Universitätsklinikum Münster
Institut für Physiologische Chemie und Pathobiochemie
Address
Waldeyerstraße 15
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Research Fellowships
Completed projects
Differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase (NDST) isozymes 1-4 in the development of the mouse
(Applicant
Grobe, Kay
)
Research Grants
Current projects
Engineered Bacterial Coacervates
(Applicant
Di Iorio, Ph.D., Daniele
)
Light Controlled Designer Biofilms and Bacteriabots using Photoswitchable Bacterial Adhesions
(Applicant
Wegner, Seraphine
)
The role of direct heparan sulfate interactions and Ca2+ complexation in Hedgehog gradient formation in vivo
(Applicants
Grobe, Kay
;
Steffes, Georg
)
The role of extracellular ERp57/PDIA3 in healthy and osteoarthritic articular cartilage
(Applicant
Dreier, Rita
)
Completed projects
Effect of bifunctional venom-derived antagonists of platelet adhesion receptors (a2b1 integrin and GPIb) on platelet-supported hematogenous metastasis
(Applicant
Eble, Johannes Andreas
)
Functional Significance of the Basement Membrane in Leukocyte Extravasation in a Mouse Experimental Autoimmune Encephalomyelitis (EAE)
(Applicant
Sorokin, Lydia
)
Function of ERp57 in the development and progression of osteoarthritis in the knee joint
(Applicant
Dreier, Rita
)
HsP90 cochaperones Aha1 and Tpr2/Dnajc7 in Endoplasmic Reticulum associated protein quality control
(Applicant
Obermann, Wolfgang M.J.
)
In vivo function of differentially processed Hedgehog morphogens
(Applicant
Grobe, Kay
)
Lysosomes in Drosophila melanogaster: Characterization of key components and analysis of their impact for neuronal development.
(Applicant
Pohlmann, Regina
)
Mechanisms of Integrin α2β1 driven cell-matrix interaction in the course of bone regeneration and fracture healing
(Applicant
Stange, Richard
)
Parakrine Regulation der enchondralen Ossifikation
(Applicant
Bruckner, Peter
)
Physiologische Rolle von kollagenbindenden Integrinen auf Endothelzellen während der Angiogenese
(Applicant
Eble, Johannes Andreas
)
Processed Sonic hedgehog - an active signaling protease?
(Applicants
Grobe, Kay
;
Schilling, Oliver
)
Regulation der Hyaluronan-Synthese
(Applicant
Prehm, Peter
)
Regulation of macrophage dynamics and adipose stromal cells by laminins during adipose tissue remodelling in obesity
(Applicant
Sorokin, Lydia
)
Role and redox-regulation of integrins α2β1 on osteoclasts in differentiation and osteolysis
(Applicant
Eble, Johannes Andreas
)
Role of the gelatinases, MMP-2 and MMP-9, in cellular transmigration of basement membranes. The project deals with strategic cleavage of novel substrates by the gelatinases that are required for generation of a chemotactic gradient in inflamed tissues.
(Applicant
Sorokin, Lydia
)
Suprastructural specificity of integrin-mediated cell-matrix-interactions: Relation to cartilage homeostasis and osteoarthritis
(Applicants
Bruckner, Peter
;
Eble, Johannes Andreas
)
Syndecan-4 as a regulator of chondroblast development during fracture healing
(Applicant
Stange, Richard
)
The contribution of endothelial basement membrane laminins and immune cells to functional integrity of the neurovascular unit
(Applicant
Sorokin, Lydia
)
Untersuchung der rheumatischen Knorpelzerstörung mit Hilfe eines neu etablierten in vitro Modells (MATRIN-Assay) unter Verwendung von authentischen Kollagenmatrizes
(Applicant
Hansen, Uwe
)
Untersuchungen zum Transport der lysosomalen beta-Glucocerebrosidase
(Applicant
Pohlmann, Regina
)
Untersuchung von Giften südamerikanischer Schlangen und anderer Gifttiere auf Inhibitoren von kollagen- und lamininbindenden Integrinen
(Applicant
Eble, Johannes Andreas
)
Priority Programmes
Current projects
Adaptive Engineered Bacterial Coacervates
(Applicants
Di Iorio, Ph.D., Daniele
;
Philipp, Bodo
)
Completed projects
Functional characterization of Laminin 10
(Applicant
Sorokin, Lydia
)
Identification of alpha 1 beta 1 and alpha 2 beta 2 integrin recognition motifs within basement membrane ligands using phage display library screening, and their physiological effects on cells
(Applicant
Eble, Johannes Andreas
)
Thiol-based switches in integrins: molecular analysis and redox-regulatory implications in cell-matrix interaction and migration.
