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Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt

Address Ingolstädter Landstraße 1
85764 Neuherberg
Deutschland

GERiT This institution in GERiT

85764 Neuherberg

Projects

Infrastructure Priority Programmes
- Completed projects
  - From single processes to cycles: Evolution of nitrogen turnover in terrestrial ecosystems of the maritime Antarctic
    (Applicant Gschwendtner, Silvia )
  - Klimavariationen in der Antarktis seit dem letzten Glazialen Maximum, abgeleitet aus den Verhältnissen stabiler Isotope (2-H, 18-o) im EPICA-Eisbohrkern aus Dronning Maud Land
    (Applicant Stichler, Willibald )
Independent Junior Research Groups
- Completed projects
  - Next generation in vivo optical imaging with novel short-wave infrared emitting probes
    (Applicant Bruns, Oliver )
Collaborative Research Centres
- Current projects
  - Mechanisms of immune activation vs. tolerance in autoimmune Type 1 diabetes
    (Project Head Daniel, Carolin )
  - Mechanisms of Nfe2l1-linked inflammation and atherogenesis
    (Project Heads Bartelt, Alexander ; Bruns, Oliver )
  - Neuroendocrine control of atherogenesis
    (Project Heads Hofmann, Susanna ; Müller, Timo ; Tschöp, Matthias )
  - SFB 1054: Control and Plasticity of Cell-Fate Decisions in the Immune System
    (Spokesperson Brocker, Thomas )
  - SFB 1064: Chromatin Dynamics
    (Spokesperson Becker, Peter Burkhard )
  - SFB 1123: Atherosclerosis: Mechanisms and Networks of Novel Therapeutic Targets
    (Spokesperson Weber, Christian )
  - SFB 1309: Chemical Biology of Epigenetic Modifications
    (Spokesperson Carell, Thomas )
- Completed projects
  - Adoptive Immuntherapie rezidivierender Zytomegalievirus-erkrankungen nach allogener Knochenmarktransplantation
    (Project Heads Hahn, Gabriele Ruth ; Kolb, Hans-Jochem ; Mischak-Weissinger, Eva )
  - An RNA-centered view on the journey of ASH1 mRNA from transcription to localization
    (Project Head Niessing, Dierk )
  - Bioinformatic analysis of genomes and transcriptomes
    (Project Head Mayer, Klaus F.X. )
  - Centralized SOP/GMP Development of Phase I/II Clinical Studies
    (Project Head Schendel, Ph.D., Dolores J. )
  - Comparative transcription and proteom expression profiling in herbaceous and woody plants upon abiotic/biotic stress
    (Project Heads Ernst, Dieter ; Müller-Starck, Gerhard )
  - Computational models of neoplasmic heterogeneities and lineage choice
    (Project Heads Fuchs, Christiane ; Theis, Fabian )
  - Control of T cell tolerance and regulation through NFAT complex formation
    (Project Head Heissmeyer, Vigo )
  - Core facility monoclonal antibodies for SFB 596
    (Project Head Kremmer, Elisabeth )
  - Development and function of midbrain GABAergic neurons
    (Project Heads Guimera Vilaro, Jordi ; Wurst, Wolfgang )
  - Dynamic chromatin in replication origin determination
    (Project Head Schepers, Aloys )
  - Effects of abiotic and biotic stress on rhizodeposition an enzyme activities in the mycorrhizosphere of herbaceous and woody plants
    (Project Heads Munch, Jean Charles ; Schloter, Michael )
  - Effects of obesity and anti-obesity treatments on pancreatic cancer
    (Project Heads Stemmer, Kerstin ; Tschöp, Matthias )
  - Epstein-Barr Virus, c-myc Aktivierung und T-Zellfunktion in der Pathogenese von B-Zellymphomen bei HIV-Infizierten
