Go directly to content
Go directly to font size and contrast
Servicenavigation
DFG Homepage
Disclaimer / Copyright
|
Help
|
Data Monitor
Deutsch
Hauptnavigation
Search
Catalogue
People Index
Location Index
About GEPRIS
Project Details
Back
Institution
Charité - Universitätsmedizin Berlin
Campus Charité Mitte
Medizinische Klinik mit Schwerpunkt
Rheumatologie und Klinische Immunologie
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Research Grants
Current projects
Autoreactive B and T lineage cells in renoprotection from immune-mediated damage
(Applicant
Schrezenmeier, Eva
)
Characterizing the impact of the microenvironment on plasma cell function
(Applicant
Hauser, Anja Erika
)
Deconvolution of plasma cell/plasmablast: heterogeneity and origin in systemic lupus
(Applicant
Dörner, Thomas
)
Glucocorticoid-mediated immune-metabolic reprogramming of macrophages
(Applicant
Krönke, Gerhard
)
Mechanisms of protective versus autoreactive B cells in systemic lupus erythematosus
(Applicant
Dörner, Thomas
)
Mechanometabolism in osteoarthritis (OA): Does mechanical stress affect the metabolism of human fibroblast-like synoviocytes and contribute to stromal memory driving OA?
(Applicant
Damerau, Alexandra
)
Novel regulators of plasma cell differentiation
(Applicants
Chu, Van Trung
;
Dörner, Thomas
)
Phenotypic and functional analysis of immune cells during severe COVID-19
(Applicants
Hauser, Anja Erika
;
Niesner, Raluca Aura
;
Radbruch, Helena
)
Purinergic alarmin signaling in acute and chronic viral Infections
(Applicant
Löhning, Max
)
Completed projects
Analyse der Mechanismen nichtgenomischer Glucocorticoidwirkungen
(Applicant
Buttgereit, Frank
)
Analysen des B-Zellgedächtnisses bei Patienten mit SLE
(Applicant
Dörner, Thomas
)
Apoptotic cell-derived membrane microparticles: molecular characterization, immunmodulatory activity and their role in the pathogenesis of systemic lupus erythematosus
(Applicants
Lorenz, Hanns-Martin
;
Schiller, Martin
)
B-Zellsubpopulationen beim Sjögren-Syndrom
(Applicant
Dörner, Thomas
)
Charakterisierung und Modulation von autoantigen-spezifischen T-Zellen beim Systemischen Lupus erythematodes durch das pathogenetisch bedeutsame SmD183-119-Peptid
(Applicant
Riemekasten, Gabriela
)
Delineation of pathogenic plasma cell subsets
(Applicant
Lino, Ph.D., Andreia
)
Differentielle Genexpression in Zellen des Synovialgewebes bei entzündlichen und nichtentzündlichen Gelenkerkrankungen
(Applicant
Häupl, Thomas
)
Differenzierung mesenchymaler Zellen in dreidimensionaler Kultur: In-vitro-Differenzierung und Transplantation vitaler Knorpel- und Knochengewebe
(Applicant
Burmester, Gerd-Rüdiger
)
Dissection of cell-cell communication networks in chronic viral infection by kinetic immune-cell monitoring and mathematical modeling
(Applicants
Löhning, Max
;
Thurley, Kevin
)
Disturbed B cell homeostasis of B cells in SLE: Delineation of intrinsic signaling abnormalities
(Applicant
Dörner, Thomas
)
Entwicklung eines maßgeschneiderten Mikroarrays für die Rheumatoide Arthritis über Vollblutanalytik
(Applicant
Stuhlmüller, Bruno
)
Epigenetische Signaturen von Gedächtnis-T-Zellen und ihre funktionelle Bedeutung
(Applicant
Hamann, Alf
)
Herkunft und Funktion von membranständigen Glucocorticoidrezeptoren humaner Immunzellen
(Applicant
Buttgereit, Frank
)
Identification of gene expression profiles in monocytes/macrophages from patients with rheumatoid arthritis
(Applicant
Stuhlmüller, Bruno
)
Immunologische Charakterisierung der initialen Phase des Frakturhämatoms beim Menschen
(Applicant
Buttgereit, Frank
)
Initiale Phase der Knochenheilung: Inflammation und Organisation
(Applicant
Perka, Carsten
)
JIMI - a network for intravital mikroscopy: dedicated project supervision from cell imaging to cell tracking in living organisms
(Applicant
Niesner, Raluca Aura
)
Molekulare und zelluläre Charakterisierung der Multi-Komponenten-Plasmazell-Nische
(Applicant
Winter, Oliver
)
The interrelationship of autoantibodies in patients with rheumatoid arthritis – rheumatoid factors revisited
(Applicant
Burmester, Gerd-Rüdiger
)
The role of caspase activation in the regulation of osteoclast fusion and bone homeostasis
(Applicant
Scherbel, Carina
)
The role of endogenous glucocorticoids in bone and cartilage destruction by immunologic processes
