Universitätsklinikum Münster
Klinik für Neurologie
mit Institut für Translationale Neurologie
Address
Albert-Schweitzer-Campus 1
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Priority Programmes
Completed projects
Charakterisierung residenter endoneuronaler Makrophagen in vivo im Vergleich mit Mikroglia und perivaskulären Zellen des Gehirns
(Applicant
Kiefer, Reinhard
)
Research Grants
Current projects
AntibodyOMICs in CASPR2 Encephalitis
(Applicant
Lünemann, Jan
)
Autophagy in Microglia-mediated De- and Re-myelination
(Applicant
Lünemann, Jan
)
Clinician Scientist CareerS Münster
(Applicant
Schäfers, Michael
)
Next-generation immunological analysis of a cohort of monozygotic twins discordant for Multiple Sclerosis diagnosis.
(Applicants
Klotz, Luisa
;
Schwab, Ph.D., Nicholas
)
Origin, fate, and function of meningeal mature and progenitor B cells.
(Applicant
Meyer zu Hörste, Gerd
)
Completed projects
Influence of environmental factors on the interplay of transcriptome and proteome in newly diagnosed Multiple Sclerosis patients
(Applicants
Schwab, Ph.D., Nicholas
;
Wiendl, Heinz
)
Kortikale DC Stimulation zur Therapie der schlaganfallbedingten Dysphagie - eine MEG-basierte Pilotstudie
(Applicant
Teismann, Inga Kristina
)
Mechanisms of nuclear receptor-mediated control of TH17 differntiation
(Applicant
Klotz, Luisa
)
Neurogene Dysphagie - Kortikale Reorganisation im Krankheitsverlauf und als Folge therapeutischer Interventionen
(Applicant
Pantev, Christo
)
Neurostimulation for the treatment of disturbed pharyngeal sensitivity as a major cause of neurogenic dysphagia
(Applicants
Dziewas, Rainer
;
Suntrup-Krüger, Sonja
;
Wolters, Carsten Hermann
)
Positional cloning of the genetic defect causing Hereditary Neuralgic Amyotrophy (HNA)
(Applicant
Kuhlenbäumer, Ph.D., Gregor
)
Rapid and deterministic generation of microglia from human pluripotent stem cells - an in vitro platform for disease progression in neurodegeneration and neuroinflammation
(Applicant
Pawlowski, Matthias
)
Single cell-based ultra high-resolution characterization of intrathecal immunity in Autoimmune Encephalitis
(Applicants
Leypoldt, Frank
;
Meyer zu Hörste, Gerd
)
Stress signaling in the interaction between innate and adaptive immunity in Multiple Sclerosis
(Applicants
Meyer zu Hörste, Gerd
;
Roth, Johannes
)
Susac syndrome (SuS) as a paradigm of a CD8 T-cell mediated endotheliopathy
(Applicant
Groß, Catharina C.
)
The role of NADPH oxidases in Multiple Sclerosis and its animal model, the experimental autoimmune encephalomyelitis
(Applicants
Göbel, Kerstin
;
Meuth, Sven G.
)
The role of natural killer cells (NK) in the immunoregulation of multiple sclerosis (MS)
(Applicant
Groß, Catharina C.
)
The role of NOX4 and its interaction with mitochondria and Nrf2 in hyperexcitability-induced neurodegeneration
(Applicant
Kovac, Ph.D., Stjepana
)
The role of the nuclear receptor NR4A1 in acute ischemic stroke: pathophysiology, therapeutic evaluation and human translation
(Applicants
Klotz, Luisa
;
Minnerup, Jens
)
The role of the two pore-domain potassium channel TASK1 in oligodendroglial maturation and myelin regeneration
(Applicants
Albrecht, Stefanie
;
Hundehege, Petra
)
Heisenberg Grants
Current projects
Understanding lymphocytes in nervous system border-associated compartments
(Applicant
Meyer zu Hörste, Gerd
)
Research Fellowships
Completed projects
Autophagy-mediated antigen presentation for CD1d-restricted NKT cell recognition
(Applicant
Keller, Christian
)
Freisetzung von Neuromodulatoren nach Transfektion mit lentiviralen Vektoren zur Behandlung fokaler therapierefraktärer Epilepsien des Neokortex: Untersuchungen am Tetanustoxin-Modell der Ratte
(Applicant
Kovac, Ph.D., Stjepana
)
Induction of oligodendrocyte lineage cells by direct cellular reprogramming.
(Applicant
Pawlowski, Matthias
)
Mechanism of interleukin-27 mediated inhibition of Th17 cells in experimental autoimmune encephalomyelitis.
