SFB 1690:  Disease Mechanisms and Functional Restoration of Sensory and Motor Systems

• Subject Area: Medicine ; Computer Science, Systems and Electrical Engineering ; Physics
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 528760423

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A01 - Audiogenetic Clinic Göttingen: Clinical, Genetic, and Functional Characterization of Novel Hearing Loss Genes (Project Heads Strenzke, Nicola ;  Wollnik, Bernd )
• A02 - Hair Cell CaV1.3 Channelopathies: Disease Mechanisms and Preclinical Development of Gene Therapeutic Approaches (Project Heads Pangrsic Vilfan, Tina ;  Sakata, Ph.D., Eri )
• A03 - Otoferlin-Related Auditory Synaptopathy: In Vitro Analysis of Disease Mechanisms (Project Heads Preobraschenski, Julia ;  Vona, Ph.D., Barbara )
• A04 - Otoferlin-Related Auditory Synaptopathy: Disease Mechanisms and Preclinical Development of Gene Therapeutic Approaches (Project Heads Kusch, Kathrin ;  Moser, Tobias )
• A05 - Investigating the Mechanisms of Age-Related Synaptopathy in the Mouse Utricle (Project Heads Rizzoli, Ph.D., Silvio-Olivier ;  Wichmann, Carolin )
• A06 - Pathomechanisms of Sensory Defects in the Eye During Autoimmune Gray and White Matter Disease (Project Heads Flügel, Alexander ;  Odoardi, Francesca )
• A07 - Optimizing Stimulation of Input-Deprived Networks to Restore and Maintain Their Function (Project Heads Neef, Andreas ;  Priesemann, Viola )
• B01 - Innovating Optogenetic Stimulation of the Rodent Auditory Pathway (Project Heads Mager, Ph.D., Thomas ;  Moser, Tobias )
• B02 - Inner Ear Modeling and Regeneration by Human Otic Organoids (Project Heads Wrobel, Christian ;  Zafeiriou, Ph.D., Maria Patapia )
• B03 - Designing the Optogenetic Control of Spiral Ganglion Neuron Populations for Maximal Audi-tory Information Flow (Project Head Wolf, Fred )
• B04 - Listening and Communicating with Optogenetic and Electrical Cochlear Implants in Marmo-sets (Project Head Jeschke, Marcus )
• B05 - Towards Optogenetic Restoration of Natural Retinal Activity (Project Head Gollisch, Tim )
• B06 - Investigating the Impact of Blindness-Induced Brain Plasticity on Optogenetic Vision Restora-tion (Project Head Macé, Emilie )
• B07 - Assessing Gene Therapeutic Microtubule Stabilization for Axon Restoration in the Injured Adult Spinal Cord (Project Head Bradke, Frank )
• B08 - Elucidating Inhibitory, Top-down Control of Motor Cortical Output for Advanced Bi-directional Neural Interfaces (Project Head Diester, Ilka )
• B09 - Multisensory Feedback for Learning to Control Brain-Computer Interfaces (Project Head Gail, Alexander )
• B10 - Bi-directional Neural Interfaces for Hand Grasping and Sensory Feedback (Project Head Scherberger, Hansjörg )
• B11 - Optogenetic Laryngeal Pacemaking (Project Heads Beutner, Dirk ;  Brügmann, Tobias )
• INF - Central Data Platform for Sensory and Motor Neuroscience (Project Heads Krefting, Dagmar ;  Wollnik, Bernd )
• Z01 - Central Task of the Collaborative Research Centre (Project Head Moser, Tobias )
• Z02 - Mouse, Marmoset, and Human Models of Diseases of Sensory and Motor Systems (Project Heads Behr, Rüdiger ;  Brose, Nils ;  Zafeiriou, Ph.D., Maria Patapia )
• Z03 - Developing µLED-Based Implantable Optogenetic Stimulators (Project Head Ruther, Patrick )

• Applicant Institution: Georg-August-Universität Göttingen
• Participating University: Albert-Ludwigs-Universität Freiburg
• Participating Institution: Max-Planck-Institut für Dynamik und Selbstorganisation ; Abteilung für Nichtlineare Dynamik; Deutsches Primatenzentrum GmbH (DPZ); Leibniz-Institut für Primatenforschung; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE); Max-Planck-Institut für Multidisziplinäre Naturwissenschaften
• Spokesperson: Professor Dr. Tobias Moser