    (Project Head Polack, Axel )
  - Etablierung einer humanisierten, doppelt-transgenen Mauslinie als Krankheitsmodell für den Typ-I-Diabetes mellitus
    (Project Heads Endl, Josef ; Kummer, Udo ; Schendel, Ph.D., Dolores J. )
  - Function and regulation of human Mediator complexes in nuclear networks
    (Project Head Meisterernst, Michael )
  - Genetic evolution of pre-germinal center B cell lymphomas in transgenic mice with the focus on Mantle Cell Lymphoma
    (Project Heads Rad, Roland ; Zimber-Strobl, Ursula )
  - Genetische Risikostrukturen und Gen-Umwelt-Interaktion
    (Project Head Bickeböller, Heike )
  - Identifizierung von Minor-Histokompatibilitäts-Antigenen für die Behandlung des Leukämie-Rezidivs
    (Project Heads Bornkamm, Georg Wilhelm ; Mautner, Josef )
  - Identifizierung von Signalmolekülen des LMP1 Onkogens von Epstein-Barr Virus mit Hilfe von "functional proteomics"
    (Project Head Kieser, Arnd )
  - Inaktivierung des humanen RBP-J Gens in somatischen B-Zellinien durch Insertionsmutagenese über homologe Rekombination, dem Gene Targeting
    (Project Head Kempkes, Bettina )
  - Inaktivierung des humanen RBP-J Gens in somatischen B-Zellinien durch Insertionsmutagenese über homologe Rekombination, dem Gene Targeting
    (Project Head Kempkes, Bettina )
  - KIR-MHC-Interaktionen als Regulatoren der zytotoxischen Aktivität von NK- und T-Zellen
    (Project Head Schendel, Ph.D., Dolores J. )
  - Mathematical Methods for Analysis and Synthesis of Complex Data from Different Experiments
    (Project Heads Graf zu Castell-Rüdenhausen, Wolfgang ; Filbir, Frank-Dieter ; Lasser, Rupert )
  - Metabolic Imaging in Cancer Cachexia
    (Project Heads Berriel Diaz, Mauricio ; Herzig, Stephan ; Karampinos, Ph.D., Dimitrios )
  - Methoden der genetischen Epidemiologie zur Analyse von Haplotyp-Risikostrukturen
    (Project Heads Heid, Iris M. ; Illig, Thomas ; Kronenberg, Florian ; Wichmann, Heinz-Erich )
  - Modelling cost-benefit relations of carbon and nitrogen allocation in the plant-rhizosphere system
    (Project Head Priesack, Eckart )
  - Molecular control of hematopoietic stem cell self renewal and differentiation
    (Project Head Schroeder, Ph.D., Timm )
  - Molekularbiologische Untersuchungen zur Pathogense des Plattenepithelkarzinoms
    (Project Heads Balling, Ph.D., Rudi ; Höfler, Heinz )
  - Molekulare und funktionelle Analysae der Expression aktivierender und inhibitiorscher NK-Rezeptoren auf peripheren und infiltrierenden T-Lymphozyten am Beispiel der Psoriasis vulgaris
    (Project Head Falk, Christine )
  - Morphologische Analyse von Genexpressions Daten
    (Project Heads Beckers, Johannes ; Liebscher, Volkmar ; Winkler, Gerhard ; Wittich, Olaf )
  - Multimodal treatment and molecular determinants of cachexia in PDAC
    (Project Heads Berriel Diaz, Mauricio ; Herzig, Stephan )
  - Nucleolar targets of chemotherapy involved in cell cycle and growth control
    (Project Head Eick, Dirk )
  - Production of monoclonal antibodies
    (Project Head Kremmer, Elisabeth )
  - Proteome based analysis and molecular imaging of tumour metabolism for identification of targets for response prediction and assessment of prognosis in gastric cancer
    (Project Heads Ebert, Matthias ; Herrmann, Ken ; Walch, Axel Karl )
  - Regulation der Virussynthese des Epstein-Barr Virus
    (Project Head Hammerschmidt, Wolfgang )
