Universitätsklinikum Würzburg
Institut für Klinische Neurobiologie
Address
Versbacher Straße 5
97078 Würzburg
Deutschland
GERiT
This institution in GERiT
97078 Würzburg
Projects
Priority Programmes
Completed projects
Axonal mRNP alterations in spinal muscular atrophy
(Applicants
Briese, Michael
;
Sendtner, Michael A.
)
Differentielle Wirkung neurotropher Faktoren auf Überleben und Axonwachstum: Bedeutung für die Regeneration von axotomierten Motoneuronen
(Applicant
Sendtner, Michael A.
)
Störung des respiratorischen Netzwerks bei LIF-Rezeptordefizienz
(Applicant
Sendtner, Michael A.
)
Störung respiratorischer Interneurone und spinaler Motoneurone bei LIF-Rezeptordefizienz
(Applicant
Ballanyi, Klaus
)
The role of the non-coding RNAs Malat1 and 7SK in motoneuron disease
(Applicants
Briese, Michael
;
Sendtner, Michael A.
)
Research Grants
Current projects
Analysis of affected cellular targets causing cell-autonomous and non-cell-autonomous disease mechanisms in a mouse model for spinal muscular atrophy with respiratory distress type 1 (SMARD1).
(Applicant
Jablonka, Sibylle
)
Axonal 7SK functions in motoneuron development and disease
(Applicant
Briese, Michael
)
Sesquiterpenes und sesquiterpenoid derivatives in food aromas: physiological derivatives and structure-activity relationships in the modulation of GABAA and glycine receptors
(Applicants
Büttner, Andrea
;
Villmann, Carmen
)
Completed projects
Analysis of Brain-derived Neurotrophic Factor Signaling in Spinal Muscular Atrophy
(Applicants
Jablonka, Sibylle
;
Sendtner, Michael A.
)
Autoantibodies and glycinergic dysfunction: Pathophysiology of associated motor disorders
(Applicants
Sommer, Claudia
;
Villmann, Carmen
)
Characterization of periaqueductal grey circuits for top-down motor/autonomic control and bottom-up cardiac interoception in fear and anxiety.
(Applicant
Tovote, Philip
)
Dynamics of local presynaptic protein synthesis of active zone components in spinal motoneurons
(Applicants
Sauer, Markus
;
Sendtner, Michael A.
)
Identification of affected cellular targets, mechanisms and signalling pathways in mouse and cell models for spinal muscular atrophy with respiratory distress type 1 (SMARD1).
(Applicant
Jablonka, Sibylle
)
Neurotransmitter Rezeptor assoziierte Funktionsstörungen: Molekulare Mechanismen und therapeuthische Möglichkeiten
(Applicant
Villmann, Carmen
)
Regulation of synaptic autophagy in motoneurons and its implication in motoneuron disease
(Applicant
Lüningschrör, Patrick
)
Role of differential phosphorylation of c-Jun N-terminal domain in degenerative and regenerative actions of c-jun in the nervous system
(Applicant
Musti, Anna Maria
)
Untersuchung von Krankheitsmechanismen an Motoneuronen eines Mausmodells für spinale Muskelatrophie mit Ateminsuffizienz (SMARD)
(Applicant
Jablonka, Sibylle
)
Heisenberg Professorships
Completed projects
Regulation of fear and anxiety through midbrain circuits for interoception
(Applicant
Tovote, Philip
)
Heisenberg Grants
Completed projects
Regulation of fear and anxiety by midbrain networks for interoception
(Applicant
Tovote, Philip
)
Clinical Research Units
Current projects
Brain stem circuits for pain regulation and resolution
(Applicants
Hein, Grit
;
Tovote, Philip
)
Clinical relevance of axonal NGF signalling for pain resolution after median laparotomy
(Applicants
Briese, Michael
;
Wagner, Nana-Maria
)
KFO 5001: Peripheral mechanisms of pain and their resolution
(Spokesperson
Sommer, Claudia
)
Molecular and cellular functions of Trk receptors in axonal induction and resolution of nociceptor excitability
(Applicants
Briese, Michael
;
Sendtner, Michael A.
)
Neuropathic pain induced by anti-Caspr2 autoantibodies: pathogenesis and resolution
(Applicants
Doppler, Kathrin
;
Villmann, Carmen
)
Neuropathic pain induced by anti Caspr2 autoantibodies: pathogenesis and resolution
(Applicants
Doppler, Kathrin
;
Villmann, Carmen
)
Collaborative Research Centres
Completed projects
Analyse der physiologischen Wirkung neurotropher Faktoren bei der Differenzierung von neuralen Verläuferzellen
(Project Head
Sendtner, Michael A.
