Goethe-Universität Frankfurt am Main
Universitätsklinikum
Institut für Klinische Pharmakologie
Address
Theodor-Stern-Kai 7
60596 Frankfurt am Main
Deutschland
GERiT
This institution in GERiT
60596 Frankfurt am Main
Projects
Research Grants
Current projects
Does CerS3 in CD4+ T cells represent a new target for treating chronic inflammation and/or autoimmune diseases?
(Applicant
Grösch, Sabine
)
Fatty Acid Synthase and lipophagy as therapeutic targets of glioblastoma
(Applicants
Kögel, Donat
;
Tegeder, Irmgard
)
Generative artificial intelligence-based algorithm to increase the predictivity of preclinical studies while keeping sample sizes small
(Applicant
Lötsch, Jörn
)
Identification and characterization of a novel human oxygenase responsible for the formation of 15(R)-HETE and 17(R)-HDHA in tumor cells and neutrophil granulocytes
(Applicant
Kahnt, Astrid
)
Investigation on the pharmacological aspects underlying the antidiabetic effects of a thromboxane receptor (TP) antagonist
(Applicants
Offermanns, Stefan
;
Scholich, Klaus
)
Completed projects
Characterisation of peripheral and central effects of opioid and non-opioid analgesis via microdialysis in human beings
(Applicant
Geißlinger, Gerd
)
Differenzielle Wirkungen von Cannabis auf Schmerz
(Applicant
Lötsch, Jörn
)
Effect of selective interventions on the spatial organization of an inflammation
(Applicant
Scholich, Klaus
)
Elucidation of the cyclooxygenase-dependent kidney development in the mouse
(Applicant
Nüsing, Rolf Michael
)
Enzymes of the sphingolipid metabolism as potential prognostic markers for breast cancer patients - and the impact of a anti-hormone therapy
(Applicant
Wegner, Marthe-Susanna
)
Funktionelle Konsequenzen eines spinalen Prostaglandinshifts nach mPGES-1-Deletion
(Applicant
Geißlinger, Gerd
)
Funktionen der IkappaB Kinase beta (IKKbeta) in Neuronen der Dorsalganglien
(Applicant
Tegeder, Irmgard
)
Influence of altered life conditions on the regulation of AMP-activated kinase (AMPK) in inflammatory pain
(Applicant
Niederberger, Ellen
)
INtraCELLular delivery of PHOSphorylated tools to TAG proteins using next generation nucleoside triphosphate derivatives
(Applicant
Meier, Chris
)
Massenspektrometrische Analytik der Eicosanoide und ihrer Pharmakomodulatoren
(Applicant
Seyberth, Hannsjörg W.
)
Noninvasive central modulation of pain follwing TMS inhibition of the secondary somatosensory cortex in healthy subjects
(Applicant
Lötsch, Jörn
)
Populations-Pharmakokinetik und Pharmakodynamik von Morphin und Morphin-6-Glucuronid
(Applicant
Lötsch, Jörn
)
Potential Role of Brain Stem Extra-endothelial Activity of eNOS for the Regulation of Blood Pressure
(Applicant
Suvorava, Ph.D., Tatsiana
)
Regulation neuronaler Signaltransduktionswege durch PAM (Protein Associated with Myc) während der signalen Schmerzverarbeitung
(Applicant
Scholich, Klaus
)
Regulation of ceramide synthases in tumor cells and their effects on proliferation and apoptosis
(Applicant
Grösch, Sabine
)
Regulation of CerS4 un human colon cells and its role in colon carcinogenesis
(Applicant
Grösch, Sabine
)
The PGD2 system, a new target to treat type 1 diabetes
(Applicant
Nüsing, Rolf Michael
)
Untersuchungen zur Bedeutung der IkB Kinase epsilon für die Aktivierung des Transkriptionsfaktors NF-kappaB bei entzündlichen Schmerzreaktionen
(Applicant
Niederberger, Ellen
)
Zelluläre Mechanismen der antikanzerogenen Wirkung von nicht-steroidalen Antiphlogistika (NSAIDs)
(Applicant
Grösch, Sabine
)
