelium by Yersinia pseudotuberculosis during different stages of the infection
    (Project Head Dersch, Petra )
  - Charakterisierung von Glycosyltransferasen des Glucansucrasetyps und Modifizierung ihrer Substratspezifität
    (Project Head Hofer, Bernd )
  - Chemical functionalization of dental implant abutments for reduction of oral biofilm formation
    (Project Heads Abraham, Wolf-Rainer ; Menzel, Henning ; Stiesch, Meike )
  - Contribution of B cell subpopulations to gut-associated humoral immunity
    (Project Head Weiß, Siegfried )
  - Control of immunological synapse formation in Tregs
    (Project Heads Hühn, Jochen ; Jänsch, Lothar )
  - Control of the degradation and mode of action of magnesium-based medical implants
    (Project Heads Glasmacher, Birgit ; Hauser, Hansjörg ; Kietzmann, Manfred )
  - Die rolle von Interferon ß bei der Immunantwort gegen Krankheitserreger und der Aufrechterhaltung des immunologishen Gedächtnis
    (Project Head Weiß, Siegfried )
  - Dynamic imaging and modelling of the regulation of T cell - pathogen equilibration during chronic infection
    (Project Heads Meyer-Hermann, Michael ; Müller, Andreas )
  - Entwicklung und Testung neuer Strategien zur spezifischen Modulation des mukosalen Immunsystems
    (Project Heads Bruder, Dunja ; Buer, Jan )
  - Erzeugung, Screening und Charakterisierung modifizierter Glycosyltransferasen
    (Project Heads Buchholz, Klaus ; Hofer, Bernd )
  - Foxp3+ Tregs in mucosal tolerance: sites of de novo induction and stability under inflammatory conditions
    (Project Head Hühn, Jochen )
  - Functionalized Middle Ear Prostheses
    (Project Heads Behrens, Peter ; Jacob, Hans-Georg ; Lenarz, Thomas ; Müller, Peter Paul ; Stieve, Martin )
  - Generation of stable, alloantigen-specific Foxp3+ regulatory T-cells
    (Project Head Hühn, Jochen )
  - Generation of therapeutically effective stem cell transplants by targeted genome modification
    (Project Heads Cathomen, Toni ; Charpentier, Ph.D., Emmanuelle ; Schambach, Axel )
  - Genetische Analyse von Interleukin-10-produzierenden und auf Interleukin-10 antwortenden Zellen im darmassoziierten lymphatischen Gewebe
    (Project Head Müller, Werner )
  - Heterologe Expression von humanen Bone Morphogenetic Proteins in Escherichia coli
    (Project Head Gross, Gerhard )
  - Identification, isolation and molecular characterization of immunomodulatory cells
    (Project Heads Geffers, Ph.D., Robert ; Jaeckel, Elmar )
  - Implants surfaces
    (Project Heads Dempwolf, Wibke ; Gross, Gerhard ; Windhagen, Henning )
  - Induction of specific homing receptors and of regulatory properties in mucosal T cells
    (Project Heads Hamann, Alf ; Hühn, Jochen )
  - Mg-compounds on permanent implants
    (Project Heads Hauser, Hansjörg ; Möhwald, Kai ; Windhagen, Henning )
  - Molekulare Mechanismen der Reorganisation des Aktinzytoskeletts durch bakterielle Darmerreger
    (Project Heads Rottner, Klemens ; Wehland, Jürgen )
  - On-line Bioprozeßanalytik mit mikrostrukturierten Analysensystemen
    (Project Heads Bilitewski, Ursula ; Büttgenbach, Stephanus )
  - Rekrutierung von T-Zell-Subsets: Rolle von Antigen und Crosstalk mit Endothel
    (Project Heads Hamann, Alf ; Hühn, Jochen )
  - SFB 566: Cytokine Receptors and Cytokine-Dependent Signal Paths as Therapeutic Target Structures
    (Spokesperson Welte, Karl )
  - SFB 578: Development of Biotechnological Processes by Integrating Genetic and Engineering Methods - From Gene to Product
    (Spokesperson Jahn, Dieter )
  - SFB 587: Immunreactions of the Lung in Infection and Allergies
    (Spokespersons Hansen, Gesine ; Pabst, Reinhard )
  - SFB 599: Sustainable Bioresorbable and Permanent Implants of Metallic and Ceramic Materials
    (Spokesperson Lenarz, Thomas )
  - SFB 621: Pathobiology of the Intestinal Mucosa
    (Spokesperson Förster, Reinhold )
  - SFB 738: Optimisation of Conventional and Innovative Transplants
    (Spokespersons Ganser, Arnold ; Manns, Michael Peter )