)
Die Rolle neurotropher Faktoren bei der Pathogenese von Motoneuronerkrankungen: Untersuchungen an Gen-Knockout Mäusen
(Project Head
Sendtner, Michael A.
)
Konfokale Mikroskopie
(Project Head
Sendtner, Michael A.
)
Pathogenese der spinalen Muskelatrophie (SMA): Charakterisierung der spezifischen Rolle des SMN Proteins in Tiermodellen und Motoneuron-Zellkulturen
(Project Head
Sendtner, Michael A.
)
Proteininteraktion an Rezeptoren für Neurotrophe Faktoren
(Project Head
Sendtner, Michael A.
)
Proteininteraktionen an Rezeptoren für neurotrophe Faktoren
(Project Head
Sendtner, Michael A.
)
SFB 581: Molecular Models for Diseases of the Nervous System
(Spokesperson
Sendtner, Michael A.
)
Untersuchung von Krankheitsmechanismen an Motoneuronen eines Mausmodells für spinale Muskelatrophie mit Ateminsuffizienz (SMARD1)
(Project Head
Jablonka, Sibylle
)
Zentrale Aufgaben des Sonderforschungsbereichs
(Project Head
Sendtner, Michael A.
)
Heisenberg Fellowships
Completed projects
Zoologie
(Applicant
Gerber, Bertram
)
Major Research Instrumentation
Completed projects
Inverses konfokales Mikroskop
Research Units
Current projects
FOR 3004: Synaptic pathology in autoimmune encephalitis – SYNABS
(Spokesperson
Geis, Christian
)
Glycine receptor autoantibodies and spinal disinhibition
(Applicants
Qualmann, Britta
;
Villmann, Carmen
)
Completed projects
Glycine receptor autoantibodies and spinal disinhibition
(Applicants
Sommer, Claudia
;
Villmann, Carmen
)
CRC/Transregios
Current projects
Contribution of brainstem circuit mechanisms to (patho)state dynamics in mouse models of Parkinson’s disease
(Project Head
Tovote, Philip
)
Developing standards, infrastructure and workflows for computational analyses in neuromodulation research
(Project Heads
Muthuraman, Ph.D., Muthuraman
;
Neumann, Wolf-Julian
;
Ritter, Petra
;
Tovote, Philip
)
Influence of anisotropic fiber-reinforcement on cell behavior and printability of bioinks
(Project Heads
Lang, Gregor
;
Schubert, Dirk W.
;
Schäfer, Natascha
)
| Retuning pathway-specific neuronal population dynamics for movement initiation
(Project Heads
Neumann, Wolf-Julian
;
Peng, Yangfan
;
Tovote, Philip
)
Ultraweak hydrogels for molecular and biological functional analyses of cell-matrix and cell-cell 3D networks in neuronal cell culture systems
(Project Heads
Dalton, Paul
;
Strick, Reiner
;
Villmann, Carmen
)
Completed projects
Role of BDNF signaling for striatal plasticity and motor learning
(Project Head
Sendtner, Michael A.
)
Role of hippocampal BDNF signaling in contextual fear learning, fear generalization and context discrimination
(Project Heads
Blum, Robert
;
Sendtner, Michael A.
)
Research Training Groups
Current projects
GRK 2660: Neural mechanisms of (mal)adaptive approach and avoidance behaviour
(Spokesperson
Gamer, Matthias
)
Completed projects
GRK 1048: Molecular Basis of Organ Development in Vertebrates
(Spokesperson
Schartl, Ph.D., Manfred
)
International Research Training Groups
Completed projects
GRK 1156: From synaptic plasticity to behavioural modulation in genetic model organisms
(Spokesperson
Sendtner, Michael A.
)
DFG Research Centres
Completed projects
Forschungsprofessuren
(Project Head
Lohse, Martin J.
)
Kernzentrum
(Project Head
Lohse, Martin J.
)
Nachwuchsgruppeninstitut
(Project Head
Lohse, Martin J.
)
Öffentlichkeitsarbeit
(Project Head
Lohse, Martin J.
)
Studiengänge
(Project Head
Lohse, Martin J.
)
Zentrale Verwaltung
(Project Head
Lohse, Martin J.
)
Graduate Schools
Completed projects
GSC 106: Graduate School for Life Sciences (GSLS)
(Spokesperson
Kisker, Caroline
)
