Georg-August-Universität Göttingen
Institut für Organische und Biomolekulare Chemie
Address
Tammannstraße 2
37077 Göttingen
Deutschland
GERiT
This institution in GERiT
37077 Göttingen
Projects
Research Grants
Current projects
Bone adhesives based on photochemically cross linked collagen-mimetic peptides
(Applicants
Schilling, Arndt Friedrich
;
Simeth-Crespi, Nadja Anita
)
Development of efficient domino and C–H functionalization reactions toward fluorine-containing N-heterocycles for Life Science
(Applicants
Ackermann, Lutz
;
Tsogoeva, Svetlana
)
Enantioselective Synthesis and Functionalization of Heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane and Related Cage Compounds
(Applicant
Alcarazo, Manuel
)
Ion energization and thermalization in electrospray-ionization mass spectrometry
(Applicant
Koszinowski, Konrad
)
Lesional and intralesional treatment of cutaneous squamous cell carcinoma and melanoma with prodrugs of duocarmycin-derivatives in the mouse
(Applicants
Heppt, Markus
;
Tietze, Julia
)
Mechanism of iron-catalyzed cross-coupling reactions
(Applicant
Koszinowski, Konrad
)
Reconstitution of Mineral Morphogenesis in Membrane-enclosed Compartments
(Applicants
Diez, Stefan
;
Steinem, Claudia
)
Redox control of ER-mitochondria communication: Implications for melanoma pathobiology
(Applicants
Bogeski, Ivan
;
Simeth-Crespi, Nadja Anita
)
Structure and mechanics of strained membrane-bound F-actin/intermediate filament layers
(Applicants
Köster, Sarah
;
Steinem, Claudia
)
Thermodynamics versus kinetics in protodemetalation/deprotometalation reactions
(Applicant
Koszinowski, Konrad
)
Unraveling the Membrane-Selective Mechanism of Lugdunin: Insights into Specificity for Gram-Positive Bacteria and Antimicrobial Activity
(Applicants
Böckmann, Rainer
;
Steinem, Claudia
)
Completed projects
Aggregation and Reactivity of Organocuprates
(Applicant
Koszinowski, Konrad
)
Alanyl-Peptidnucleinsäure/DNA-Chimäre zum Nachweis von DNA
(Applicant
Diederichsen, Ulf
)
Biofunktionalisierung poröser Oberflächen: Membranüberspannte Nano/Mikrokompartimente zum Studium zellulärer Prozesse
(Applicant
Steinem, Claudia
)
Chiral cationic phosphonites: Applications towards the enantioselective synthesis of helicenes and related polyarenes
(Applicant
Alcarazo, Manuel
)
Design and synthesis of new electrophilic reagents based on sulfur
(Applicant
Alcarazo, Manuel
)
Design and synthesis of very strong pi-acceptor ancillary ligands. Applications in Au(I) and Pt(II) catalysis and the synthesis of natural products
(Applicant
Alcarazo, Manuel
)
DNA-Bindungsstudien neuartiger Analoga des Chinoxalin-Antibiotikums Triostin A
(Applicants
Diederichsen, Ulf
;
Sheldrick, George M.
)
DNA-Sekundärstruktur als Code für biologische Information
(Applicant
Diederichsen, Ulf
)
Electrospray ionization from aprotic solvents
(Applicant
Koszinowski, Konrad
)
Enantioselektive Palladium-katalysierte Domino-Reaktionen zur Synthese von Chromanen. Totalsynthese von Diversonol, Siccanin, Siccanochromenen, Daurichromensäure, Rhododaurichromansäure A und Secalonsäuren
(Applicant
Tietze, Lutz F.
)
Entwicklung neuartiger Zytostatika für eine selektive Krebstherapie
(Applicant
Tietze, Lutz F.
)
Entwicklung von Pd-katalysierten Domino-Reaktionen zur Synthese von molekularen Schaltern und Naturstoffen vom Lignan-Typ des Linoxepins
(Applicant
Tietze, Lutz F.
