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Max-Planck-Institut für Biochemie (MPIB)

Address Am Klopferspitz 18
82152 Planegg
Deutschland

GERiT This institution in GERiT

82152 Planegg

Projects

Research Grants
- Completed projects
Research Fellowships
- Completed projects
  - Erstellen einer Knockout Maus als Modell für die X-gekoppelte lymphoproliferative Erkrankung und Analyse des SH2D1A Gens auf eine mögliche Tumorsuppressorfunktion an Non-Hodkin-Burkitt Tumor Zellinien
    (Applicant Brandau, Oliver )
Priority Programmes
- Completed projects
Research Units
- Current projects
  - FOR 2599: Tissue type 2 responses: Mechanisms of induction and regulation
    (Spokesperson Roers, Axel )
  - Regulation of type 2 immunity mediated at the level of macrophage polarization
    (Applicant Murray, Peter J. )
- Completed projects
  - Structural analysis of CRISPR/Cas assemblies
    (Applicant Conti, Elena )
Independent Junior Research Groups
- Current projects
  - DNA Origami-templated Silica nanostructures for applications in biomedicine and catalysis
    (Applicant Heuer-Jungemann, Amelie )
- Completed projects
  - Signaling Proteomics: Die Analyse von Signaltransduktionsnetzwerken tierischer und pflanzlicher Rezeptorkinasen mit Hilfe der Proteinmassenspektrometrie
    (Applicant Schulze, Waltraud )
Collaborative Research Centres
- Current projects
  - SFB 1064: Chromatin Dynamics
    (Spokesperson Becker, Peter Burkhard )
- Completed projects
  - Analysis of the cellular Function of FMRP, the Disease Gene Product of Fragile X Syndrome
    (Project Head Fischer, Utz )
  - a) Zentrale Proteinanalytik, b) Die Biosynthese von Hypusin und Hypusin-haltigen Dipeptiden
    (Project Head Lottspeich, Friedrich )
  - Chaperon-vermittelte Faltung von Zytoskelettproteinen
    (Project Heads Hartl, Franz-Ulrich ; Siegers, Katja )
  - Characterization of novel signaling molecules controlling integrin activation during atherogenesis
    (Project Head Moser, Markus )
  - Chromosome segregation: how to preserve genomic integrity during cell division?
    (Project Head Nigg, Erich A. )
  - Crystal structure Determination of Proteins Related to Alzheimer`s Disease
    (Project Heads Bode, Wolfram ; Than, Manuel E. )
  - DNA assemblies for structural analysis of guest molecules and plasmon-enhanced SERS
    (Project Heads Heuer-Jungemann, Amelie ; Liedl, Tim )
  - Dynamik der halobakteriellen Retinalproteine
    (Project Head Oesterhelt, Dieter )
  - Dynamik organization of the actin system in vivo and in vitro
    (Project Heads Baumeister, Wolfgang ; Gerisch, Günther )
  - Entwicklung neuer selektiver Inhibitoren für INtegrine und ihr Einsatz in der Krebstherapie
    (Project Heads Kessler, Horst ; Schmidt, Eva-Kathrin ; Schmitt, Manfred )
  - Functional Characterization of AML-associated Mutants of Nucleophosmin
    (Project Head Müller, Stefan )
  - Functional Relationship between the Actin- and Microtubule-Based Transport Systems
    (Project Heads Mizuno, Naoko ; Ökten, Zeynep )
  - Function of the Cdc48 segregase and its co-factors
    (Project Head Jentsch, Stefan )
  - Funktionalle Analyse des menschlichen Zentrosoms
    (Project Head Nigg, Erich A. )
  - Funktionelle Analyse der ß1 Integrin Signalübertragung via ILK-PINCH
    (Project Head Fässler, Reinhard )
  - Funktionseinheiten für Einzelmolekülmaschinen
    (Project Heads Gaub, Hermann E. ; Oesterhelt, Dieter )
  - HsiVU und die Proteasom assoziierten ATPasen
    (Project Heads Groll, Michael ; Huber, Robert )
  - Integration of mRNA export and transcription elongation
    (Project Head Conti, Elena )
  - Integrin-fibronectin interactions in atherosclerotic plaque formation
    (Project Head Fässler, Reinhard )
  - Kapazitives Gating rekombinanter Kalium- und Calciumkanäle auf Halbleiterchips
    (Project Head Fromherz, Peter )
  - Kraftmikroskopische Untersuchungen der Struktur und Dynamik nativer Retinalproteine im Millisekundenbereich
    (Project Head Fritz, Monika )
  - Kraftmikroskopische Untersuchungen von Struktur und Konformation nativer Motorproteine
    (Project Head Fritz, Monika )
  - Lichtinduzierte Konformationsübergänge in Modellpeptiden
    (Project Heads Moroder, Luis ; Renner, Christian )
  - Mechanics of in vivo actin networks
    (Project Head Wedlich-Söldner, Roland )