(Applicant
Buttgereit, Frank
)
The role of the IL-23/Th17 axis as modulator of B cell-mediated (auto)immune responses
(Applicant
Krönke, Gerhard
)
Transcriptional programming and reprogramming of inflammatory T helper 1 cells
(Applicants
Höfer, Thomas
;
Löhning, Max
)
Untersuchung der Dynamik von Antikörper-produzierenden Zellen in Knochenmark und Mucosa mittels Multiphoton Mikroskopie
(Applicant
Hauser, Anja Erika
)
Untersuchung der Rolle der 12/15-Lipoxygenase in der Pathogenese der rheumatoiden Arthritis
(Applicant
Schett, Georg
)
Untersuchung der Rolle von PPAR delta in der Osteoklastogenese und im Knochenstoffwechsel
(Applicant
Krönke, Gerhard
)
Priority Programmes
Current projects
Analyzing the Heterogeneity of Innate Lymphoid Cells and the Relationship with their Microenvironments in situ and in vivo
(Applicant
Hauser, Anja Erika
)
Physical principles of parasite-host interactions in Giardia muris infection
(Applicants
Hauser, Anja Erika
;
Rausch, Sebastian
)
Completed projects
Delineation of human plasma cell subsets and their bone marrow niche
(Applicant
Dörner, Thomas
)
Design principles of NKp46+ ILC-macrophage cross-talk in autoimmune organ damage
(Applicants
Thurley, Kevin
;
Triantafyllopoulou, Antigoni
)
Evaluation of the nuclear receptor Retinoid Acid Receptor related Receptor alpha (RORalpha) as a novel regulator of osteoclastogenesis in rheumatoid arthritis and osteoporosis
(Applicant
Distler, Jörg Hans Wilhelm
)
Investigation of the role of the nuclear receptor NR4a1 during bone turnover and maintenance of the hematopoietic niche in the bone marrow
(Applicant
Krönke, Gerhard
)
Pasteurella multocida toxin as a tool to modulate bone and immune cell differentiation
(Applicant
Hieke-Kubatzky, Katharina
)
The role of CXCR2-ligands for neutrophil mobilization from the bone marrow to peripheral sites
(Applicants
Gunzer, Matthias
;
Waisman, Ari
)
Research Units
Current projects
FOR 2886: PANDORA - Pathways triggering AutoimmuNity and Defining Onset of early Rheumatoid Arthritis
(Spokesperson
Krönke, Gerhard
)
FOR 5560: Crosstalk between B cell metabolism and signaling
(Spokesperson
Jellusova, Julia
)
Spatiotemporal dynamics of calcium signaling and metabolism in germinal center B cells
(Applicants
Hauser, Anja Erika
;
Niesner, Raluca Aura
)
Completed projects
Analysis of osteo-immune crosstalk during bone healing by longitudinal intravital imaging
(Applicants
Hauser, Anja Erika
;
Niesner, Raluca Aura
)
Combined B cell/T cell therapy as novel approach for the re-induction of humoral immune-tolerance.
(Applicant
Krönke, Gerhard
)
Coordination Funds
(Applicant
Krönke, Gerhard
)
FOR 2165: Regeneration in Aged Individuals: Using Bone Healing as a Model System to Characterise Regeneration under Compromised Conditions
(Spokesperson
Duda, Georg
)
T cells as regulative element during the onset of autoantibody-mediated Arthritis
(Applicant
Krönke, Gerhard
)
Translational Arthritis Database, crosslinking clinical and basic Research.
(Applicant
Pachowsky, Milena
)
Collaborative Research Centres
Current projects
Hand Motion Patterns Derived from Empathokinaesthetic Sensor Data as a Diagnostic Parameter for Disease Activity in Patients with Rheumatic Diseases
(Project Heads
Kleyer, Arnd
;
Liphardt, Anna-Maria
;
Schett, Georg
)
Innate immune circuits for bone maintenance and regeneration
(Project Heads
Diefenbach, Andreas
;
Triantafyllopoulou, Antigoni
)
Interactions between myeloid and stromal cells during bone healing under compromising conditions
(Project Heads
Hauser, Anja Erika
;
Niesner, Raluca Aura
)
Completed projects
Analysis of tolerance induction of interleukin-17-producing T helper cells in the small intestine
(Project Heads
Esplugues, Ph.D., Enric
;
Hauser, Anja Erika
)
Biological characterisation of early bone healing and onset of regeneration
(Project Heads
Buttgereit, Frank
;
Perka, Carsten
)
Characterisation of human peripheral and intestinal T cell responses after mucosal antigen exposition: Induction of tolerance vs. immunity
(Project Heads
Dörner, Thomas
;
Ullrich, Reiner
)
Development of tailored protocols for tolerance induction by immunoablation and hematopoietic stem cell transplantation in autoimmune diseases
(Project Heads
Alexander, Tobias
;
Arnold, Renate
;
Hiepe, Falk
)
