Friedrich-Alexander-Universität Erlangen-Nürnberg
Department Chemie und Pharmazie
Professur für Pharmazeutische Chemie
Address
Nikolaus-Fiebiger-Straße 10
91058 Erlangen
Deutschland
GERiT
This institution in GERiT
91058 Erlangen
Projects
Research Grants
Current projects
Exploring the cytomegalovirus-specific nuclear egress complex as a central determinant of viral replication efficiency and host interaction
(Applicants
Eichler, Jutta
;
Marschall, Manfred
)
Structure-based development of bitopic GPCR ligands showing functional selectivity at β-adrenergic receptors
(Applicants
Gmeiner, Peter
;
Sotriffer, Christoph
)
Completed projects
Chemokine receptor CXCR3: Allosteric binding site mapping by photoaffinity labeling and site-directed mutagenesis
(Applicant
Braun, Dieter
)
Covalently-binding GPCR ligands: synthesis and biological investigation
(Applicant
Gmeiner, Peter
)
Development and application of new 18F-glycoconjugates for PET
(Applicant
Maschauer, Simone
)
Development and investigation of isotope-labelled antagonists for the orexin 1 receptor (OX1R) with subtype selectivity over OX2R
(Applicants
Gmeiner, Peter
;
Prante, Olaf
)
Dimer-spezifische GPCR-Liganden: Synthese und biologische Untersuchungen
(Applicant
Gmeiner, Peter
)
Entwicklung Suptyp-selektiver Dopaminrezeptor-Radioliganden für die PET
(Applicants
Gmeiner, Peter
;
Prante, Olaf
)
Molecular mechanisms involved in the modulation of ion channels of the ENaC/Degenerin family by amphiphilic substances
(Applicant
Härteis, Silke
)
Neurotensin-Analoga als atypische Neuroleptika: Synthese, Rezeptorbindungsstudien und SAR-Untersuchungen konformativ fixierter Peptidmimetika
(Applicant
Gmeiner, Peter
)
Structure-guided discovery of high affinity TAS2R14 ligands
(Applicant
Gmeiner, Peter
)
Synthese, Rezeptor-Bindungsstudien und computerunterstützte Struktur-Aktivitätsuntersuchungen neuer Dopaminrezeptor-Antagonisten mit D3- und D4-Subtypselektivität
(Applicant
Gmeiner, Peter
)
Synthetic mimicry of protein binding sites through structure-based design and computational optimization
(Applicant
Eichler, Jutta
)
Reinhart Koselleck Projects
Current projects
Structure-based evolution of potent non-opioid analgesics
(Applicant
Gmeiner, Peter
)
Collaborative Research Centres
Completed projects
Exploration of the structural basis for the functional mimicry of the CD4 binding site of HIV-1gp120: Implications vor virus entry inhibition and the induction of broadly neutralizing antibodies
(Project Head
Eichler, Jutta
)
Functional selectivity as a result of viral chemokine receptor heteromerization
(Project Heads
Stamminger, Thomas
;
Tschammer, Nuska
)
Synthese neuartiger Tetracyclin-Repressor Induktoren
(Project Head
Gmeiner, Peter
)
Major Research Instrumentation
Completed projects
600 MHz NMR-Spektrometerkonsole incl. Kryo-Probenkopf
Research Training Groups
Current projects
GRK 2504: Novel antiviral approaches: from small molecules to immune intervention
(Spokesperson
Überla, Klaus
)
Completed projects
GRK 1071: Viruses of the Immune System
(Spokesperson
Fleckenstein, Bernhard
)
GRK 1910: Medicinal Chemistry of Selective GPCR Ligands
(Spokesperson
Gmeiner, Peter
)
GRK 1962: Dynamic Interactions at Biological Membranes - From Single Molecules to Tissue
(Spokesperson
Böckmann, Rainer
)
