Universitätsklinikum Heidelberg
Medizinische Klinik, Innere Medizin III
Klinik für Kardiologie, Angiologie und Pulmologie
Address
Im Neuenheimer Feld 410
69120 Heidelberg
Deutschland
GERiT
This institution in GERiT
69120 Heidelberg
Projects
Research Grants
Current projects
Causal modelling and adaptive experimental design for single-cell perturbation screens
(Applicants
Mall, Moritz
;
Meder, Benjamin
;
Steinmetz, Ph.D., Lars
)
circtools - a bioinformatics toolbox for circular RNA analysis
(Applicant
Dieterich, Christoph
)
Cohort Modeling of the Human Atria for in silico Trials
(Applicant
Loewe, Axel
)
Deciphering RNA modification patterns along single molecules: Modification crosstalk suppressing innate immunity
(Applicants
Altmüller, Janine
;
Dieterich, Christoph
)
Deciphering the 5ꞌ cap epitranscriptome by nanopore sequencing via chemo-enzymatic modification (DeCapNanoChem)
(Applicants
Dieterich, Christoph
;
Rentmeister, Andrea
)
Immunotherapy in cardiovascular disease
(Applicant
Jarr, Kai-Uwe
)
m6A metabolism in cardiomyozytes
(Applicant
Völkers, Mirko
)
Molecular Characterization of Tripartite Motif-containing (TRIM) E3 Ubiquitin Ligases in the Heart
(Applicant
Rangrez, Ph.D., Ashraf
)
Role of Cand2 in cardiac pathophysiology
(Applicant
Völkers, Mirko
)
Role of gut dysbiosis and microbial metabolites in the pathogenesis and progression of heart failure
(Applicants
Frey, Norbert
;
Rangrez, Ph.D., Ashraf
)
The metabolically-induced epigenetic memory as a Regulator of myocardial stress response
(Applicant
Lehmann, Lorenz
)
The serine biosynthetic pathway as a novel therapeutic target for familial dilated cardiomyopathy.
(Applicant
Seeger, Timon
)
The transcription factor Zeb1 in the heart
(Applicant
Kmietczyk, Vivien
)
Transcriptional control of cardiac function and bioenergetics regulatory circuits by type I interferon signaling
(Applicants
Kumari, Manju
;
Rangrez, Ph.D., Ashraf
)
Completed projects
Bedeutung des neuen Sarkomerproteins Calsarcin-2 in der Pathogenese von Skelettmuskelerkankungen
(Applicant
Frey, Norbert
)
Bedeutung von microRNAs in der Regulation streßbedingter kardialer Apoptose
(Applicant
Frank, Derk
)
Bedeutung von Tetrahydrobiopterin für die endothelvermittelte Regulation koronarer Widerstandsgefäße bei Arteriosklerose
(Applicant
Tiefenbacher, Christiane
)
Cardiac myosin light chain 1 dependent regulatory mechanisms in dilated cardiomyopathy
(Applicant
Meder, Benjamin
)
Charakterisierung des neuen kardialen Sarkomerproteins Calsarcin-1 im "knock-out"-Modell der Maus in vivo
(Applicant
Frey, Norbert
)
Charakterisierung von Myomasp, einem neuen M-Band-Protein
(Applicant
Eden, Matthias
)
Computer-based Quantification of Reconstructive Mitral Valve Surgery
(Applicants
De Simone, Ph.D., Raffaele
;
Engelhardt, Sandy
)
Deciphering the functions of human exon junction complexes
(Applicants
Dieterich, Christoph
;
Gehring, Niels H.
)
Die Bedeutung von HMGB1 in der Pathogenese der Herzmuskelentzündung und der dilatativen Kardiomyopathie
(Applicant
Andrassy, Martin
)
Die Rolle der myokardialen Angiogenese bei adaptiver und pathologischer Myokardhypertrophie
(Applicants
Chorianopoulos, Emmanuel K.
;
Frey, Norbert
)
Einfluss des proinflammatorischen Transkriptionsfaktors Egr-1 auf die atherosklerotische Genexpression in vitro und in vivo
(Applicant
Bea, Florian
)
Einfluß reaktiver Sauerstoffverbindungen auf den zellulären Phänotyp
(Applicant
Kreuzer, Jörg
)
Endotheliale Vorläuferzellen bei Organtransplantation - Autologe und allogene T-Zell-Aktivierung, Immunmodulation und therapeutischer Einsatz zur Gefäßprotektion
(Applicant
Dengler, Thomas J.
