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Institution
Universitätsklinikum Münster
Institut für Physiologische Chemie und Pathobiochemie
Address
Waldeyerstraße 15
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Research Fellowships
Completed projects
Differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase (NDST) isozymes 1-4 in the development of the mouse
(Applicant
Grobe, Kay
)
Research Grants
Current projects
Engineered Bacterial Coacervates
(Applicant
Di Iorio, Ph.D., Daniele
)
Light Controlled Designer Biofilms and Bacteriabots using Photoswitchable Bacterial Adhesions
(Applicant
Wegner, Seraphine
)
Regulation of macrophage dynamics and adipose stromal cells by laminins during adipose tissue remodelling in obesity
(Applicant
Sorokin, Lydia
)
Role and redox-regulation of integrins α2β1 on osteoclasts in differentiation and osteolysis
(Applicant
Eble, Johannes Andreas
)
The role of direct heparan sulfate interactions and Ca2+ complexation in Hedgehog gradient formation in vivo
(Applicants
Grobe, Kay
;
Steffes, Georg
)
The role of extracellular ERp57/PDIA3 in healthy and osteoarthritic articular cartilage
(Applicant
Dreier, Rita
)
Completed projects
Effect of bifunctional venom-derived antagonists of platelet adhesion receptors (a2b1 integrin and GPIb) on platelet-supported hematogenous metastasis
(Applicant
Eble, Johannes Andreas
)
Functional Significance of the Basement Membrane in Leukocyte Extravasation in a Mouse Experimental Autoimmune Encephalomyelitis (EAE)
(Applicant
Sorokin, Lydia
)
Function of ERp57 in the development and progression of osteoarthritis in the knee joint
(Applicant
Dreier, Rita
)
HsP90 cochaperones Aha1 and Tpr2/Dnajc7 in Endoplasmic Reticulum associated protein quality control
(Applicant
Obermann, Wolfgang M.J.
)
In vivo function of differentially processed Hedgehog morphogens
(Applicant
Grobe, Kay
)
Lysosomes in Drosophila melanogaster: Characterization of key components and analysis of their impact for neuronal development.
(Applicant
Pohlmann, Regina
)
Mechanisms of Integrin α2β1 driven cell-matrix interaction in the course of bone regeneration and fracture healing
(Applicant
Stange, Richard
)
Parakrine Regulation der enchondralen Ossifikation
(Applicant
Bruckner, Peter
)
Physiologische Rolle von kollagenbindenden Integrinen auf Endothelzellen während der Angiogenese
(Applicant
Eble, Johannes Andreas
)
Processed Sonic hedgehog - an active signaling protease?
(Applicants
Grobe, Kay
;
Schilling, Oliver
)
Regulation der Hyaluronan-Synthese
(Applicant
Prehm, Peter
)
Role of the gelatinases, MMP-2 and MMP-9, in cellular transmigration of basement membranes. The project deals with strategic cleavage of novel substrates by the gelatinases that are required for generation of a chemotactic gradient in inflamed tissues.
(Applicant
Sorokin, Lydia
)
Suprastructural specificity of integrin-mediated cell-matrix-interactions: Relation to cartilage homeostasis and osteoarthritis
(Applicants
Bruckner, Peter
;
Eble, Johannes Andreas
)
Syndecan-4 as a regulator of chondroblast development during fracture healing
(Applicant
Stange, Richard
)
The contribution of endothelial basement membrane laminins and immune cells to functional integrity of the neurovascular unit
(Applicant
Sorokin, Lydia
)
Untersuchung der rheumatischen Knorpelzerstörung mit Hilfe eines neu etablierten in vitro Modells (MATRIN-Assay) unter Verwendung von authentischen Kollagenmatrizes
(Applicant
Hansen, Uwe
)
Untersuchungen zum Transport der lysosomalen beta-Glucocerebrosidase
(Applicant
Pohlmann, Regina
)
Untersuchung von Giften südamerikanischer Schlangen und anderer Gifttiere auf Inhibitoren von kollagen- und lamininbindenden Integrinen
(Applicant
Eble, Johannes Andreas
)
Priority Programmes
Current projects
Adaptive Engineered Bacterial Coacervates
(Applicants
Di Iorio, Ph.D., Daniele
;
Philipp, Bodo
)
Completed projects
Functional characterization of Laminin 10
(Applicant
Sorokin, Lydia
)
Identification of alpha 1 beta 1 and alpha 2 beta 2 integrin recognition motifs within basement membrane ligands using phage display library screening, and their physiological effects on cells
(Applicant
Eble, Johannes Andreas
)
Thiol-based switches in integrins: molecular analysis and redox-regulatory implications in cell-matrix interaction and migration.