Differenzierung autoreaktiver B-Lymphozyten beim systemischen Lupus erythematodes
(Project Head
Dörner, Thomas
)
Generation und Homeostase von autoreaktiven Plasmazellen bei Autoimmunerkrankungen
(Project Heads
Hiepe, Falk
;
Manz, Rudolf
)
Generation und Homeostase von autoreaktiven Plasmazellen bei Autoimmunerkrankungen
(Project Heads
Hiepe, Falk
;
Manz, Rudolf
)
Glucocorticoid-mediated immune-metabolic reprogramming of macrophages during the resolution of inflammation
(Project Head
Krönke, Gerhard
)
Impaired phagocyte function in the immunopathogenesis of systemic lupus erythematosus (SLE): Etiology and therapeutic intervention
(Project Heads
Triantafyllopoulou, Antigoni
;
Voll, Reinhard
)
Integration of signal transduction and cytokine expression in T helper lymphocytes
(Project Heads
Höfer, Thomas
;
Löhning, Max
;
Radbruch, Andreas
)
Interaktionen des Immunsystems mit mesenchymalen Zellen bei der chronischen Polyarthritis: Chondrozytenmembranen als Autoantigene
(Project Head
Burmester, Gerd-Rüdiger
)
Modulation von chronischen Immunreaktionen über CD152 (CTLA-4)
(Project Heads
Brunner-Weinzierl, Monika Christine
;
Burmester, Gerd-Rüdiger
)
N01: Understanding and exploiting mechanisms controlling T cell tolerance, protective immune responses and autoimmunity
(Project Head
Geginat, Ph.D., Jens
)
New generation anti-B cell therapy
(Project Heads
Dörner, Thomas
;
Salama, Abdulgabar
)
Organisation der T-Zell-Hilfe bei der Erzeugung von Rheumafaktoren bei der Rheumatoiden Arthritis
(Project Heads
Bläß, Stefan
;
Burmester, Gerd-Rüdiger
)
Störungen des humoralen Gedächtnisses bei Patienten mit Sjögren-Syndrom
(Project Heads
Dörner, Thomas
;
Hansen, Arne
)
Suppression of autoreactive T cell responses by Th2 cells
(Project Head
Löhning, Max
)
Suppression of unwanted immune reactions
(Project Heads
Babel, Nina
;
Löhning, Max
;
Riemekasten, Gabriela
)
Targeting of memory plasma cells in autoimmune diseases
(Project Heads
Burmester, Gerd-Rüdiger
;
Hiepe, Falk
;
Radbruch, Andreas
)
Research Fellowships
Completed projects
Visualization of Germinal Center Dynamics and Differentiation of Antibody-Forming Cells in vivo by Multiphoton Microscopy
(Applicant
Hauser, Anja Erika
)
CRC/Transregios
Current projects
Differentiation and fate of osteoclasts during health and disease
(Project Heads
Grüneboom, Anika
;
Krönke, Gerhard
)
ILC3-myeloid cell crosstalk during homeostatic maintenance of the epithelial barrier and during IBD
(Project Heads
Diefenbach, Andreas
;
Triantafyllopoulou, Antigoni
)
Organ defense during metastatic colonization by shielding macrophages
(Project Heads
Krönke, Gerhard
;
Pukrop, Tobias
)
Regulation of CNS Lupus by brain macrophages
(Project Head
Triantafyllopoulou, Antigoni
)
Completed projects
Analysing B lymphocytes in their environment by complementing longitudinal and functional intravital microscopy with multiplexed immunofluorescence histology
(Project Heads
Hauser, Anja Erika
;
Niesner, Raluca Aura
)
Analysis of B cell dynamics in chronic neuroinflammation
(Project Heads
Hauser, Anja Erika
;
Radbruch, Helena
)
Heterogeneity and Imprinting of Long-lived Plasma Cells
(Project Heads
Dörner, Thomas
;
Mei, Henrik
)
Mononuclear phagocyte differentiation trajectories driving a cytokine storm and tissue damage in COVID-19
(Project Heads
Herold, Ph.D., Susanne Valerie
;
Triantafyllopoulou, Antigoni
)
Selective plasma cell targeting
(Project Heads
Alexander, Tobias
;
Hiepe, Falk
;
Hoyer, Bimba Franziska
)
Clinical Research Units
Current projects
Characterization of checkpoint receptor-mediated B-T-cell communication as novel targets for immunotherapies
(Applicants
Dörner, Thomas
;
Sawitzki, Birgit
;
Scheibe, Franziska
)
KFO 5023: BECAUSE-Y Berlin Center for Diagnosing, Understanding and Treating Antibody(Y)-mediated Neurological Diseases
(Spokesperson
Endres, Matthias
)
Research Training Groups
Current projects
GRK 2599: FAIR - Fine-Tuners of the Adaptive Immune Response
(Spokesperson
Zaiss, Mario M.
)
Completed projects
GRK 1121: Genetic and Immunologic Determinants of Pathogen-Host-Interactions
(Spokesperson
Lucius, Richard
)
GRK 1660: Key Signals of Adaptive Immune Response
(Spokesperson
Jäck, Hans-Martin
)
Additional Information
© 2024
DFG
Disclaimer / Copyright
/
Privacy Policy
Textvergrößerung und Kontrastanpassung