)
Explorative Investigation of Endemic Jordanian Cyanobacteria with Respect to Medical and Ecological Implications
(Applicant
Laatsch, Hartmut
)
Funktionalisierung von Cystinknoten-Mikroproteinen durch Kombination chemischer und rekombinanter Synthesestrategien
(Applicants
Diederichsen, Ulf
;
Kolmar, Harald
)
Kartierung der elastischen Eigenschaften von freitragenden artifiziellen und biologischen Membranen auf porösen Substraten
(Applicants
Janshoff, Andreas
;
Steinem, Claudia
)
Kinetik der Komplexbildung und Katalyse mit Phosphanoxiden und Phosphanchloriden
(Applicant
Ackermann, Lutz
)
Low-Valent Cobalt-Catalyzed C-H Activation: Mechanistic Insight for Synthetic Applications
(Applicants
Ackermann, Lutz
;
Koszinowski, Konrad
)
Membranbiosensoren: Ligand-induzierte Ausbildung von peptidischen Helix-Bündeln in Lipidmembranen
(Applicant
Steinem, Claudia
)
Molekulares Targeting in der Neutroneneinfang-Therapie von malignen Tumoren
(Applicant
Tietze, Lutz F.
)
Noble applications of abundant metals: Asymmetric Co, Ni, Fe and Mn-catalyzed C-H activation
(Applicant
Ackermann, Lutz
)
Quantitative Analyse der Ezrin-Aktin Wechselwirkung an Membranen
(Applicants
Gerke, Volker
;
Steinem, Claudia
)
Reductive eliminations – trends across the d block
(Applicant
Koszinowski, Konrad
)
Self-organization and mechanics of actomyosin networks attached to artificial and cellular plasma membranes
(Applicants
Janshoff, Andreas
;
Steinem, Claudia
)
Synthese von Secalonsäuren und Analoga sowie von Diversonol und Siccanin über enantioselektive Wacker-Oxidationen
(Applicant
Tietze, Lutz F.
)
Totalsynthese von Spinosyn-Analoga
(Applicant
Tietze, Lutz F.
)
Untersuchung der Aktivität von Transmembranproteinen in porenüberspannenden Lipidmembranen
(Applicant
Steinem, Claudia
)
Research Fellowships
Completed projects
Chemie und Biologie des E-Signals in verschiedenen Myxobakterien und seine Funktion in Lebenszyklus, Differenzierung und Sekundärmetabolismus
(Applicant
Bode, Helge Björn
)
Chemische und genetische Untersuchungen zur Biosynthese von Marinon sowie Darstellung von prenylierten Aromaten durch kombinatorische Biosynthese
(Applicant
Krastel, Philipp
)
Construction of two-dimensional polymers by an interfacial metal-organic complexation approach
(Applicant
Hungerland, Tim
)
Design und Synthese neuartiger Piperidin-Inhibitoren von Aspartatpeptidasen
(Applicant
Wöhrmann, Michael
)
N-Arylation and N-Alkylation of Amides via the Merger of Base Metal Catalysis and Photocatalysis
(Applicant
Mohr, Jens
)
Synthese des marinen Naturstoffs Pelorusid A und seiner Analoga als neue Mikrotubuli-stabilisierende Cytostatika
(Applicant
Lorenz, Katrin
)
The Cooperative Asymmetric Copper Catalysis and Visible-Light Photocatalysis for Sustainable Enantioselective Synthesis
(Applicant
Pagire, Ph.D., Santosh
)
Emmy Noether Independent Junior Research Groups
Completed projects
Neuartige, einfach zugängliche Liganden und Katalysatorsysteme: Hypophosphorigsäurederivate / N-heterocyclische Carbene
(Applicant
Ackermann, Lutz
)
Priority Programmes
Current projects
Machine Learning for developing and understanding novel, asymmetric 3d metal-catalyzed C–H activations
(Applicant
Ackermann, Lutz
)
Completed projects
Control of London Dispersion Interactions in Metal-Catalyzed C-H Activation
(Applicant
Ackermann, Lutz
)
Dispersion Interaction in Metal- and Organocatalysis - Assessment and Implementation in Salalen Ligands and N-Heterocyclic Carbenes
(Applicant
Berkessel, Albrecht
)
Enantioselective domino reactions with chiral organocatalysts
(Applicant
Tietze, Lutz F.
