Charité Universitätsklinikum
Campus Virchow-Klinikum
Julius Wolff Institut für Biomechanik
und Muskuloskeletale Regeneration (CVK)
Address
Augustenburgerplatz 1
13353 Berlin
Deutschland
GERiT
This institution in GERiT
13353 Berlin
Projects
Research Grants
Current projects
Assessment of the in vivo dynamics of knee joint tissue deformations – A technological basis to identify and understand structural and compositional changes in early onset osteoarthritis after injury
(Applicants
Brisson, Ph.D., Nicholas
;
Krämer, Martin
)
Influence of uterotomy closure technique on uterine wall stability in subsequent pregnancies
(Applicants
Braun, Thorsten
;
Paping, Alexander
)
Laying the foundations towards understanding physiological kinematics after Total Knee Arthroplasty
(Applicants
Ehrig, Rainald
;
Moewis, Ph.D., Philippe
)
Morpho-functional Modelling for patientspecific planning in total hip arthroplasty
(Applicants
Damm, Philipp
;
Radermacher, Klaus
)
Scaffold-guided bone defect regeneration: Effect of chronological ageing
(Applicant
Poh, Ph.D., Su Ping Patrina
)
"The friction acting in vivo in the artificial hip joint - what are the tribologically relevant influencing parameters in vivo?"
(Applicants
Damm, Philipp
;
Kretzer, Jan Philippe
)
The Host Defense Peptide LL37 in the Treatment and Prevention of Osteoradionecrosis of the Jaws
(Applicant
Koerdt, Steffen
)
Timing matters - The impact of the circadian clock on fracture healing
(Applicant
Jahn, Denise
)
Towards mechanobiological optimized mandible reconstructions with a fibula free flap
(Applicants
Checa Esteban, Ph.D., Sara
;
Rendenbach, Carsten
)
Completed projects
Beanspruchungsgerechte Osteosyntheseplanung komplexer, gelenkinvolvierender Frakturen der proximalen Tibia
(Applicant
Duda, Georg
)
Belastung von Hüftendoprothesen
(Applicant
Bergmann, Georg
)
Belastung von Knieendoprothesen
(Applicant
Bergmann, Georg
)
Determination of the in vivo loads of the sheep spineIs the sheep a suitable model to study new treatment strategies for the intervertebral disc?
(Applicant
Schmidt, Hendrik
)
Development of instrumented shoulder implant for load measurements
(Applicant
Bergmann, Georg
)
Development of MR-based procedures and technologies for non-invasive in-vivo assessment of mechanical loading of tissues: Movement and straining of soft tissue structures using the knee joint as example system
(Applicants
Duda, Georg
;
Reichenbach, Jürgen R.
;
Zachow, Stefan
)
Druck und Kinematik im stabilen und instabilen Patellofemoralgelenk unter muskuloskeletaler Belastung
(Applicant
Duda, Georg
)
Endoscopic treatment of injuries of the anterior pelvic ring: biomechanical comparison of five different endoscopic stabilization techniques
(Applicant
Küper, Markus
)
Entwicklung und Testung eines biomechanischen Modells für das Schafsbein zur Reduzierung und Optimierung von Tierversuchen zur Frakturheilung
(Applicant
Claes, Lutz
)
Entwicklung und Testung eines biomechanischen Modells für das Schafsbein zur Reduzierung und Optimierung von Tierversuchen zur Frakturheilung
(Applicant
Duda, Georg
)
Immunologische Charakterisierung der initialen Phase des Frakturhämatoms beim Menschen
(Applicant
Buttgereit, Frank
)
Influence of biological factors on the mechanical regulation of tissue differentiation processes during large bone-defect healing.
(Applicant
Duda, Georg
)
Influence of the sagittal balance on the segmental load and the success of the surgical treatment of degenerative diseases of the spine
(Applicant
Putzier, Michael
)
Initiale Phase der Knochenheilung: Inflammation und Organisation
(Applicant
Perka, Carsten
)
In situ control of mesenchymal stem cell behavior using programmable biomaterials
(Applicant
Mehta, Manav
)
Interaction of biological and mechanical stimuli during bone defect healing: Identify the role of early inflammation as a key regulator of mechanically induced tissue regeneration
(Applicant
Duda, Georg
)
Investigation of the mechanical regulation of lumbar inter-corporeal spinal fusion
(Applicant
Schmidt, Hendrik
)
In vivo knee joint loading and kinematics – the interplay between movement and loading at the patello-femoral and tibio-femoral joints.
