SFB 1700:  Immune regulation in the liver: from homeostasis to disease

• Subject Area: Medicine ; Chemistry
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 530990199

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Autoaggressive CD4+ T cells participate in autoimmune liver disease (Project Head Gagliani, Ph.D., Nicola )
• A02 - Antigen-independent mechanisms determining tissue damage in liver autoimmunity (Project Heads Dudek, Michael ;  Knolle, Percy Alexander )
• A03 - The role of TNF in the regulation of hepatic autoimmunity (Project Heads Adlung, Lorenz ;  Herkel, Johannes )
• A04 - Dictating hepatic immune responses through bile acid-scavenging macrophages (Project Heads Bosurgi, Ph.D., Lidia ;  Worthmann, Anna )
• A05 - T cells and cholangiocytes: an interaction that governs portal immune regulation and determines biliary inflammation (Project Head Schwinge, Dorothee )
• A06 - The role of short expressed peptides and cell type composition in autoimmune liver inflamma-tion (Project Heads Hübner, Norbert ;  Schramm, Christoph )
• A07 - Using functional genomics to decipher the impact of polymorphisms in the IL2RA locus and other primary sclerosing cholangitis risk loci (Project Heads Ellinghaus, Ph.D., David ;  Huber, Samuel )
• A08 - Spatial decoding of hepatic microenvironments to decipher, diagnose and stratify autoim-mune hepatitis (Project Heads Puelles, Ph.D., Victor G. ;  Sebode, Marcial ;  Zimmermann, Marina )
• B01 - Intestinal inflammation modulates liver immune responses (Project Heads Huber, Samuel ;  Kempski, Jan )
• B02 - The role of microbiota-specific T cells as inflammatory drivers of hepatic diseases (Project Heads Bacher, Petra ;  Bang, Corinna )
• B03 - The biliary mucosal interface in hepatic immune regulation (Project Head Schramm, Christoph )
• B04 - Innate lymphoid cell development and modulation of cholangiocytes in biliary atresia (Project Head Bunders, Ph.D., Madeleine )
• B05 - The role of infected hepatocytes in regulating intrahepatic immunity (Project Head Dandri, Maura )
• B06 - The tolerogenic microenvironment in the liver facilitates metastasis formation (Project Head Giannou, Ph.D., Anastasios )
• B07 - X-ray Fluorescence Imaging (XFI) of immune cells and soluble molecules in the liver (Project Heads Bosurgi, Ph.D., Lidia ;  Feliu, Neus ;  Grüner, Florian )
• INF - Central data- and biobank (Project Heads Sebode, Marcial ;  Ückert, Frank )
• SP01 - Discovering liver pathomechanisms via computational and statistical analysis support and train-ing (Project Heads Baumbach, Jan ;  Bonn, Stefan ;  Zolotareva, Ph.D., Olga )
• Z - Central tasks of the collaborative research centre (Project Head Schramm, Christoph )
• iRTGMGK - Academy for translational liver immunology (Project Heads Lohse, Ansgar W. ;  Schwinge, Dorothee )

• Applicant Institution: Universität Hamburg
• Participating Institution: Universitätsklinikum Hamburg-Eppendorf ; Zentrum für Innere Medizin ; I. Medizinische Klinik und Poliklinik; Max-Delbrück-Centrum für Molekulare Medizin (MDC)
• Participating University: Christian-Albrechts-Universität zu Kiel; Technische Universität München (TUM)
• Spokesperson: Professor Dr. Christoph Schramm