Goethe-Universität Frankfurt am Main
Universitätsklinikum
Institut Biochemie II
Address
Theodor-Stern-Kai 7
60596 Frankfurt am Main
Deutschland
GERiT
This institution in GERiT
60596 Frankfurt am Main
Projects
Research Grants
Current projects
Characterizing the function of SUMO-targeted ubiquitin networks in coordinating nuclear and cytosolic protein quality control pathways
(Applicant
Müller, Stefan
)
Development of 3Cs fixed-pair for pooled DNA excisions with single-cell transcriptomic read outs.
(Applicants
Kaulich, Ph.D., Manuel
;
Looso, Mario
)
Directional dependencies of chemo-resistant lung cancer.
(Applicants
Kaulich, Ph.D., Manuel
;
Looso, Mario
)
SUMOylation in Lymphoma: Mechanisms and Therapeutic Targeting of the SENP6-RNF4 Axis
(Applicants
Keller, Ulrich
;
Müller, Stefan
)
Ubiquitin pathway modulation to enhance prime editing efficiencies.
(Applicants
Husnjak, Ph.D., Koraljka
;
Kaulich, Ph.D., Manuel
)
Completed projects
Acetylation of SUMO paralogs as a determinant of SUMO-mediated protein networks
(Applicant
Müller, Stefan
)
Characterisation of PIAS proteins as E3-like SUMO-ligases of p53 and c-Jun
(Applicant
Müller, Stefan
)
ER-associated protein degradation (ERAD): The machinery for recognition, retro-translocation and degradation of misfolded proteins of the ER
(Applicant
Stolz, Alexandra
)
Functional analysis of the adaptor protein CIN85 and its isoforms in vivo
(Applicant
Dikic, Ivan
)
Functional analysis of ubiquitin-binding proteins in vivo
(Applicant
Dikic, Ivan
)
Functional role of SUMO modification in the retinoflastoma tumour suppressor pathway
(Applicant
Müller, Stefan
)
The vital interplay of acyl-carrier proteins and LYR proteins (ACPM-LYRM) in mitochondria
(Applicant
Angerer, Heike
)
Ubiquitin and Ub-like interactomes in regulation of cellular functions
(Applicant
Dikic, Ivan
)
Priority Programmes
Completed projects
Function of the UBZ-containing ATPase Wrnip1 in DNA replication and damage response
(Applicant
Dikic, Ivan
)
Protein networks involved in biogenesis of the Salmonella proliferative niche
(Applicant
Dikic, Ivan
)
Regulatory functions of the SUMO system in ribosome biogenesis and mitosis
(Applicant
Müller, Stefan
)
Emmy Noether Independent Junior Research Groups
Completed projects
Novel physiological roles for atypical K11-linked ubiquitin chains
(Applicant
Bremm, Anja
)
Research Units
Current projects
FOR 2625: Mechanisms of Lysosomal Homeostasis
(Spokesperson
Braulke, Thomas
)
Ubiquitination in regulation of lysosome functions
(Applicants
Bremm, Anja
;
Dikic, Ivan
)
Completed projects
Caveolin-associated proteins and endothelial signalling
(Applicant
Müller-Esterl, Werner
)
Research Fellowships
Completed projects
Structural and functional analysis of K11-linked ubiquitin chains and the deubiquitinase Cezanne in the HIF signaling pathway and the cellular adaptation to hypoxia.
(Applicant
Bremm, Anja
)
Major Research Instrumentation
Completed projects
4-laser cell sorter
Confocal Laser Scanning microscope
High Resolution Screening Microscope
Hybrid-FT-Massenspektrometer
Quantitative high-throughput spinning-disk confocal microscope
Spinning disk confocal microscope
Collaborative Research Centres
Current projects
Bacterial evasion of selective autophagy pathways
(Project Heads
Dikic, Ivan
;
Dötsch, Volker
)
Central tasks of the CRC
(Project Head
Dikic, Ivan
)
Imaging and phenotypical screening platform
(Project Heads
Eimer, Stefan
;
Heilemann, Mike
;
Pohl, Christian
;
Stolz, Alexandra
;
Wilfling, Florian
)
Integrated Research Training Group (IRTG)
(Project Heads
Behl, Christian
;
Bremm, Anja
;
Dötsch, Volker
;
Pohl, Christian
)
Molecular principles guiding lipid structure and function of autophagosomes
(Project Heads
Bhaskara, Ph.D., Ramachandra M.
