Technische Universität München (TUM)
Fakultät für Medizin
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
Address
Trogerstraße 30
81675 München
Deutschland
GERiT
This institution in GERiT
81675 München
Projects
Research Grants
Current projects
Assessing the effect of maternal helminth infection on Vitamin D regulation and on the immune system of the infant (HELMVIT)
(Applicant
Prazeres da Costa, Clarissa
)
Effect of Helicobacter pylori eradication and microbiome manipulation on colorectal cancer development
(Applicants
Deng, Li
;
Gerhard, Markus
)
Immunomodulation of vaccine-induced CD8+ T cell responses through early life exposure to chronic maternal schistosomiasis
(Applicant
Prazeres da Costa, Clarissa
)
Mechanisms of immune regulatory and inflammatory host-parasite interaction in neurocysticercosis
(Applicant
Prazeres da Costa, Clarissa
)
Structural and functional consequences of the CEACAM-HopQ mediated binding of Helicobacter pylori to human gastric epithelial cells in vitro and in vivo
(Applicants
Gerhard, Markus
;
Wennemuth, Gunther
)
Completed projects
Activation of alternative NF-kB signaling in the stomach: link to H. pylori virulence factors and effect on gastric inflammation and gastric pathogenesis
(Applicants
Gerhard, Markus
;
Heikenwälder, Mathias
)
Analyse der Rolle von Zielgenen des Wnt Signalweges in der Entwicklung und Tumorentstehung
(Applicant
Gerhard, Markus
)
Analysis of schistosomicidal component(s) within mouse serum and its implications for novel drug development
(Applicant
Prazeres da Costa, Clarissa
)
Employment of CEA-related cell adhesion molecules (CEACAMs) by Helicobacter pylori
(Applicants
Gerhard, Markus
;
Singer, Bernhard B.
)
Identification and validation of H. pylori-associated gastric cancer biomarkers in Chinese and German populations
(Applicant
Gerhard, Markus
)
Maternal helminth infection: Immunological and developmental consequences for the offspring
(Applicant
Prazeres da Costa, Clarissa
)
Molecular control of brite adipogenesis: Identification of novel cell surface markers, transcriptional regulators and functional components
(Applicant
Klingenspor, Martin
)
Resolving molecular networks and dynamics of individual T cells in chronic infections
(Applicant
Busch, Dirk
)
The function of the essential Helicobacter pylori virulence factor gamma-glutamyltranspeptidase for gastric colonization and immune response in vivo
(Applicant
Gerhard, Markus
)
The interaction of Hepatitis B virus infection and Schistosomiasis in chronic pathogen-induced liver inflammation
(Applicants
Prazeres da Costa, Clarissa
;
Protzer, Ulrike
)
The role and interaction of Treg cells during schistosomiasis
(Applicant
Prazeres da Costa, Clarissa
)
The stem cell ubiquitin ligase RNF43 in gastric homeostasis, DNA damage response and carcinogenesis: from biological function to application as biomarker
(Applicant
Gerhard, Markus
)
Collaborative Research Centres
Current projects
T cell skewing in relation to intestinal dysbiosis and GvHD in allogeneic stem cell transplantation
(Project Heads
Busch, Dirk
;
Holler, Ernst
;
Meedt, Elisabeth
)
Completed projects
Analysis of immune-regulatory effects of NKG2D-ligands
(Project Head
Busch, Dirk
)
Antigen- and leukocyte-trafficking events guiding effective CD8+T lymphocyte differentiation
(Project Heads
Busch, Dirk
;
Verschoor, Ph.D., Admar
)
Cell Sorting Unit for the identification and purification of leukocytes, stem cells and tumor cells
(Project Head
Busch, Dirk
)
Deciphering cell fate decisions of single NK cells during infection
(Project Head
Buchholz, Veit
)
Ex vivo quantification of the interplay between innate and adaptive immune cells leading to protective immunity
(Project Head
Busch, Dirk
)
Helicobacter infection and microbiota-dependent colonic pathologies
(Project Heads
Deng, Li
;
Gerhard, Markus
)
Neo-epitopes derived from mutated tumor suppressor gene RNF43 as targets for adoptive T cell therapy in pancreatic cancer
(Project Heads
Busch, Dirk
;
Gerhard, Markus
)
Role of Helicobacter pylori ã-Glutamyltranspeptidase for immune evasion
(Project Head
Gerhard, Markus
)
SFB 456: Target Structures for Selective Tumor Interventions
(Spokespersons
Busch, Dirk
;
Wagner, Hermann
)
Tracking T cell receptor-dependent imprinting of cellular differentiation states during polyclonal and chronic immune responses
(Project Heads
Buchholz, Veit
;
Busch, Dirk
;
Schober, Kilian
)
Major Research Instrumentation
Completed projects
Highspeed cell sorter (for S1)
Highspeed cell sorter (for S2)
CRC/Transregios
Current projects
Central Tasks of the Collaborative Research Center
(Project Head
Busch, Dirk
)
Engineering CAR-T cells to optimize the treatment of cerebral malignancies
(Project Heads
von Baumgarten, Louisa
;
Buchholz, Veit
)
High-resolution multiparametric cell and tissue analysis & establishment of a spatially resolved cell atlas of the chronically hepatitis B virus infected liver
(Project Heads
Andrä, Immanuel Anton
;
Bauer, Tanja
;
Bengsch, Ph.D., Bertram
;
Eils, Roland
;
Mogler, Carolin
;
Neumann-Haefelin, Christoph
;
Schiemann, Matthias
)
Orthotopic T cell receptor replacement by advanced non viral cell engineering
(Project Head
Busch, Dirk
)
Tissue-derived eicosanoids as modulators of Treg cell induction, stability and function
(Project Heads
Esser-von Bieren, Julia
;
Prazeres da Costa, Clarissa
)
TRR 338: LETSIMMUN - Lymphocyte Engineering for Therapeutic Synthetic Immunity
(Spokesperson
Busch, Dirk
)
Completed projects
Allergy-suppressive properties of helminth antigens and transgenerational effects of helminth infection on allergic airway inflammation
(Project Head
Prazeres da Costa, Clarissa
)
Central Tasks
(Project Heads
Blankenstein, Thomas
;
Busch, Dirk
;
Schendel, Ph.D., Dolores J.
)
Graft versus leukaemia upon T cell transfer in patients with acute myeloid leukaemia and stem cell transplantation
(Project Heads
Borkhardt, Arndt
;
Busch, Dirk
;
Kolb, Hans-Jochem
)
Immunological characterization of human donor-derived pathogen-specific T cells for adoptive T cell therapy
(Project Heads
Busch, Dirk
;
Neuenhahn, Michael
)
Improved MHC multimer-based single cell analyses for the identification of TCR sequences with "optimal high avidity" for immunotherapy
(Project Head
Busch, Dirk
)
Research Training Groups
Current projects
GRK 2668: Immune Master Switches in Allergies and Autoimmune Diseases
(Spokesperson
Biedermann, Tilo
)