)
Selective multifunctionalization of antibody fragments and antibodies by enzyme-mediated orthogonal ligations
(Applicants
Diederichsen, Ulf
;
Kolmar, Harald
)
Research Units
Completed projects
FOR 2038: Nanopatterned Organic Matrices in Biological Silica Mineralisation
(Spokesperson
Kröger, Nils
)
Silica Nano- to Micro-Patterning at the Membrane Interface in vitro
(Applicant
Steinem, Claudia
)
Collaborative Research Centres
Current projects
Collective dynamics of ion channels: statistical modeling and analysis
(Project Heads
Li, Housen
;
Steinem, Claudia
)
In vitro reconstitution of inhibitory GABAergic postsynapses
(Project Head
Steinem, Claudia
)
Completed projects
Biologische Signalamplifikation durch synthetische orientierte Helix-Bündel mit Rezeptorfunktionen in Lipidmembranen
(Project Head
Steinem, Claudia
)
Biosynthese, Derivatisierung und Synthese des cytostatisch und cytotoxisch wirksamen Mensacarcins. Ableitung von Struktur-Wirkungsbeziehungen
(Project Heads
Tietze, Lutz F.
;
Zeeck, Axel
)
Biosynthese und Vorläufer-induzierte Biotransformation des Peptidlactons Hormaomycin
(Project Head
Zeeck, Axel
)
Central administration and project coordination of the CRC
(Project Head
Steinem, Claudia
)
Chemische und Biologische Synthese von Pyripyropenen und Strukturanaloga
(Project Heads
Beifuss, Uwe
;
Zeeck, Axel
)
Construction of novel hybrid biooligomers as artificial SNAREs to dissect the mechanism of SNAREs in membrane docking and fusion
(Project Heads
Diederichsen, Ulf
;
Jahn, Reinhard
)
Cyclopropan-Analoga mehrfach ungesättigter Fettsäuren und ihe biologische Wirkung
(Project Head
de Meijere, Armin
)
Design, Synthese und Funktion Membran-ständiger Haptene für eine Tumor-Immuntherapie
(Project Heads
Götze, Otto
;
Tietze, Lutz F.
)
Design und Synthese neuartiger Prodrugs der cytotoxischen Antibiotika CC-1065 und Duocarmycin für eine selektive Krebstherapie
(Project Heads
Alves, Frauke
;
Schuberth, Ingrid
;
Tietze, Lutz F.
)
DNA-Bindungsstudien neuartiger Analoga des Chinoxalin-Antibiotikums Triostin A
(Project Heads
Diederichsen, Ulf
;
Sheldrick, George M.
)
Effiziente Synthese von biologisch aktiven Naturstoffen durch Palladium-katalysierte Reaktionssequenzen
(Project Heads
Schuberth, Ingrid
;
Tietze, Lutz F.
)
Entwicklung chemisch induzierbarer Promotoren
(Project Heads
Ficner, Ralf
;
Gatz, Christiane
;
Sheldrick, George M.
;
Tietze, Lutz F.
)
Entwicklung und funktionelle Prüfung neuer Liganden für den Maxi-K+-Kanal
(Project Heads
Terlau, Heinrich
;
Tietze, Lutz F.
)
Identifizierung und Charakterisierung anionischer metallorganischer Intermediate
(Project Head
Koszinowski, Konrad
)
Katalytische monoklonale Antikörper zur enantioselektiven Synthese von Vitamin E
(Project Heads
Peters, J. Hinrich
;
Sheldrick, George M.
;
Tietze, Lutz F.
)
Kinetik und Verzweigungsverhältnisse unimolekularer Reaktionen hochgespannter Kohlenwasserstoffe
(Project Heads
Grubmüller, Helmut
;
de Meijere, Armin
)
Membrane fusion assayed by pore-spanning lipid bilayers
(Project Head
Steinem, Claudia
)
Modulation von Struktur und Funktion des Cystinknoten-Mikroproteins EETI-II durch Inkorporation nicht-natürlicher Aminosäuren und den Einsatz molekularer Repertoire-Techniken
(Project Heads
Diederichsen, Ulf
;
Kolmar, Harald
)
Natürliche und nicht-natürliche Alpha- und Beta-Aminosäuren mit Cyclopropylgruppen und deren biologische Wirkung beim Einbau in Peptide und Peptidmimetika
(Project Heads
de Meijere, Armin
;
Zeeck, Axel
)
Präorganisierte Metall-PNA-Konjugate als modulare, funktionelle Modellsysteme für zinkhaltige Metalloenzyme
(Project Heads
Diederichsen, Ulf
;
Meyer, Franc
)
Self-organization and mechanics of actomyosin networks attached to artificial and cellular plasma membranes
(Project Heads
Janshoff, Andreas
;
Steinem, Claudia
)
SFB 416: Chemische und biologische Synthese und Transformation von Naturstoffen und Naturstoff-Analoga
(Spokesperson
Tietze, Lutz F.