(Applicant
Trepczynski, Adam
)
In vivo Messung der Schultergelenksbelastung
(Applicant
Bergmann, Georg
)
Loading of the knee and hip joint during swimming and water gymnastics
(Applicant
Kutzner, Ines
)
Load measurement in patients using an instrumented vertebral body replacement
(Applicant
Rohlmann, Antonius
)
Messung der Belastung eines Wirbelkörperersatzes bei Patienten
(Applicant
Rohlmann, Antonius
)
Osteochondrale Defektheilung - Mechanobiologische und molekularbiologische Mechanismen der Regeneration
(Applicant
Duda, Georg
)
Quantifizierung des Einflusses von Gelenkersatz und Umstellungsosteotomien auf die muskuloskeletale Beanspruchung des Oberschenkels
(Applicant
Duda, Georg
)
Quantifizierung des Einflusses von Gelenkersatz und Umstellungsosteotomien auf die muskuloskeletale Beanspruchung des Oberschenkels
(Applicant
Claes, Lutz
)
Rechnerische Analyse des Einflusses bewegungserhaltender Implantate im LWS-Bereich auf das mechanische Verhalten der Wirbelsäule
(Applicant
Rohlmann, Antonius
)
Rechnerische Simulation von Operationsverfahren zur Stabilisierung der Lendenwirbelsäule
(Applicant
Rohlmann, Antonius
)
Regeneration of tissue interfaces: Biomaterial controlled morphogen gradients for tissue patterning in regeneration
(Applicant
Duda, Georg
)
Resolution of inflammation in tendon disease: how is the bursa involved?
(Applicant
Klatte-Schulz, Franka
)
Strukturmechanische Simulation von degenerativer Spondylolisthese und degenerativer Skoliose zur Ermittlung möglicher Entstehungsursachen
(Applicant
Rohlmann, Antonius
)
The structural and mechanical recovery of soft tissues define joint-level function after acute injury: The healing of Achilles tendon rupture as a model system
(Applicants
Agres, Alison
;
Guo, Jing
)
Towards understanding long-term cartilage degeneration: The role of passive joint laxity and active joint instability in pathological knee kinematics
(Applicants
Duda, Georg
;
Ehrig, Rainald
)
Clinical Research Units
Completed projects
Beanspruchungsgerechte Osteosyntheseplanung komplexer Frakturen und Umstellungen der Tibia
(Applicant
Duda, Georg
)
Die sezernierten Phosphatonine FGF23 und sFRP4 - ihre Bedeutung bei der osteogenen Differenzierung, im Phosphatstoffwechsel und ihr therapeutisches Potential für das Tissue Engineering
(Applicant
Jakob, Franz
)
Einfluss mechanischer und biologischer Stimulation auf Osteoklasten, Osteoblasten und deren Co-Kultur in vitro
(Applicant
Schmidmaier, Gerhard
)
Entwicklung eines Implantats zur telemetrischen Messung der Knochenbelastung beim Schaf
(Applicant
Bergmann, Georg
)
KFO 102: Biomechanics and Biology of Bone Healing: Individual, Load Adapted Osteosynthesis
(Spokesperson
Haas, Norbert P.
)
Korrelation von in vivo interfragmentärer Bewegung und Beanspruchung mit dem klinischen Heilungsergebnis
(Applicant
Raschke, Michael J.
)
Mittelung stark streuender Belastungsdaten
(Applicant
Bergmann, Georg
)
Muskuloskelettale Belastung und biologische Antwort im validierten Schafsmodell
(Applicant
Duda, Georg
)
Prognose der Frakturheilung anhand knochenspezifischer Parameter unter Berücksichtigung der mechanischen Rahmenbedingungen in vivo
(Applicant
Bail, Hermann Josef
)
Service Biomechanik und Histomorphometrie
(Applicant
Duda, Georg
)
Research Units
Current projects
Articulated, statistical 3D shape and bone density model of the human spine for research in clinical biomechanics as well as for individualized diagnosis and therapy planning in orthopaedics
(Applicant
Zachow, Stefan
)
Coordination Funds
(Applicant
Schmidt, Hendrik
)
Correlation between lumbar spinal performance and clinical outcomes after spine treatment in LBP patients
(Applicant
Arampatzis, Ph.D., Adamantios
)
Dynamics of posture, shape, and motion of asymptomatic subjects and LBP patients in daily life activities
(Applicants
Pumberger, Matthias
;
Schmidt, Hendrik
)
FOR 5177: The Dynamics of the Spine: Mechanics, Morphology and Motion towards a comprehensive Diagnosis of Low Back Pain
(Spokesperson
Schmidt, Hendrik
)
Influence of local tissue injuries, repair and degeneration on spinal Morphology, Mechanics and Motion in a large animal model
(Applicants
Checa Esteban, Ph.D., Sara
;
Reitmaier, Sandra
)
In vivo mechanical loading and tissue adaptation in vertebrae: Inflammation, pain and opioid effects
(Applicants
Celik, Ph.D., Melih Özgür
;
Duda, Georg
)
Musculoskeletal simulations towards a subject-specific spino-pelvic load transfer prediction
(Applicant
Schmidt, Hendrik
)
Completed projects
Coordination Funds
(Applicant
Duda, Georg
)
FOR 2165: Regeneration in Aged Individuals: Using Bone Healing as a Model System to Characterise Regeneration under Compromised Conditions
(Spokesperson
Duda, Georg
)
Mechano-dependency of early bone healing, angiogenesis, and their interplay across ages
(Applicants
Duda, Georg
;
Gerhardt, Holger
)
Nutrition, aging and marrow adipose tissue in bone maintenance and regeneration
(Applicants
Schmidt-Bleek, Katharina
;
Schulz, Tim J.