  - Regulation of immunoglobulin gene conversion and hypermutation
    (Project Head Buerstedde, Jean-Marie )
  - Rekombinante Hitzeschockproteine (HSP) 70 als immunmodulatorische Mediatoren im "Cross-Talk" von dendritischen Zellen mit T-Zellen und NKZellen
    (Project Heads Issels, Rolf D. ; Nößner, Elfriede )
  - RNA-pulsed Dendritic Cells as Vaccines for Immune Therapy of Metastatic Renal Cell Carcinoma
    (Project Head Schendel, Ph.D., Dolores J. )
  - Role of human ORC in preparing origins for pre-replicative complex formation
    (Project Head Schepers, Aloys )
  - Schnelle Generierung von T-Zellen mit multipler Virusspezifität
    (Project Heads Hammerschmidt, Wolfgang ; Kolb, Hans-Jochem ; Moosmann, Andreas )
  - SFB 386: Statistical Analysis of Discrete Structures: Modelling and Application in Biometrics and Econometrics
    (Spokesperson Fahrmeir, Ludwig )
  - SFB 455: Viral Functions and Immunomodulation
    (Spokesperson Koszinowski, Ulrich H. )
  - SFB 571: Autoimmune Reactions: From Manifestations and Mechanisms to Therapy
    (Spokesperson Hohlfeld, Reinhard )
  - SFB 596: Molecular Mechanisms of Neurodegeneration
    (Spokesperson Haass, Christian )
  - SFB 607: Growth or Parasite Defense? Competition for Resources in Economic Plants from Agronomy and Forestry
    (Spokesperson Matyssek, Rainer )
  - SFB 646: Networks in Genome Expression and Maintenance
    (Spokespersons Beckmann, Roland ; Cramer, Patrick )
  - SFB 684: Molecular Mechnisms of Normal and Malignant Hematopoiesis
    (Spokespersons Bohlander, Stefan Klaus ; Hiddemann, Wolfgang )
  - SFB 824: Imaging for Selection, Monitoring and Individualisation of Cancer Therapies
    (Spokesperson Schwaiger, Markus )
  - SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing
    (Spokesperson Grothe, Benedikt )
  - SFB 924: Molecular Mechanisms Regulating Yield and Yield Stability in Plants
    (Spokesperson Schwechheimer, Claus )
  - SFB 1035: Control of Protein Function by Conformational Switching
    (Spokesperson Buchner, Johannes )
  - SFB 1118: Reactive metabolites as a cause of diabetes complications
    (Spokespersons Herzig, Stephan ; Nawroth, Peter ; Szendrödi, Julia )
  - SFB 1243: Genetic and Epigenetic Evolution of Hematopoietic Neoplasms
    (Spokesperson Leonhardt, Heinrich )
  - SFB 1253: Catchments as Reactors: Metabolism of Pollutants on the Landscape Scale (CAMPOS)
    (Spokesperson Grathwohl, Peter )
  - SFB 1321: Modelling and Targeting Pancreatic Cancer
    (Spokesperson Schmid, Roland M. )
  - SFB 1335: Aberrant Immune Signals in Cancer
    (Spokesperson Ruland, Jürgen )
  - The effect of TRAIL on primary leukemia cells and leukemic stem cells
    (Project Head Jeremias, Ph.D., Irmela )
  - The role of Notch-signaling in B cell development, activation and lymphomagenesis
    (Project Head Zimber-Strobl, Ursula )
  - The role of the germinal center kinase family member TNIK in hematopoiesis and signaling
    (Project Head Kieser, Arnd )
  - Veränderungen von Photosynthese und Membranfunktionen unter dem Einfluß von Luftbelastungen und erhöhter N-Versorgung bei Buchen und Fichten
    (Project Head Lütz, Cornelius )
CRC/Transregios
- Current projects
  - Integrated Research Training Group
    (Project Heads Berod, Ph.D., Luciana ; Daniel, Carolin )
  - Mass spectrometry and computational RNA biology platform
    (Project Heads Marsico, Annalisa ; Meitinger, Thomas ; Wittig, Ilka )