)
SFB 803: Functionality Controlled by Organisation in and between Membranes
(Spokesperson
Steinem, Claudia
)
Strukturaufklärung und Modifikation der Viscotoxine aus Viscum album L.
(Project Heads
Sheldrick, George M.
;
Zeeck, Axel
)
Tailor-made glycosphingolipids as a toolkit to visualize domain formation and lipid-protein interactions
(Project Heads
Steinem, Claudia
;
Werz, Daniel B.
)
The contribution of non-covalent interactions for incorporation, organization, and dynamics of peptide helices in lipid membranes
(Project Heads
Diederichsen, Ulf
;
Steinem, Claudia
)
Zentrale Verwaltung des SFB
(Project Head
Tietze, Lutz F.
)
CRC/Transregios
Completed projects
Membrane microdomain formation in artificial membrane systems
(Project Head
Steinem, Claudia
)
Emmy Noether International Fellowships
Completed projects
Zustandsaufgelöste Reaktionsdynamik
(Applicant
Koszinowski, Konrad
)
Major Research Instrumentation
Completed projects
2D-UHPLC
400 MHz NMR-Spektrometer
400 MHz NMR-Spektrometer mit LN2-Cryoprobenkopf
Coating unit for thin layers
Einkristallröntgendiffraktometer
ESI-TOF-Massenspektrometer mit HPLC und DESI-Quelle
Flow nuclear magnetic resonance spectrometer
GC/TOF-Massenspektrometer
High Pressure Liquid Chromatography-Electrospray Ionization-Mass Spectrometry (HPLC-ESI-HRMS)
High-resolution electrospray-ionization tandem-mass spectrometer
High resolution mass spectrometer equipped with electron ionisation (EI), chemical ionisation (CI), direct sample inlet and gas chromatograph
High Throughput Electrochemical Workstation System for Organic Electrocatalysis and In-Operando Reaction Control
Ionenmobilitäts-Massenspektrometer
Katalyse-Monitoring-Einheit
Konfokales Laserraster-Mikroskop
Konfokales Laserscanning-Mikroskop
MALDI-TOF-Massenspektrometer
Quadrupole ion trap mass spectrometer with electrospray-ionization source and cryo option
Rasterelektronenmikroskop
Single crystal X-ray diffractometer with Mo and Ag sources
UHPLC-MS/MS
Research Training Groups
Current projects
GRK 2455: BENCh - Benchmark Experiments for Numerical Quantum Chemistry
(Spokesperson
Mata, Ricardo
)
GRK 2756: Cytoskeletal elements of active matter – from molecular interactions to cellular biophysics (CYTAC)
(Spokesperson
Köster, Sarah
)
Completed projects
GRK 640: Natural Sensory Photoreceptors, Artificial Photoreceptors, Principle of Light Reception and Conversion into a Modulated Signal
(Spokesperson
Dick, Bernhard
)
International Research Training Groups
Completed projects
GRK 1422: Metal Sites in Biomolecules: Structures, Regulation and Mechanisms
(Spokesperson
Diederichsen, Ulf
)
Major Instrumentation Initiatives
Completed projects
Göttingen MINFLUX
Clusters of Excellence
Completed projects
EXC 171: Microscopy at the Nanometer Range (within DFG Research Centre CMPB)
(Spokespersons
Rizzoli, Ph.D., Silvio-Olivier
;
Schild, Detlev
)
Graduate Schools
Completed projects
GSC 226: Göttingen Graduate School for Neurosciences and Molecular Biosciences (GGNB)
(Spokesperson
Ficner, Ralf
)
Clusters of Excellence (ExStra)
Current projects
EXC 2067: Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells (MBExC)
(Spokespersons
Cramer, Patrick
;
Moser, Tobias
;
Steinem, Claudia
)