  - SFB 854: Molecular Organisation of Cellular Communications within the Immune System
    (Spokesperson Schraven, Burkhart )
  - SFB 900: Chronic Infections: Microbial Persistence and its Control
    (Spokesperson Schulz, Thomas )
  - Spatiotemporal and cellular requirements for the regulation of T cell responses by type-I interferon
    (Project Heads Kalinke, Ulrich ; Schüler, Thomas )
  - Structual biology of glycosyltransferases for the optimisation of biotechnical processes
    (Project Heads Heinz, Dirk ; Seibel, Jürgen )
  - Studies on immune regulation in acute and chronic CD4+ T cell-mediated pulmonary disease
    (Project Head Bruder, Dunja )
  - Systembiologie der Produktbildung bei Bakterien
    (Project Heads Deckwer, Wolf-Dieter ; Franco-Lara, Ezequiel ; Hempel, Dietmar C. ; Jahn, Dieter )
  - Systems Biology of Product Formation by Aspergillus niger
    (Project Heads Jahn, Dieter ; Jänsch, Lothar ; Nörtemann, Bernd )
  - The Role of actin-based protrusions in 2D versus 3D cell migration
    (Project Head Stradal, Theresia )
  - The role of IFN-beta in inflammatory diseases: EAE as a model system
    (Project Head Weiß, Siegfried )
Research Fellowships
- Completed projects
  - Chemical grazing defense in biofilms and its molecular regulation the marine bacterium Pseudoalteromonas tunicata as a model organism
    (Applicant Matz, Carsten )
  - Synthetic approaches towards the next generation of photo-controlled antibiotics
    (Applicant Wegener, Michael )
Clinical Research Units
- Completed projects
  - Epigenetische Marker zur Quantifizierung von inflammatorischen und regulatorischen T-Zellen in Autoimmunpatienten
    (Applicants Hühn, Jochen ; Lochner, Matthias )
CRC/Transregios
- Current projects
  - Dynamics, epigenetic signatures and modulating factors of tissue Treg cell differentiation
    (Project Heads Delacher, Michael ; Hühn, Jochen )
  - Long-lasting consequences of early-life influenza A virus infection for the tissue-resident memory T cell niche and susceptibility to secondary infections
    (Project Heads Bruder, Dunja ; Hühn, Jochen )
  - TRR 298: Safety Integrated and Infection Reactive Implants
    (Spokesperson Stiesch, Meike )
  - TRR 359: Perinatal Development of Immune Cell Topology
    (Spokesperson Henneke, Philipp )
  - Uncovering of molecular mechanisms involved in biofilm-associated peri-implant infections
    (Project Heads Häußler, Susanne ; Stiesch, Meike )
- Completed projects
Research Training Groups
- Completed projects
  - GRK 705: Characterization of Pathophysiological Animal Models ? Functional and Genetic Analyses
    (Spokesperson Hedrich, Hans-Jürgen )
  - GRK 2223: Protein Complex Assembly (PROCOMPAS)
    (Spokesperson Mendel, Ralf R. )
International Research Training Groups
- Completed projects
  - GRK 653: Pseudomonas: Pathogenicity and Biotechnology
    (Spokesperson Tümmler, Burkhard )
  - GRK 1273: Strategies of Human Pathogens to Establish Acute and Chronic Infections
    (Spokesperson Suerbaum, Sebastian )
Clusters of Excellence
- Completed projects
  - EXC 62: From Regenerative Biology to Reconstructive Therapy (REBIRTH)
    (Spokespersons Haverich, Axel ; Thum, Ph.D., Thomas )
Graduate Schools
- Completed projects
  - GSC 108: Hannover Biomedical Research School (HBRS)
    (Spokesperson Schmidt, Reinhold Ernst )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2155: RESIST - Resolving Infection Susceptibility
    (Spokespersons Förster, Reinhold ; Hansen, Gesine ; Schulz, Thomas )
NFDI technical and methodological consortia
- Current projects
  - GHGA – German Human Genome-Phenome Archive
    (Spokesperson Stegle, Ph.D., Oliver )
  - National Research Data Infrastructure for Immunology
    (Spokesperson Busse, Christian )
  - NFDI4Microbiota - National Research Data Infrastructure for Microbiota Research
    (Spokesperson Förstner, Konrad )

Subinstitutions

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