  - Novel pharmacotherapies for the treatment of central hypothyroidism associated with Mct8/Oatp1c1 deficiency
    (Project Heads Müller, Timo ; Pfluger, Paul )
  - Role and regulation of muscle-residing Foxp3+ Treg cells in health and disease
    (Project Head Daniel, Carolin )
  - Role of TRP channels in the systemic regulation of energy and glucose metabolism
    (Project Heads Khajavi, Noushafarin ; Müller, Timo ; Tschöp, Matthias )
  - TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
    (Spokesperson Gudermann, Thomas )
  - TRR 179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection
    (Spokesperson Bartenschlager, Ralf Friedrich Wilhelm )
  - TRR 205: The Adrenal: Central Relay in Health and Disease
    (Spokesperson Bornstein, Ph.D., Stefan R. )
  - TRR 274: Checkpoints of Central Nervous System Recovery
    (Spokespersons Flügel, Alexander ; Simons, Mikael Jakob )
  - TRR 296: Local control of TH action (LocoTact)
    (Spokesperson Führer-Sakel, Dagmar )
  - TRR 353: Regulation of cell death decisions
    (Spokesperson Brunner, Thomas )
  - TRR 356: Genetic diversity shaping biotic interactions of plants (PlantMicrobe)
    (Spokesperson Parniske, Martin )
  - TRR 359: Perinatal Development of Immune Cell Topology
    (Spokesperson Henneke, Philipp )
  - TRR 387: Functionalizing the Ubiquitin System against Cancer - UbiQancer
    (Spokesperson Bassermann, Florian )
- Completed projects
  - CD30 Signaling in normal B Cell Development and Tumorigenesis
    (Project Heads Bornkamm, Georg Wilhelm ; Zimber-Strobl, Ursula )
  - Control of DNA replication by epigenetic modification and chromatin remodelling
    (Project Head Schepers, Aloys )
  - Core facility for the construction and characterization of T cell receptor gene-modified T lymphocytes
    (Project Heads Frankenberger, Bernhard ; Schendel, Ph.D., Dolores J. ; Uckert, Wolfgang )
  - Core Facility monoclonal antibodies fpr CRC TRR 5
    (Project Head Kremmer, Elisabeth )
  - Drug-induced Apoptosis and Senescence: Interaction with the adaptive Immune System in c-myc induced murine B Cell Lymphomas
    (Project Heads Bornkamm, Georg Wilhelm ; Gerbitz, Armin ; Schmitt, Clemens A. )
  - EBV/CMV bi-specific T cells for adoptive therapy
    (Project Heads Hammerschmidt, Wolfgang ; Moosmann, Andreas )
  - Functional Plasticity of hypermutating B Cell Lymphomas
    (Project Head Jungnickel, Berit )
  - Function of transcription coactivator complexes in chromatin
    (Project Head Meisterernst, Michael )
  - Identification of allorestricted T-cell receptors with specificity for tumor-associated antigens in B non-Hodgkin lymphoma using chronic lymphocytic leukemia as a model
    (Project Heads Krackhardt, Angela ; Mocikat, Ralph )
  - Integrated Research Training Group
    (Project Heads Kammertoens, Thomas ; Nößner, Elfriede ; Uckert, Wolfgang )
  - Kinetics of chromatin formation and CpG methylation of Epstein-Barr Virus DNA
    (Project Head Hammerschmidt, Wolfgang )
  - Niche Function of immature osteoblastic Cells for lymphatic Tumor Cells
    (Project Head Kieslinger, Matthias )
  - Outer membrane vesicles in SARS-CoV2-bacteria co-infection
    (Project Heads Marsico, Annalisa ; Schmeck, Bernd ; Vingron, Martin )
  - Selection of allo-restricted peptide-specific T cells for adoptive therapy of acute leukemia
    (Project Heads Frankenberger, Bernhard ; Schendel, Ph.D., Dolores J. )