)
Entwicklung eines neuen adenoviralen Vektorsystems zur Herzmuskel-spezifischen Angiogenese bei ischämischer Kardiomyopathie
(Applicant
Franz, Wolfgang-M.
)
Entwicklung eines neuen adenoviralen Vektorsystems zur Herzmuskel-spezifischen Angiogenese bei ischämischer Kardiomyopathie
(Applicant
Zimmermann, René
)
Evaluating the efficacy of a miR-10 therapy after myocardial infarction
(Applicant
Hassel, David
)
Frequency-modulated magnetoelectric sensor systems for the measurement of broadband, low-frequency biomagnetic fields
(Applicants
Frey, Norbert
;
Höft, Michael
;
Stephani, Ulrich
;
Wagner, Bernhard
)
From channel protein to body surface ECG: Investigating electrocardiographic effects of ion channel mutations using computational heart models
(Applicants
Ley, Sebastian
;
Scholz, Eberhard
;
Seemann, Gunnar
)
Funktionelle Untersuchungen zur Beteiligung von Komplement/Komplementrezeptoren in der Pathogenese der Myokarditis
(Applicant
Kaya, Ziya
)
Funktion und Fehlfunktion des Intermediärfilamentproteins Desmin in Kardiomyozyten
(Applicant
Bär, Harald
)
Funktion von Syntaxin-1 in der regulierten Exozytose
(Applicant
Gerber, Stefan Horst
)
Gentherapie supraventrikulärer Arrhythmien
(Applicant
Bauer, Alexander
)
Hereditary sick sinus syndrome – phenotypic spectrum, genetic basis, cellular dysfunction and implications for therapy
(Applicants
Schweizer, Patrick A.
;
Thomas, Dierk
)
Identifizierung der für die Induktion von Herzmuskelentzündung verantwortlichen Epitope des kardialen Troponins I und Toleranzinduktion als Therapieansatz
(Applicant
Kaya, Ziya
)
Influence of extracellular matrix on physiological cardiac hypertrophy
(Applicant
Konstandin, Mathias
)
Inhibition der kardialen Hypertrophie durch die dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1 A (DYRK1A)
(Applicant
Kuhn, Christian
)
Inhibition of Cardiac Hypertrophy by Modulation Calcineurin-dependent Signal Transduction
(Applicant
Frey, Norbert
)
Inhibition of monocyte production using siRNA against CD115 and M-CSF in autoimmune myocarditis
(Applicant
Leuschner, Florian
)
Inhibition of Wnt signaling in monocytes and its possible role for healing in acute myocardial infarction.
(Applicant
Leuschner, Florian
)
Inhibitors of Histone Deacetylases; evaluation and target identification of a cardioprotective combination therapy for cancer
(Applicant
Lehmann, Lorenz
)
Interleukin-10 mRNA-Transfektion von Makrophagen zur antiinflammatorischen Therapie - proof of principle am Myokarditis- Modell der Maus
(Applicants
Kaya, Ziya
;
Zimmermann, Oliver
)
Investigations on the structural and functional basis of desminopathy
(Applicant
Bär, Harald
)
Mechanisms of K2P3.1 K+ channel and action potential regulation in atrial fibrillation and heart failure - implications for personalized antiarrhythmic therapy
(Applicants
Schmidt, Constanze
;
Thomas, Dierk
)
MIEdeep - Medical Information Extraction for German Medical Texts using Deep Learning Methods
(Applicants
Dieterich, Christoph
;
Geis, Nicolas
)
Molecular analysis of the regulation of cardiac IK1 current by protein kinase A and protein kinase C
(Applicant
Zitron, Edgar
)
Molecular and therapeutic aspects of proteolytic machineries in immune cells for cardiac inflammation.
(Applicants
Beling, Antje
;
Kaya, Ziya
)
Molecular characterization of Myoscape, a novel L-type Calcium channel binding protein involved in cardiac Calcium cycling, contractility and pathological hypertrophy
(Applicant
Eden, Matthias
)
Molecular genetic features in benign meningiomas in recurrence and progression
(Applicant
Ludwig, Nicole
)
Molecular mechnisms and signaling underlying S100A1 function in diseased myocardium
(Applicant
Pleger, Sven T.
