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Professor Dr. Jörg Hans Wilhelm Distler

Address Universitätsklinikum Düsseldorf
Klinik für Rheumatologie
Moorenstraße 5
40225 Düsseldorf

Projects

As Applicant
- Current projects
  - GRK5 as a multimodal regulator of TGFβ-dependent fibroblast activation in systemic sclerosis (Research Grants)
  - Characterization of the role of O-GlcNAcylation in osteoclastogenesis (Research Grants)
  - Evaluation of NCOA3 as a Transcriptional Co-regulator of Multiple Profibrotic Networks in Systemic Sclerosis (Research Grants)
  - Loss of epigenetic memory reactivates cell-type specific, proinflammatory transposons in patients with systemic sclerosis (Research Grants)
- Completed projects
  - Die Rolle von Mikropartikeln von Leukozyten für die Angiogenese bei der rheumatoiden Arthritis (Research Grants)
  - Analyse der Effekte von Serotonin auf die Produktion von extrazellulärer Matrix und Evaluation der Serotonin Signalkaskaden als neue anti-fibrotische Therapieansätze in der Systemischen Sklerose (Research Grants)
  - Die Rolle der Notch Signalkaskade bei der Fibroblastenaktivierung in der systemischen Sklerose (Research Grants)
  - Präklinische Evaluation der löslichen Guanylatzyklase als neues Zielmolekül für die Behandlung der systemischen Sklerose (Research Grants)
  - Evaluation of the nuclear receptor Retinoid Acid Receptor related Receptor alpha (RORalpha) as a novel regulator of osteoclastogenesis in rheumatoid arthritis and osteoporosis (Priority Programmes)
  - Evaluation of the TGF-ß induced activation of JAK2 / STAT3 signaling as a key-pathway for fibroblast activation in fibrotic diseases (Research Grants)
  - Wnt5a activates fibroblasts and induces fibrosis via the planar cell polarity pathway (Research Grants)
  - Activation of FGFR3 promotes tissue fibrosis in systemic sclerosis (Research Grants)
  - TGFbeta promotes fibrosis by MYST1-dependent epigenetic regulation of macroautophagy (Research Grants)
  - Targeted inhibition of tyrosine-protein phosphatase SHP2 as a potential approach for the treatment of fibrosis (Research Grants)
  - Nuclear receptors as regulators of tissue responses and potential targets for anti-fibrotic therapies (Heisenberg Professorships)
  - ZAC-1 regulates TGFβ-dependent fibroblast activation in fibrotic diseases by modulation of AP-1 signaling (Research Grants)
As Leader
- Completed projects
  - Imaging-Cytometer (Major Research Instrumentation)
As Project Head
- Current projects
  - Aldehyde dehydrogenase 3A2 (ALDH3A2) as a novel regulator of inflammation and fibrotic tissue remodeling in sclerodermatous chronic graft-versus-host disease (CRC/Transregios)
- Completed projects
  - Liver receptor homolog-1 (LHR-1) regulates inflammation-induced fibrotic tissue remodeling (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Nuclear Receptor 4a1 (Nr4a1) als negativer Rückkopplungsmechanismus bei fibrotischen Erkankungen (Research Grants)
  - Induktion von Hitzeschockprotein 90 durch Transforming Growth Factor ß als neuer pro-fibrotischer Signalweg in der systemischen Sklerose (Research Grants)
As Co-Investigator
- Current projects
  - The role of X-linked inhibitor of apoptosis protein (XIAP) in Systemic Sclerosis and other fibrosing disorders (Research Grants)
  - Engrailed 1 mediates fibroblast activation and tissue fibrosis (Research Grants)
  - TRPA1 as regulator of fibroblast activation in rheumatoid arthritis (Research Grants)

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