  - Mechanism of homology search during DNA double-strand break repair
    (Project Head Jentsch, Stefan )
  - Mechanisms of chaperonins and down-stream factors in assisted proetin folding and assembly
    (Project Heads Hartl, Franz-Ulrich ; Hayer-Hartl, Manajit )
  - Mechanisms of Force Transduction across Talin to Integrin-Ligand Complexes
    (Project Head Fässler, Reinhard )
  - Mechanisms of integrin activation - a process fundamental for the priming and transmigration of autoreactive T-cells in MS
    (Project Heads Brakebusch, Cord ; Fässler, Reinhard ; Moser, Markus )
  - Mechanisms of proteotoxicity in neurodegenerative Diseases
    (Project Head Hartl, Franz-Ulrich )
  - Mikrospektroskopie an Grenzflächen
    (Project Heads Hillenbrand, Rainer ; Keilmann, Fritz )
  - Molekulardiagnostische und funktionelle Untersuchungen zur Bedeutung von Phosphotyrosinphosphatasen für Wachstum und Metastasierung des Mammakarzinoms
    (Project Heads Ullrich, Axel ; Wallasch, Christian )
  - Neue Klassen und Varianten des GFPs
    (Project Head Budisa, Nediljko )
  - Photoinduzierbare Bindungen von Zelladhäsionsrezeptoren an peptidfunktionaliesierte Oberflächen
    (Project Heads Ehmoser, Eva-Kathrin ; Oesterhelt, Dieter )
  - Phytochrom
    (Project Head Gärtner, Wolfgang )
  - Proteinanalyse sowie Charakterisierung von niedermolekularen Inhaltsstoffen aus dem Milchsaft von Schlafmohn (Papaver somniferum)
    (Project Heads Lottspeich, Friedrich ; Zenk, Meinhart H. )
  - Proteinfaltungsmaschinen, untersucht mit AFM/SNOM
    (Project Head Guckenberger, Reinhard )
  - Protein sorting at the trans-Golgi network (TGN) and its impact on immune cell migration
    (Project Head von Blume, Ph.D., Julia )
  - Regulation of the DEAD-box RNA helicase Sub2 by TREX
    (Project Head Conti, Elena )
  - Role of integrin trafficking and stability for leukocyte migration
    (Project Heads Böttcher, Ralph Thomas ; Fässler, Reinhard )
  - SFB 413: Dynamics and regulation of cytoskeleton dependent motile activities
    (Spokesperson Schleicher, Michael )
  - SFB 533: Lichtinduzierte Dynamik von Biopolymeren
    (Spokesperson Scheer, Hugo )
  - SFB 563: Bioorganic functionnal systems on solids
    (Spokesperson Stutzmann, Martin )
  - SFB 571: Autoimmune Reactions: From Manifestations and Mechanisms to Therapy
    (Spokesperson Hohlfeld, Reinhard )
  - SFB 576: Facultative Microbial Pathogenesis and Innate Immunity
    (Spokesperson Holzmann, Bernhard )
  - SFB 594: Molecular Machines in Protein Folding and Protein Transport
    (Spokesperson Beckmann, Roland )
  - SFB 596: Molecular Mechanisms of Neurodegeneration
    (Spokesperson Haass, Christian )
  - SFB 646: Networks in Genome Expression and Maintenance
    (Spokespersons Beckmann, Roland ; Cramer, Patrick )
  - SFB 684: Molecular Mechnisms of Normal and Malignant Hematopoiesis
    (Spokespersons Bohlander, Stefan Klaus ; Hiddemann, Wolfgang )
  - SFB 863: Forces in Biomolecular Systems
    (Spokesperson Rief, Matthias )
  - SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
    (Spokesperson Walzog, Barbara )
  - SFB 1032: Nanoagents for Spatio-temporal Control of Molecular and Cellular Reactions
    (Spokesperson Rädler, Joachim )
  - SFB 1035: Control of Protein Function by Conformational Switching
    (Spokesperson Buchner, Johannes )
  - Soluble fibronectin and bacterial defence
    (Project Head Fässler, Reinhard )
  - Structure and function of the actin-binding protein coactosin
    (Project Head Gerisch, Günther )
  - Structure and funktion of VAT, the archaeal homologue of Cdc48 and p97
    (Project Heads Baumeister, Wolfgang ; Kessler, Horst ; Peters, Jürgen )
  - Strukturbasierendes Design, Synthese und enzymkinetische Charakterisierung von Proteinaseinhibitoren und Proteinasesubstraten
    (Project Head Moroder, Luis )
  - Strukturbasiertes Design und Synthese von Proteinase- Inhibitoren und -Substraten
    (Project Head Moroder, Luis )
  - Strukturelle Charakterisierung regulatorischer Proteine des Zytoskeletts
    (Project Head Huber, Robert )
  - Strukturelle Flexibilität von Phycobiliprotein-Komplexen
    (Project Heads Huber, Robert ; Reuter, Wolfgang )
  - Struktur- und Funktionsuntersuchungen membranständiger Chaperone immobilisiert auf Festkörperoberflächen
    (Project Heads Guckenberger, Reinhard ; Zeth, Kornelius )