)
MR-Tomographie an Patienten mit Herzschrittmachern
(Applicants
Dössel, Olaf
;
Katus, Hugo Albert
)
Negative Regulatoren der linksventrikulären Hypertrophie in vivo
(Applicant
Hardt, Stefan
)
Pro-inflammatory interleukin-17A: a modulator of atherogenesis
(Applicant
Erbel, Christian
)
Regulation and maintenance of cardiac function by the microRNA, miR-19
(Applicant
Hassel, David
)
Regulation endothelialer Aquaporin-1 Kanäle durch Proteinkinase C und Glucose- Degradationsprodukte: Bedeutung für die Peritonealdialyse
(Applicant
Schwenger, Vedat
)
Regulation repolarizing potanium channels by protein kinases and the role of ß-adrenergic stimulation in arrhythmogenesis
(Applicant
Kiehn, Johann
)
Role of microRNA-582 in cardiac signal transduction, hypertrophy and heart failure
(Applicant
Frey, Norbert
)
Role of mRNA Modifications in Cardiac Remodeling
(Applicant
Völkers, Mirko
)
Role of regulatory B-cells in pathogenesis and progression of autoimmune myocarditis
(Applicants
Kaya, Ziya
;
Tretter, Ph.D., Theresa
)
Significance of differentially expressed microRNAs and their target proteins in the development of autoimmune myocarditis in mouse model and patients
(Applicants
Kaya, Ziya
;
Müller, Oliver J.
)
The relevance of the oncoprotein HIF-1 for targeted therapy of hepatocellular carcinoma
(Applicant
Cramer, Thorsten
)
The role of the glucose-sensitive G protein-coupled orphan receptor GPRC5B in atherogenesis
(Applicant
Hippe, Hans-Jörg
)
Untersuchungen zu den genetischen Ursachen verkalkender Myokardnekrosen
(Applicant
Ivandic, Boris Tomislav
)
Untersuchungen zur Induktion einer Autoimmunreaktion auf zirkulierendes kardiales Troponin nach Myokardinfarkt und ihre klinische Bedeutung
(Applicant
Kaya, Ziya
)
Untersuchungen zur Kopplung des kardialen Inward-Rectifier Kaliumkanals HIRK (Kir2.1) an Second-messenger Systeme, Proteinkinase C und alpha-adrenerge Rezeptoren
(Applicant
Karle, Christoph
)
Research Fellowships
Completed projects
Charakterisierung abnormer Kaliumströme in insuffizienten Herzen mittels rekombinanter adenoviraler Transfektion
(Applicant
Bauer, Alexander
)
Die Rolle von miR-138 im molekularen Patterning der atrioventrikulären-Region sowie in der Herzvorläuferzelldetermination während der Herzentwicklung in der Maus und im Zebrafisch
(Applicant
Hassel, David
)
Induction of specific mutations for dilated or hypertrophic cardiomyopathy in isogenic human induced pluripotent stem cells to model disease and to elucidate molecular and signaling pathways
(Applicant
Seeger, Timon
)
Influence of extracellular matrix components on cardiac progenitor cell-mediated myocardial regeneration
(Applicant
Konstandin, Mathias
)
Kardialer S100A1 Gentransfer: Analyse zur Wirksamkeit eines neuen Kandidatenproteins zur somatischen Gentherapie der Herzinsuffizienz
(Applicant
Most, Patrick
)
Modulating fatty acid metabolism in pathological cardiac hypertrophy
(Applicant
Ritterhoff, Julia
)
Molekulare Mechanismen der Myokardhypertrophie und Herzinsuffizienz. Rolle des kardialen Transkriptionsfaktors MEF2
(Applicant
Frey, Norbert
)
S100A1 promotes myocardial wound healing after infarction by regulating monocyte function
(Applicant
Rohde, David
)
S100A4: Evaluation eines neuen Kandidatenproteins für die Prävention kardialen Zelltods und Steigerung der Regenerationsfähigkeit im ischämischen Myokard
(Applicant
Völkers, Mirko
)
'Theranostic' Trojan Horse Approach For Atherosclerosis.
(Applicant
Jarr, Kai-Uwe
)
Research Units
Completed projects
Modulation of myocardial remodeling by Wnt-signaling
(Applicant
Hardt, Stefan
)
Role of CEFIP, a Novel Z-disc Protein, in Cardiac Hypertrophy and Cardiomyopathy
(Applicant
Frey, Norbert
)
Emmy Noether Independent Junior Research Groups
Completed projects
mTOR dependent growth control in the myocardium
(Applicant
Völkers, Mirko
)
Heisenberg Professorships
Completed projects
Immunocardiology
(Applicant
Leuschner, Florian
)
Heisenberg Grants
Current projects
Immunocardiology
(Applicant
Leuschner, Florian
)
mRNA metabolism and translational control in cardiomyocytes
(Applicant
Völkers, Mirko
)
Emmy Noether International Fellowships
Completed projects
Modulation der Zwei-Porendomänen-Kaliumkanäle KCNKO und KCNK2 durch bioaktive Phospholipide, freie Fettsäuren und mechanische Dehnungsreize
(Applicant
Thomas, Dierk
)
Priority Programmes
Completed projects
Circular RNAs: novel regulators of dendritic protein synthesis during mammalian synapse development
(Applicants
Dieterich, Christoph
;
Schratt, Ph.D., Gerhard Martin
)
Deciphering human nonsense-mediated mRNA decay (NMD)
(Applicants
Dieterich, Christoph
;
Gehring, Niels H.