(Applicant
Eble, Johannes Andreas
)
Heisenberg Professorships
Completed projects
The role of the extracellular matrix constituent heparan sulfate in Hedgehog morphogen function
(Applicant
Grobe, Kay
)
Heisenberg Grants
Completed projects
Biological roles of heparan sulfate in Hedgehog-dependent signaling and morphogenetic gradient formation
(Applicant
Grobe, Kay
)
Collaborative Research Centres
Current projects
Adaptive Nanosystems: Principles and applications
(Project Heads
Rentmeister, Andrea
;
Salinga, Martin
;
Wegner, Seraphine
)
Dynamic and spatiotemporal control of Notch signaling for assembling precise multicellular structures
(Project Head
Wegner, Seraphine
)
Mechanisms and visualization of kidney injury-associated immunomodulatory responses affecting susceptibility to bacteria-induced pulmonary infection
(Project Heads
Block, Helena
;
Wegner, Seraphine
;
Zarbock, Alexander
)
Molecular parameters for the dynamic assembly of Hedgehog signaling platforms
(Project Head
Grobe, Kay
)
Multistimuli sensing with memory and feedback function using photoswitchable proteins
(Project Head
Wegner, Seraphine
)
Completed projects
Adhesive Interactions between Staphylococcus aureus and Matrix-Suprastructures as Determinants of Invasive Infections: the Role of Eap and Emp
(Project Heads
Bruckner, Peter
;
Löffler, Bettina
;
Peters, Georg
)
Bedeutung von Decorin und Fibromodulin für die entzündungsbedingte Angiogenese
(Project Head
Schönherr, Elke
)
Central Administration
(Project Head
Bruckner, Peter
)
Die Regulation der bildung von Fenestrierungen, Poren und Caveolae im Blutgefäßendothel der Niere: MECA-32 und FELS als Mitglieder einer neuen Proteinfamilie von Caveolae-assoziierten Molekülen
(Project Head
Hallmann, Rupert
)
Die Rolle des Gefäßwandendothels bei der Entwicklung von Entzündungsreaktionen
(Project Head
Hallmann, Rupert
)
Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum
(Project Head
Sorokin, Lydia
)
Entzündliche Gelenkserkrankungen: Parakrine Wechselwirkungen von Entzündungszellen mit Chondrozyten in vitro
(Project Head
Bruckner, Peter
)
Environmental Control of Chondrocyte Differentiation in Endochondral Ossification and Degenerative Joint Diseases
(Project Head
Dreier, Rita
)
Inhibition of Hyaluronan Export
(Project Head
Prehm, Peter
)
Interplay of cell adhesion and matrix proteolysis in barrier-braking invadopodia of tumor cells
(Project Head
Eble, Johannes Andreas
)
Mechanisms of leukocyte penetration of vascular cell basement membranes
(Project Head
Sorokin, Lydia
)
Mechanisms of Leukocyte Transmigration of Endothelial Cell Basement Membranes
(Project Head
Sorokin, Lydia
)
Nachwuchsgruppe des SFB 284
(Project Head
Obermann, Wolfgang M.J.
)
Redox-regulation of integrin-matrix contacts during cell adhesion and migration
(Project Head
Eble, Johannes Andreas
)
Roles of Heparan Sulfate in Sonic Hedgehog (Shh) Gradient Formation and Cardiac Development in the Mouse
(Project Head
Grobe, Kay
)
SFB 492: Extracellular Matrix: Biogenesis, Assembly and Cellular Interactions
(Spokesperson
Bruckner, Peter
)
Structural and Functional Characterisation of the Extracellular Matrix of the Spleen
(Project Head
Sorokin, Lydia
)
Structured training programs 'Master Experimental Medicine' and 'MedK'
(Project Heads
Hallmann, Rupert
;
Karch, Helge
)
Struktur, Stoffwechsel und Interaktionen von Dermatansulfat-Proteoglykanen der extrazellulären Matrix
(Project Head
Kresse, Hans
)
Suprastructure of the Extracellular Matrix: Macromolecular Alloys and Networks
(Project Head
Bruckner, Peter
)
Zelluläre Wechselwirkungen mit Laminin-5: Von der Integrinerkennung zur zellbiologischen Funktion
(Project Head
Eble, Johannes Andreas
)
CRC/Transregios
Completed projects
Molecular mechanisms and sites of action of the gelatinases in autoimmune CNS inflammation: do MMP-2/-9 contribute to meningeal inflammation and secondary cortical damage?
(Project Heads
Meyer zu Hörste, Gerd
;
Schäfers, Michael
;
Sorokin, Lydia
)
Physiological roles of collagen-binding integrins on endothelial cells in angiogenic sprouting and vessel integrity
(Project Head
Eble, Johannes Andreas
)
Clinical Research Units
Current projects
KFO 342: Organ Dysfuncion During Systemic Inflammation
(Spokesperson
Zarbock, Alexander
)
Role of Neuropilin-1 on Lung Macrophages during Pulmonary Inflammation
(Applicants
Eble, Johannes Andreas
;
Zarbock, Alexander
)
Research Training Groups
Completed projects
GRK 750: Vascular Injury in Heart and Kidney: Pathogenesis and Diagnostics
(Spokesperson
Goppelt-Strübe, Margarete
)
International Research Training Groups
Completed projects
GRK 1549: Molecular and Cellular Glyco-Sciences (MCGS). Understanding Structure/Function Relationships of Carbohydrate/Protein Interactions
(Spokesperson
Moerschbacher, Bruno
)
Clusters of Excellence
Completed projects
EXC 1003: Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms
(Spokesperson
Sorokin, Lydia
)
