TRR 167:  Development, function and potential of myeloid cells in the central nervous system (NeuroMac)

• Subject Area: Medicine
• Term: since 2017
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

No abstract available

• DFG Programme: CRC/Transregios
• International Connection: Israel, USA

Current projects

• A01 - Deciphering cellular interactions in CNS macrophage niches in mice and humans by spatial proteogenomics (Project Heads Amann, Lukas ;  Prinz, Marco )
• A02 - Monocyte-derived microglia and the impact of clonal hematopoiesis on the brain (Project Heads Jung, Ph.D., Steffen ;  Shlush, Ph.D., Liran )
• A03 - Massively parallel single-cell CRISPR screen for development of novel microglia targeting immunotherapies in Alzheimer's Disease (Project Heads Amit, Ph.D., Ido ;  Keren-Shaul, Hadas )
• A07 - How gut metabolites dictate CNS macrophages function in steady state, aging and neurodegeneration (Project Heads Blank, Thomas ;  Erny, Daniel )
• A09 - Mechanisms and consequences of microglia elimination during postnatal development (Project Heads Groß, Olaf ;  Kierdorf, Katrin )
• A11 - Decoding human microglia phenotypes in the context of neuropsychiatric disorders (Project Heads Priller, Josef ;  Schäfer, Simon )
• A12 - Metabolic regulation of macrophage function in the inflamed central nervous system (Project Heads Kerschensteiner, Martin ;  Misgeld, Thomas )
• B03 - The role of human endogenous retrovirus K as a modulator of microglial function in glioblastoma (Project Heads Lehnardt, Seija ;  Vincendeau, Michelle )
• B04 - Role of CNS-associated macrophages in mycobacterial meningoencephalitis (Project Heads Henneke, Philipp ;  Lößlein, Anne Kathrin )
• B05 - Association of myeloid cell and gut-derived B cell diversity with disease activity and severity in multiple sclerosis (Project Heads Böttcher, Chotima ;  Otto, Carolin ;  Priller, Josef )
• B06 - Deciphering the role of intestinal microbiome-derived metabolites on microglia activation during GVHD and ICANS (Project Heads Köhler, Natalie ;  Zeiser, Robert )
• B07 - Development and context-dependent plasticity of brain macrophages (Project Heads Priller, Josef ;  Prinz, Marco )
• B12 - Role of microglia in chronic inflammation and long-term consequences after stroke (Project Heads Meisel, Andreas ;  Meisel, Christian Alexander ;  Safaiyan, Shima )
• B14 - Impact of amyloid beta on microglia-mediated synaptic plasticity in the rodent and human cortex (Project Heads Meyer-Luehmann, Melanie ;  Vlachos, Andreas )
• B16 - USP18 as an immune check-point regulator for microglial activation (Project Heads Beling, Antje ;  Knobeloch, Klaus-Peter )
• INFZ01 - Bioinformatics and Modelling core (Project Heads Backofen, Rolf ;  Binder, Harald ;  Börries, Melanie ;  Gjorgjieva, Ph.D., Julijana )
• MGK - Integrated Research Training Group 'NeuroMac School' (Project Head Priller, Josef )
• Z02 - Central Tasks of the Collaborative Research Centre (Project Heads Priller, Josef ;  Prinz, Marco )

Completed projects

• A04 - Impact of proteostasis and the ubiquitin proteasome system on myeloid cell function in the CNS (Project Head Krüger, Elke Beate )
• A06 - The sequential phases of apoptotic cell clearance by microglia and macrophages (Project Heads Lämmermann, Ph.D., Tim ;  Rambold, Angelika )
• A08 - The NLRP3 inflammasome in CNS homeostasis and disease (Project Head Groß, Olaf )
• A10 - Importance of microglial tissue surveillance for neural development and function (Project Head Madry, Christian )
• B01 - Crosstalk of myeloid cells and neural stem cells during regeneration after stroke (Project Heads Fernández-Klett, Francisco ;  Schachtrup, Ph.D., Christian )
• B02 - Myeloid cells in the development of choroidal neovascularisation in the eye (Project Heads Hilgendorf, Ingo ;  Lange, Ph.D., Clemens A.K. )
• B09 - Probing myeloid effector functions in Alzheimer's disease and immunotherapy (Project Head Heppner, Frank )
• B10 - Microglial control of obesity and diabetes (Project Head Pospisilik, Ph.D., John Andrew )
• B11 - Function of C/EBPs in monocytes, macrophages and microglia (Project Heads Leutz, Achim ;  Schönheit, Jörg )
• B17 - Adrenergic regulation of myeloid cells in chronic inflammation and neurodegeneration (Project Head Klose, Christoph Siegfried Niki )
• B18 - Regulation of CNS Lupus by brain macrophages (Project Head Triantafyllopoulou, Antigoni )

• Applicant Institution: Technische Universität München (TUM)
• Co-Applicant Institution: Albert-Ludwigs-Universität Freiburg; Charité - Universitätsmedizin Berlin; Freie Universität Berlin; Humboldt-Universität zu Berlin
• Participating University: Ludwig-Maximilians-Universität München; Biomedizinisches Centrum München; Institut für Klinische Neuroimmunologie; Weizmann Institute of Science
• Spokespersons: Professor Dr. Josef Priller, since 1/2025; Professor Dr. Marco Prinz, until 12/2024