)
Molecular mechanisms of m6A mRNA modification in Drosophila neurogenesis
(Applicants
Dieterich, Christoph
;
Roignant, Jean-Yves
)
Clinical Trials
Completed projects
BOne marrOw transfer to enhance ST-elevation infarct regeneration-2
(Applicant
Drexler, Helmut
)
Effect of platelet inhibition and / or Lipid lowering in non-ACS-patients with acute chest pain, and high-sensitivity troponin values above the 99th percentile (GRAY-ZONE)
(Applicant
Karakas, Mahir
)
Clinical Research Units
Current projects
KFO 329: Disease pathways in podocyte injury – from molecular mechanisms to individualized treatment options
(Spokesperson
Benzing, Thomas
)
Podocyte lncRNAs – a novel player in focal-segmental glomerulosclerosis
(Applicants
Dieterich, Christoph
;
Müller, Roman-Ulrich
)
Collaborative Research Centres
Current projects
Cardiocrine signaling as a regulator of cardiac homeostasis and fibrosis
(Project Head
Leuschner, Florian
)
Cell-specific activation of Wnt signaling in healing after myocardial infarction
(Project Head
Leuschner, Florian
)
Control of cardiac homeostasis and cardiocrine signaling by protein arginine methyltransferases
(Project Heads
Backs, Johannes
;
Dieterich, Christoph
)
Deciphering molecular circuits of cardiac remodeling and dysfunction via an integrative reverse approach
(Project Heads
Frey, Norbert
;
Saez-Rodriguez, Julio
)
Disease modeling
(Project Heads
Dewenter, Matthias
;
Seeger, Timon
)
Dysregulation of mRNA decay in MYBPC3 hypertrophic cardiomyopathy
(Project Heads
Seeger, Timon
;
Stoecklin, Georg
)
INFrastructure for Biobanking, Data Management and Bioinformatics
(Project Heads
Dieterich, Christoph
;
Saez-Rodriguez, Julio
;
Weis, Tanja
)
Magnetoelectric sensor systems for cardiologic applications
(Project Heads
Frey, Norbert
;
Schmidt, Gerhard
)
Role of ETV transcription factors in atrial cardiomyopathy
(Project Head
Schmidt, Constanze
)
STAR family function and interaction with RBM20 for intervening alternative splicing
(Project Head
Meder, Benjamin
)
Targeting autophagy in cardiac remodeling via FYCO1
(Project Head
Frey, Norbert
)
The role of unconventional RNA-Binding proteins in the failing heart
(Project Heads
Hentze, Matthias
;
Völkers, Mirko
)
Type 2 immunity in cardiac injury and fibrosis
(Project Head
Leuschner, Florian
)
Completed projects
Applying quantitative profiling and imaging methods to explore the proteolytic plasticity of protein N-termini and protein misfolding processest
(Project Heads
Doroudgar, Ph.D., Shirin
;
Knop, Michael
)
Atrial Fibrillation and Atrial Tissue Lesions: Dynamics of Functional and Structural Remodelling, and Their Reversibility
(Project Head
Schmidt, Constanze
)
Modellierung und Lokalisation magnetokardiographischer Quellen
(Project Heads
Frey, Norbert
;
Klinkenbusch, Ludger
;
Wieckhorst, Arne
)
WBP Fellowship
Completed projects
Prediction of clinical outcomes in patients with moderate aortic valve regurgitation using deep learning
(Applicant
Gomes Botelho Quintas, Bruna Filipa
)
CRC/Transregios
Current projects
SCI-MODOM – Integration and Management of RNA modification data
(Project Heads
Dieterich, Christoph
;
Hildebrandt, Andreas
)
The mechanistic and functional impact of RNA modifications on alternative splicing
(Project Heads
Dieterich, Christoph
;
König, Ph.D., Julian
;
Roignant, Jean-Yves
)
Research Training Groups
Current projects
GRK 2727: Innate Immune Checkpoints in Cancer and Tissue Damage (InCheck)
(Spokesperson
Cerwenka, Adelheid
)