)
Physical activity and psychosocial characteristics of asymptomatic subjects and low back pain patients in real life
(Applicant
Fleig, Lena
)
Understand and reshape the impact of “aged” adaptive immunity and type 2 diabetes/obesity on fracture healing
(Applicants
Schmidt-Bleek, Katharina
;
Volk, Hans-Dieter
)
Collaborative Research Centres
Current projects
Bone marrow adipose tissue: Harnessing metabolic regulation to shape bone maintenance and regeneration
(Project Heads
Schmidt-Bleek, Katharina
;
Schulz, Tim J.
)
Central Administrative Project ‐ Central tasks of the Collaborative Research Centre
(Project Head
Duda, Georg
)
Decoding and harnessing the impact of immune‐experience on the spatio‐temporal cellular interaction networks underlying bone healing
(Project Heads
Haas, Simon
;
Schmidt-Bleek, Katharina
;
Volk, Hans-Dieter
)
From prediction to validation: Mechanical factors of impaired fracture healing in humans
(Project Heads
Trepczynski, Adam
;
Zachow, Stefan
)
Impact of the central nervous system on metabolic and immunological responses, particularly focusing on adrenergic signaling and circadian rhythm in bone and fracture following trauma
(Project Heads
Jahn, Denise
;
Pumberger, Matthias
;
Tsitsilonis, Ph.D., Serafeim
)
Mechano‐dependency of early bone healing, angiogenesis, and inflammation
(Project Heads
Duda, Georg
;
Gerhardt, Holger
)
SFB 1444: Directed Cellular Self-Organization to Advance Bone Regeneration
(Spokesperson
Duda, Georg
)
Spatiotemporal regulation of sprouting angiogenesis through combined mechanical and geometrical cues
(Project Heads
Checa, Sara
;
Petersen, Ansgar
)
Understand and shape bone regeneration by cellular metabolic adaptation in immune and stromal cells
(Project Heads
Duda, Georg
;
Sawitzki, Birgit
)
Completed projects
Analyses of in vivo data of loads in the human body
(Project Head
Bergmann, Georg
)
Biology of musculoskeletal regeneration and evaluation of guided tissue formation
(Project Heads
Bail, Hermann Josef
;
Lienau, Jasmin
)
Biomechanical characterisation of bone healing and regeneration in small and large animals
(Project Heads
Duda, Georg
;
Schell, Hanna
)
Hydrogels with spatial patterning of biophysical and biochemical properties to guide osteogenesis
(Project Heads
Cipitria, Ph.D., Amaia
;
Duda, Georg
)
Mechano-biology of bone healing and regeneration
(Project Heads
Duda, Georg
;
Weinkamer, Richard
)
Organisation and structural integration
(Project Heads
Duda, Georg
;
Haas, Norbert P.
)
SFB 760: Biomechanics and Biology of Musculoskeletal Regeneration - From Functional Assessment to Guided Tissue Formation
(Spokesperson
Duda, Georg
)
Priority Programmes
Completed projects
Efficient Uncertainty Modeling for Additively Manufactured Polymer Scaffolds in Bone Tissue Engineering
(Applicants
Dondl, Patrick
;
Neukamm, Stefan
)
Identification of Stresses in Heterogeneous Contact Models
(Applicants
Duda, Georg
;
Weiser, Martin
)
Workshops for Early Career Investigators
Completed projects
Vom lebenden Material lernen, technische Materialien für die Geweberegeneration und für medizinische Implantate entwickeln (Nachwuchsakademie Medizintechnik 2010)
(Applicant
Duda, Georg
)
Graduate Schools
Completed projects
GSC 203: Berlin-Brandenburg School for Regenerative Therapies (BSRT)
(Spokesperson
Duda, Georg
)
