From prediction to validation: Mechanical factors of impaired fracture healing in humans (P06)

• Subject Area: Medical Informatics and Medical Bioinformatics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188

This project will focus on quantifying patient-specific bone loading and finding ways to optimize the mechanical conditions at the fracture by means of fixation configuration, adapted rehabilitation, and gait modification. The project will link the CRC to human patients by employing retrospective data from the successfully completed BioBone study and validate the findings about the mechanical environment with prospective measurements. The project will also investigate the potential use of advanced imaging techniques (e.g., dynamic bi-planar fluoroscopy, EOS-system) for evaluating the specific mechanical environment in the clinical routine. This will enable a comprehensive improvement of fracture treatment by providing the mechanical prerequisite for the biological mechanism of healing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1444: Directed Cellular Self-Organization to Advance Bone Regeneration
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Adam Trepczynski; Dr. Stefan Zachow