  - The 20S Proteasome: Mechanisms of assembly and substrate translocation
    (Project Head Baumeister, Wolfgang )
  - The ubiquitin-editing enzyme A20 in B cell physiology and malignancy
    (Project Head Schmidt-Supprian, Marc )
  - Three-dimensional structural investigations of macromolecular complexes and cellular structures on solid substrates by cryo-electron tomography
    (Project Heads Baumeister, Wolfgang ; Plitzko, Jürgen M. )
  - Translational control of protein folding by elongation kinetics
    (Project Head Nedialkova, Danny )
  - Untersuchung der Molekularen Dynamik und Struktur von Phycoerythrocyanin (PEC) und des Grün-Fluoreszierenden Proteins (GFP) mittels Kernresonanz-Spektroskopie und Kristallographie
    (Project Head Holak, Tadeusz )
  - Untersuchung der Molekularen Dynamik und Struktur von Zytoskelett-Proteinen mittels Kernresonanz-Spektroskopie und Kristallographie
    (Project Head Holak, Tadeusz )
  - Zelladhäsionsprozesse an ECM-funktionalisierten Oberflächen
    (Project Heads Ehmoser, Eva-Kathrin ; Moroder, Luis ; Renner, Christian )
  - Zentrale Proteinanalytik
    (Project Head Lottspeich, Friedrich )
DIP Programme
- Completed projects
  - Chemical proteomics inside us: Using chemical tools to decipher coexistence between bacteria and humans
    (Applicants Mann, Matthias ; Meijler, Ph.D., Michael )
  - Structure and dynamics of integrin-mediated cell adhesion - from phenotype to molecular level
    (Applicants Fässler, Reinhard ; Medalia, Ohad )
Heisenberg Fellowships
- Completed projects
  - The Role of Roquin in Immune Cell Physiology and Pathology
    (Applicant Schmidt-Supprian, Marc )
CRC/Transregios
- Current projects
  - TRR 387: Functionalizing the Ubiquitin System against Cancer - UbiQancer
    (Spokesperson Bassermann, Florian )
  - TRR 392: Molecular evolution in prebiotic environments
    (Spokesperson Braun, Dieter )
- Completed projects
  - Engineering minimal cell walls for the emergence of shape in protocells
    (Project Heads Heuer-Jungemann, Amelie ; Mutschler, Hannes ; Schwille, Petra )
  - Evaluation of IKK2/ß Inhibition as targeted Therapy in B Cell Lymphomas and the Role of c-Rel Overexpression in B Cell Lymphomagenesis
    (Project Head Schmidt-Supprian, Marc )
  - Local immunomodulation by viral vectors and genetic modifications
    (Project Heads Bähr, Andrea ; Hinkel, Rabea ; Kupatt, Christian ; Michel, Sebastian ; Murray, Peter J. )
  - Molecular mechanisms of Superkiller-like helicases
    (Project Head Conti, Elena )
  - TRR 54: Growth and Survival, Plasticity and Cellular Interactivity of Lymphatic Malignancies
    (Spokesperson Dörken, Bernd )
  - TRR 127: Biology of Xenogeneic Cell and Organ Transplantation - From Bench to Bedside
    (Spokespersons Reichart, Bruno ; Wolf, Eckhard )
  - TRR 174: Spatiotemporal dynamics of bacterial cells
    (Spokesperson Thanbichler, Martin Rudolf )
  - TRR 235: Emergence of Life: exploring mechanisms with cross-disciplinary experiments
    (Spokesperson Braun, Dieter )
Research data and software
- Completed projects
  - Systembiologische Analysen des Krebsgenoms mit Hilfe deduktiver Datenbanken
    (Applicants Frommolt, Peter ; Lang, Ulrich ; Larsson, Nils-Göran )
Research Training Groups
- Completed projects
  - GRK 1721: Integrated Analysis of Macromolecular Complexes and Hybrid Methods in Genome Biology
    (Spokesperson Hopfner, Karl-Peter )
International Research Training Groups
- Completed projects
  - GRK 1563: Regulation and Evolution of Cellular Systems
    (Spokespersons Frishman, Dmitrij ; Zimmer, Ralf )
Clusters of Excellence
- Completed projects
  - EXC 4: Nanosystems Initiative Munich (NIM)
    (Spokespersons Bein, Thomas ; Feldmann, Jochen )
  - EXC 114: Munich Center for Integrated Protein Science (CIPSM)
    (Spokesperson Carell, Thomas )
  - EXC 1010: Munich Cluster for Systems Neurology (SyNergy)
    (Spokesperson Haass, Christian )
Graduate Schools
- Completed projects
  - GSC 1006: Graduate School of Quantitative Biosciences Munich (QBM)
    (Spokesperson Frey, Erwin )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2145: Munich Cluster for Systems Neurology (SyNergy)
    (Spokespersons Haass, Christian ; Misgeld, Thomas )

Subinstitutions

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