Research Fellowships
Completed projects
Bedeutung des Vesikelproteins Synapsin II für die Entstehung und Chronifizierung von Schmerzen
(Applicant
Tegeder, Irmgard
)
The influence of an increased UDP-glucose ceramide glycosyltransferase (UGCG) gene expression on the development of hepatocellular carcinoma (HCC)
(Applicant
Wegner, Marthe-Susanna
)
Research Units
Completed projects
Crosstalk von Sphingolipiden, Prostanoiden und Endocannabinoiden bei der Nozizeption
(Applicant
Scholich, Klaus
)
Die Rolle von Ceramidsynthasen in der Brustkrebs-Kanzerogene
(Applicant
Grösch, Sabine
)
Quantifizierung von Lipidmediatoren mittels Tandem-Massenspektrometrie
(Applicant
Geißlinger, Gerd
)
Clinical Research Units
Completed projects
Assoziation von extra- und intrazellulären Virustatikakonzentrationen mit deren antiviralen Wikungen bei chronischer Hepatitis C
(Applicant
Lötsch, Jörn
)
Scientific Networks
Completed projects
Quality in bioanalysis of lipid mediators
(Applicant
Thomas, Dominique
)
Collaborative Research Centres
Current projects
Central Tasks of the Collaborative Research Centre
(Project Heads
Geißlinger, Gerd
;
Pfeilschifter, Josef M.
)
CerS in colon cancer: Influence on T-cells and tumor environment
(Project Head
Grösch, Sabine
)
INFLUENCE OF A LOCAL INFLAMMATION ON LIPIDSYNTHESIS AND -SIGNALING IN MEGAKARYOCYTES AND THROMBOCYTES
(Project Heads
Geißlinger, Gerd
;
Scholich, Klaus
)
Integrated Research Training Group
(Project Heads
Meyer zu Heringdorf, Dagmar
;
Radeke, Heinfried H.
;
Tegeder, Irmgard
)
Lipids synthesized via CYP-Epoxygenases in chronic inflammatory and neuropathic pain states
(Project Head
Sisignano, Marco
)
Role of glucosylceramides for Parkinson's Disease associated polyneuropathy and pain
(Project Head
Tegeder, Irmgard
)
Selective and sensitive quantification of lipid mediators and lipids using LC-MS/MS and LC-HRMS
(Project Head
Geißlinger, Gerd
)
Completed projects
Adaptive cellular mechanisms of functional reorganization and recovery after traumatic brain injury (TBI)
(Project Heads
Mittmann, Thomas
;
Tegeder, Irmgard
)
EGFL7 and progranulin (PRGN) in neurogenesis: a notch above as a duo in neural homeostasis.
(Project Heads
Schmidt, Mirko H.H.
;
Schwarzacher, Stephan
;
Tegeder, Irmgard
)
Integrated Research Training Group
(Project Heads
Brandes, Ralf P.
;
Tegeder, Irmgard
)
Nox4-dependent mechanisms in neuropathic pain and pruritus signaling cascades
(Project Heads
Geißlinger, Gerd
;
Kallenborn-Gerhardt, Wiebke
)
Nucleoredoxin as regulator of neuronal activity and plasticity
(Project Head
Tegeder, Irmgard
)
Progranulin in the Adaptive Response of the Nociceptive System to Damage
(Project Head
Tegeder, Irmgard
)
Protein engineering of sensors and modulators of autophagy
(Project Head
Ernst, Andreas
)
Schmerzrelevante cGMP-Proteinkinase-abhängige und -unabhängige Effekte von NO
(Project Heads
Geißlinger, Gerd
;
Niederberger, Ellen
)
Major Research Instrumentation
Completed projects
High resolution mass-spectrometer
Tandem-Massenspektrometer
Tandem-Massenspektrometer mit HPLC-Komponenten (LC-MS/MS)
International Research Training Groups
Completed projects
GRK 757: Roles of Eicosanoids in Biology and Medicine
(Spokesperson
Steinhilber, Dieter
)
Research Training Groups
Current projects
GRK 2336: Resolution of inflammation – Mediators, signaling and therapeutic options
(Spokesperson
Weigert, Andreas
)
Completed projects
GRK 1172: Research, Development and Safety of Biologicals
(Spokesperson
Pfeilschifter, Josef M.
)