;
Kern, Andreas
;
Pohl, Christian
)
Pexophagy and mitophagy in cellular homeostasis, aging and disease
(Project Heads
Bremm, Anja
;
Eimer, Stefan
)
Quantitative proteomics and integrated systems biology
(Project Heads
Behrends, Ph.D., Christian
;
Beli, Petra
;
Bhaskara, Ph.D., Ramachandra M.
;
Dikic, Ivan
;
Hummer, Gerhard
;
Münch, Christian
)
Regulation of aggrephagy by co-chaperones and assisting proteins
(Project Heads
Behl, Christian
;
Heilemann, Mike
;
Kaulich, Ph.D., Manuel
)
Regulation of autophagy by microproteins and RNA modifications
(Project Heads
Dikic, Ivan
;
Kaiser, Stefanie
)
Regulatory mechanisms and dynamics of ER-phagy receptors clustering
(Project Heads
Heilemann, Mike
;
Stolz, Alexandra
)
Role of SPRTN in resolution of DNA protein crosslinks and replication stress
(Project Head
Dikic, Ivan
)
SFB 1177: Molecular and Functional Characterization of Selective Autophagy
(Spokesperson
Dikic, Ivan
)
Vascular damage control by deubiquitinases
(Project Heads
Dikic, Ivan
;
Potente, Michael
)
Completed projects
Autophagy in ribosome biogenesis and quality control
(Project Head
Müller, Stefan
)
Chemical and genomic screening
(Project Heads
Kaulich, Ph.D., Manuel
;
Stolz, Alexandra
)
Deubiquitinating enzymes in selective autophagy
(Project Heads
Beli, Petra
;
Bremm, Anja
)
Functional Characterization of AML-associated Mutants of Nucleophosmin
(Project Head
Müller, Stefan
)
Function and regulation of the SUMO system during hypoxia
(Project Head
Müller, Stefan
)
Molecular principles of ER-phagy pathways
(Project Heads
Dikic, Ivan
;
Hummer, Gerhard
)
Molekulare Mechanismen der NO-vermittelten Hemmung der Thrombozytenaggregation
(Project Head
Smolenski, Albert
)
Regulation der löslichen Guanylylcylase durch posttranslationale Modifikationen und akzessorische Proteine
(Project Head
Gross, Steffen
)
Regulatory interplay between autophagosomal and endosomal pathways
(Project Head
Dikic, Ivan
)
Serine ubiquitination and regulation of autophagy upon Legionella
(Project Heads
Dikic, Ivan
;
Heilemann, Mike
)
DIP Programme
Current projects
Understanding and targeting degradation-resistant cancers
(Applicants
Brik, Ph.D., Ashraf
;
Dikic, Ivan
)
CRC/Transregios
Current projects
Discovery and targeting of ubiquitin-dependent synthetic vulnerabilities in NSCLC
(Project Heads
Kaulich, Ph.D., Manuel
;
Rad, Roland
)
Function and targeting of membrane-bound E3 ligases in AML
(Project Heads
Dikic, Ivan
;
Krause, Daniela
)
Integrated Research Training Group
(Project Heads
Bremm, Anja
;
Büchel, Gabriele
)
Reprogramming of the E3 ligase/DUB network during oncogenic transformation
(Project Heads
Diefenbacher, Markus Elmar
;
Dikic, Ivan
)
Target and compound profiling
(Project Heads
Schülein-Völk, Christina
;
Stolz, Alexandra
;
Wilhelm, Stephanie
)
Targeting E3 ligase functions in AML
(Project Heads
Knapp, Stefan
;
Müller, Stefan
)
Targeting the oxidative stress response of non-small cell lung cancers
(Project Head
Bremm, Anja
)
Clusters of Excellence
Completed projects
EXC 115: Macromolecular Complexes
(Spokespersons
Dötsch, Volker
;
Schwalbe, Harald
)
Clusters of Excellence (ExStra)
Current projects
EXC 2026: Cardio-Pulmonary Institute (CPI)
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
)
