Universität Leipzig
Institut für Biochemie
Arbeitsgruppe Biochemie und Bioorganische Chemie
Address
Brüderstraße 34
04103 Leipzig
Deutschland
GERiT
This institution in GERiT
04103 Leipzig
Projects
Research Grants
Current projects
Structure Elucidation of the Neuropeptide Y5 Receptor- Relevant in Food intake and Cancer
(Applicant
Beck-Sickinger, Annette G.
)
Completed projects
Constrained analogues of neuropeptides to identify the bioactive conformation at different receptors and develop subtype selective ligands
(Applicant
Beck-Sickinger, Annette G.
)
Dynamics of the molecular recognition of G-protein-coupled-receptor/ligand interaction: neuropeptide Y and interleukin 8
(Applicant
Beck-Sickinger, Annette G.
)
Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions
(Applicants
Beck-Sickinger, Annette G.
;
Schöneberg, Torsten
)
Identifizierung der Rezeptorinteraktion von RF-amid-Peptiden auf molekularer Ebene
(Applicant
Beck-Sickinger, Annette G.
)
Clinical Research Units
Completed projects
Atherobesity: Molekulare Mechanismen
(Applicant
Beck-Sickinger, Annette G.
)
Collaborative Research Centres
Current projects
Central Administration
(Project Head
Beck-Sickinger, Annette G.
)
Characterizing the molecular interactions between Y receptors and arrestin
(Project Heads
Beck-Sickinger, Annette G.
;
Huster, Daniel
)
Molecular mechanisms of allosteric modulators at Y-receptors
(Project Head
Beck-Sickinger, Annette G.
)
Peptide synthesis and membrane protein (GPCR) expression
(Project Heads
Beck-Sickinger, Annette G.
;
Scheerer, Patrick
)
SFB 1423: Structural Dynamics of GPCR Activation and Signaling
(Spokesperson
Beck-Sickinger, Annette G.
)
Completed projects
Development of modulators at the chemokine-like receptor to elucidate its role in obesity
(Project Heads
Beck-Sickinger, Annette G.
;
Meiler, Jens
)
Molecular Mechanisms of Action of Adipokines
(Project Head
Beck-Sickinger, Annette G.
)
On the role of protein loops in the biosynthesis and in the ligand-receptor interaction of the neuropeptide Y system
(Project Head
Beck-Sickinger, Annette G.
)
SFB 610: Variation in Protein Conformation: Cellbiological and Pathological Relevance
(Spokesperson
Beck-Sickinger, Annette G.
)
Targeted delivery of drugs into adipocytes by peptide-mediated shuttling in a new obesity mouse model
(Project Heads
Beck-Sickinger, Annette G.
;
Klöting-Blüher, Nora
)
Targeting of central peptide receptors via nasal ligand application to modulate food intake
(Project Heads
Bechmann, Ingo
;
Beck-Sickinger, Annette G.
;
Klöting-Blüher, Nora
;
Schulz, Angela
)
Zentrale Aufgaben des Sonderforschungsbereichs
(Project Head
Beck-Sickinger, Annette G.
)
Research Units
Completed projects
Markierung von Peptidhormonen mit Metallkomplexen für Tumordiagnostik und -therapie
(Applicants
Beck-Sickinger, Annette G.
;
Neundorf, Ines
)
CRC/Transregios
Completed projects
Chemical modification of proteins for the characterization of matrix-protein interactions
(Project Head
Beck-Sickinger, Annette G.
)
Integrated Research Training Group "Matrix Engineering"
(Project Heads
Beck-Sickinger, Annette G.
;
Scharnweber, Dieter
;
Werner, Carsten
)
Priority Programmes
Completed projects
Peptide-templated bioconjugation of proteins on and in live cells for studies of GPCR trafficking and crosstalk
(Applicants
Beck-Sickinger, Annette G.
;
Seitz, Oliver
)
Research Fellowships
Completed projects
Directed evolution of bacterial polysialyltransferases for structural studies and their application for enzymatic polysialylation of therapeutic proteins
(Applicant
Baumann, Lars
)
Major Research Instrumentation
Completed projects
Konfokales High-Content Imaging System
MALDI-ToF mass spectrometer
Research Training Groups
Completed projects
GRK 378: Mechanisms and Applications of Non-Conventional Oxidation Reactions
(Spokesperson
Hey-Hawkins, Evamarie
)
Graduate Schools
Completed projects
GSC 185: Leipzig School of Natural Sciences - Building with Molecules and Nano-objects (BuildMoNa)
(Spokesperson
Hey-Hawkins, Evamarie
)