  - Study of RNA polymerase II functions required for transcription of chromatin templates
    (Project Head Eick, Dirk )
  - T cell receptor gene transfer in CD4+ and CD8+ T cells for adoptive therapy of renal cell carcinomas
    (Project Heads Nößner, Elfriede ; Uckert, Wolfgang )
  - The human c-MYC-gene-product as target antigen in a murine model of high grade B cell lymphoma
    (Project Heads Bornkamm, Georg Wilhelm ; Gerbitz, Armin ; Mautner, Josef )
  - TRR 5: Chromatin - Assembly and Inheritance of Functional States
    (Spokesperson Becker, Peter Burkhard )
  - TRR 54: Growth and Survival, Plasticity and Cellular Interactivity of Lymphatic Malignancies
    (Spokesperson Dörken, Bernd )
Research Grants
- Current projects
- Completed projects
Research Units
- Current projects
  - FOR 5795: HyperMet: Effects of skeletal muscle hypertrophy and atrophy on metabolic health
    (Spokesperson Wackerhage, Henning )
  - HyperImaGene. Metabolic mechanisms that cause fat loss due to semaglutide versus muscle hypertrophy
    (Applicants Dragano, Ph.D., Nathalia ; Hrabe de Angelis, Martin ; Schilling, Franz )
- Completed projects
  - Effects of emotional context and tactile stimulation on the placebo response in a nausea model
    (Applicant Meißner, Karin )
Priority Programmes
- Current projects
  - Addressing the generalizability crisis with large language models
    (Applicant Wulff, Dirk )
- Completed projects
  - Development of T3-peptide ligands to treat MCT8 deficiency via a Trojan horse like mechanism
    (Applicants Krude, Heiko ; Tschöp, Matthias )
International Research Training Groups
- Completed projects
  - GRK 1563: Regulation and Evolution of Cellular Systems
    (Spokespersons Frishman, Dmitrij ; Zimmer, Ralf )
Research Training Groups
- Current projects
  - GRK 2679: Urban Green Infrastructure – Training Next Generation Professionals for Integrated Urban Planning Research
    (Spokesperson Pauleit, Stephan )
- Completed projects
  - GRK 2274: Advanced Medical Physics for Image-Guided Cancer Therapy
    (Spokesperson Parodi, Katia )
Graduate Schools
- Completed projects
  - GSC 82: Graduate School Of Systemic Neurosciences (GSN-LMU)
    (Spokesperson Grothe, Benedikt )
  - GSC 1006: Graduate School of Quantitative Biosciences Munich (QBM)
    (Spokesperson Frey, Erwin )
Clusters of Excellence
- Completed projects
  - EXC 114: Munich Center for Integrated Protein Science (CIPSM)
    (Spokesperson Carell, Thomas )
  - EXC 158: Munich-Centre for Advanced Photonics (MAP)
    (Spokesperson Krausz, Ph.D., Ferenc )
  - EXC 1010: Munich Cluster for Systems Neurology (SyNergy)
    (Spokesperson Haass, Christian )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2145: Munich Cluster for Systems Neurology (SyNergy)
    (Spokespersons Haass, Christian ; Misgeld, Thomas )
NFDI technical and methodological consortia
- Current projects
  - DataPLANT – Data in PLANT research
    (Spokesperson von Suchodoletz, Dirk )
  - GHGA – German Human Genome-Phenome Archive
    (Spokesperson Stegle, Ph.D., Oliver )
  - NFDI4Health – National Research Data Infrastructure for Personal Health Data
    (Spokesperson Fluck, Juliane )
  - NFDI4Microbiota - National Research Data Infrastructure for Microbiota Research
    (Spokesperson Förstner, Konrad )

Subinstitutions

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