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Mechano‐dependency of early bone healing, angiogenesis, and inflammation (P09)

Subject Area Medical Informatics and Medical Bioinformatics
Term since 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188
 
This project investigates how mechanical loading influences vascular proliferation and callus organization during early bone healing. We focus on cell interactions between pre-osteoblasts, endothelial cells, and immune cells, as well as the connections between fibronectin, collagen, and microvascular self-organization through YAP/TAZ. We will examine the dynamics between pericytes and endothelial cells, the effects of vimentin phosphorylation and YAP/TAZ signaling, and the influence of immunological experience versus vascular aging to gain new insights into the interplay of immune cells during angiogenesis in bone healing, as Basis for the development of novel therapeutic approaches.
DFG Programme Collaborative Research Centres
Applicant Institution shared FU Berlin and HU Berlin through:
Charité - Universitätsmedizin Berlin
 
 

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