(Applicant
Meyer zu Hörste, Gerd
)
Optimierung der Vakzinierungstherapie mit Tumorantigen-beladenen Dendritischen Zellen beim malignen Gliom
(Applicant
Grauer, Oliver
)
Wirkungsmechanismus der Interleukin-2 Rezeptor Alpha-Blockade in der Therapie der Multiplen Sklerose
(Applicant
Lünemann, Jan
)
Clinical Research Units
Current projects
KFO 342: Organ Dysfuncion During Systemic Inflammation
(Spokesperson
Zarbock, Alexander
)
Completed projects
Immune System variables in healthy subjects and during systemic inflammation
(Applicants
Klotz, Luisa
;
Rossaint, Jan
;
Roth, Johannes
)
Local control of inflammation neuronal damage by Peroxisome-profilator-activated receptory (PPARy) in EAE
(Applicant
Klotz, Luisa
)
Collaborative Research Centres
Completed projects
Mechanisms and consequences of immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier
(Project Heads
Klotz, Luisa
;
Wiendl, Heinz
)
Mechanisms of nuclear receptor-mediated control of TH17 cell differentiation
(Project Head
Klotz, Luisa
)
CRC/Transregios
Current projects
Dissecting the contribution of immune cell activation dependent neuronal connectivity changes to disease trajectories in depression
(Project Heads
Forstner, Andreas J.
;
Klotz, Luisa
;
Ziller, Michael J.
)
Neutrophil modulation during cerebral ischemia by the nuclear receptor NR4A1
(Project Heads
Klotz, Luisa
;
Minnerup, Jens
)
Completed projects
Analysis and therapeutic modifications of innate immune regulatory networks in controlling T-cell activation in MS
(Project Heads
Groß, Catharina C.
;
Wiendl, Heinz
)
Clinical translational Unit
(Project Heads
Fleischer, Vinzenz
;
Gold, Ralf
;
Hemmer, Bernhard
;
Hohlfeld, Reinhard
;
Klotz, Luisa
;
Kuhlmann, Tanja
;
Kümpfel, Tania
;
Lehmann-Horn, Klaus
;
Lüssi, Felix
;
Meyer zu Hörste, Gerd
;
Wiendl, Heinz
;
Zipp, Frauke
)
Immune regulation at the CNS barriers and in the CNS: role of immune cell trafficking
(Project Heads
Schwab, Ph.D., Nicholas
;
Zarbock, Alexander
)
Impact of diet and intestinal microbiota on the gut-CNS-axis – implications for CNS autoimmunity
(Project Heads
Klotz, Luisa
;
Schuppan, Detlef
)
MOG Antibody-Induced CNS Demyelination: from Specificity to Function
(Project Heads
Lünemann, Jan
;
Meinl, Edgar
)
Molecular mechanisms and sites of action of the gelatinases in autoimmune CNS inflammation: do MMP-2/-9 contribute to meningeal inflammation and secondary cortical damage?
(Project Heads
Meyer zu Hörste, Gerd
;
Schäfers, Michael
;
Sorokin, Lydia
)
Temporal lobe epilepsy and advenced white matter fractional anisotropy analysis
(Project Heads
Deppe, Michael
;
Elger, Christian E.
;
Weber, Bernd
)
The role of the kallikrein-kinin system to functional and structural impairment of network activity in multiple sclerosis
(Project Heads
Budde, Thomas
;
Göbel, Kerstin
;
Meuth, Sven G.
;
Pape, Hans-Christian
)
Research Units
Current projects
Chronic inflammasome activation in post-stroke recovery
(Applicants
Hornung, Veit
;
Liesz, Arthur
;
Schmidt-Pogoda, Antje
)
FOR 2879: ImmunoStroke: From immune cells to stroke recovery
(Spokesperson
Liesz, Arthur
)
ImmunoStroke: From Immune Cells to Stroke Recovery Linking functional immune profiles and ischemic lesion characteristics in human stroke
(Applicants
Klotz, Luisa
;
Thomalla, Götz
;
Tolosa, Eva
;
Wiendl, Heinz
)
Meningeal immune cell priming for stroke recovery
(Applicants
Benakis, Corinne
;
Meyer zu Hörste, Gerd
;
Minnerup, Jens
)
Research Training Groups
Current projects
GRK 2515: Chemical Biology of Ion Channels (Chembion)
(Spokesperson
Wünsch, Bernhard
)
NFDI technical and methodological consortia
Current projects
National Research Data Infrastructure for Immunology
(Spokesperson
Busse, Christian
)