(Applicant
Eble, Johannes Andreas
)
Heisenberg Professorships
Completed projects
The role of the extracellular matrix constituent heparan sulfate in Hedgehog morphogen function
(Applicant
Grobe, Kay
)
Heisenberg Grants
Completed projects
Biological roles of heparan sulfate in Hedgehog-dependent signaling and morphogenetic gradient formation
(Applicant
Grobe, Kay
)
Collaborative Research Centres
Current projects
Dynamic and spatiotemporal control of Notch signaling for assembling precise multicellular structures
(Project Head
Wegner, Seraphine
)
Dynamic imaging and molecular mechanisms of myeloid cell infiltration into the inflamed peritoneum
(Project Head
Sorokin, Lydia
)
Molecular parameters for the dynamic assembly of Hedgehog signaling platforms
(Project Head
Grobe, Kay
)
Multistimuli sensing with memory and feedback function using photoswitchable proteins and coordination chemistry
(Project Head
Wegner, Seraphine
)
Completed projects
Adhesive Interactions between Staphylococcus aureus and Matrix-Suprastructures as Determinants of Invasive Infections: the Role of Eap and Emp
(Project Heads
Bruckner, Peter
;
Löffler, Bettina
;
Peters, Georg
)
Bedeutung von Decorin und Fibromodulin für die entzündungsbedingte Angiogenese
(Project Head
Schönherr, Elke
)
Central Administration
(Project Head
Bruckner, Peter
)
Die Regulation der bildung von Fenestrierungen, Poren und Caveolae im Blutgefäßendothel der Niere: MECA-32 und FELS als Mitglieder einer neuen Proteinfamilie von Caveolae-assoziierten Molekülen
(Project Head
Hallmann, Rupert
)
Die Rolle des Gefäßwandendothels bei der Entwicklung von Entzündungsreaktionen
(Project Head
Hallmann, Rupert
)
Entzündliche Gelenkserkrankungen: Parakrine Wechselwirkungen von Entzündungszellen mit Chondrozyten in vitro
(Project Head
Bruckner, Peter
)
Environmental Control of Chondrocyte Differentiation in Endochondral Ossification and Degenerative Joint Diseases
(Project Head
Dreier, Rita
)
Inhibition of Hyaluronan Export
(Project Head
Prehm, Peter
)
Interplay of cell adhesion and matrix proteolysis in barrier-braking invadopodia of tumor cells
(Project Head
Eble, Johannes Andreas
)
Mechanisms of leukocyte penetration of vascular cell basement membranes
(Project Head
Sorokin, Lydia
)
Mechanisms of Leukocyte Transmigration of Endothelial Cell Basement Membranes
(Project Head
Sorokin, Lydia
)
Nachwuchsgruppe des SFB 284
(Project Head
Obermann, Wolfgang M.J.
)
Redox-regulation of integrin-matrix contacts during cell adhesion and migration
(Project Head
Eble, Johannes Andreas
)
Roles of Heparan Sulfate in Sonic Hedgehog (Shh) Gradient Formation and Cardiac Development in the Mouse
(Project Head
Grobe, Kay
)
SFB 492: Extracellular Matrix: Biogenesis, Assembly and Cellular Interactions
(Spokesperson
Bruckner, Peter
)
Structural and Functional Characterisation of the Extracellular Matrix of the Spleen
(Project Head
Sorokin, Lydia
)
Structured training programs 'Master Experimental Medicine' and 'MedK'
(Project Heads
Hallmann, Rupert
;
Karch, Helge
)
Struktur, Stoffwechsel und Interaktionen von Dermatansulfat-Proteoglykanen der extrazellulären Matrix
(Project Head
Kresse, Hans
)
Suprastructure of the Extracellular Matrix: Macromolecular Alloys and Networks
(Project Head
Bruckner, Peter
)
Zelluläre Wechselwirkungen mit Laminin-5: Von der Integrinerkennung zur zellbiologischen Funktion
(Project Head
Eble, Johannes Andreas
)
CRC/Transregios
Completed projects
Molecular mechanisms and sites of action of the gelatinases in autoimmune CNS inflammation: do MMP-2/-9 contribute to meningeal inflammation and secondary cortical damage?
(Project Heads
Meyer zu Hörste, Gerd
;
Schäfers, Michael
;
Sorokin, Lydia
)
Physiological roles of collagen-binding integrins on endothelial cells in angiogenic sprouting and vessel integrity
(Project Head
Eble, Johannes Andreas
)
Clinical Research Units
Current projects
KFO 342: Organ Dysfuncion During Systemic Inflammation
(Spokesperson
Zarbock, Alexander
)
Role of Neuropilin-1 on Lung Macrophages during Pulmonary Inflammation
(Applicants
Eble, Johannes Andreas
;
Zarbock, Alexander
)
Research Training Groups
Completed projects
GRK 750: Vascular Injury in Heart and Kidney: Pathogenesis and Diagnostics
(Spokesperson
Goppelt-Strübe, Margarete
)
International Research Training Groups
Completed projects
GRK 1549: Molecular and Cellular Glyco-Sciences (MCGS). Understanding Structure/Function Relationships of Carbohydrate/Protein Interactions
(Spokesperson
Moerschbacher, Bruno
)
Clusters of Excellence
Completed projects
EXC 1003: Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms
(Spokesperson
Sorokin, Lydia
)
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