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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Fachgruppe Molekulare Biomedizin
LIMES-Institut
Address
Carl-Troll-Straße 31
53115 Bonn
Deutschland
GERiT
This institution in GERiT
53115 Bonn
Projects
Research Grants
Current projects
Developmental functions of organelle contact sites in axonal morphogenesis
(Applicants
Bülow, Margret
;
Schmucker, Ph.D., Dietmar
)
Human immune responses to environmental changes - A dietary intervention study (ImmoDiet)
(Applicant
Bonaguro, Ph.D., Lorenzo
)
Identification of stage and cell specific cellular and gene regulatory networks involved in the progression of idiopathic pulmonary fibrosis
(Applicants
Schlitzer, Andreas
;
Skowasch, Dirk
)
OBSL1 in human papillomavirus infection
(Applicants
Florin, Luise
;
Lang, Thorsten
)
Structure, Function, and Optoribogenetics of RNA-Binding Blue-Light Receptors
(Applicants
Mayer, Günter
;
Möglich, Andreas
)
The role of the tetraspanin CD81 in the generation and maintenance of the neuronal extracellular matrix
(Applicants
Lang, Thorsten
;
Rizzoli, Ph.D., Silvio-Olivier
)
Uncovering the role of the small intracellular loop of tetraspanins by using CD9 as example
(Applicant
Lang, Thorsten
)
Viral particle associated tetraspanin assemblies
(Applicants
Florin, Luise
;
Lang, Thorsten
)
Completed projects
Ablation of horizontal cells and functional analyses of neurotransmitter receptors in horizontal cells of the retina
(Applicant
Willecke, Klaus
)
A modular approach for the identification of chemically modified aptamers for to date non-targetable molecules
(Applicant
Mayer, Günter
)
Aptamer-based inhibition of the chemokines CCL17 and CCL22 in allergic and inflammatory reactions
(Applicants
Förster, Irmgard
;
Mayer, Günter
)
Biological functions of cardiac connexins in mice
(Applicant
Willecke, Klaus
)
Clustering, processing and internalization of the amyloid precursor protein (APP) at the plasma membrane
(Applicant
Lang, Thorsten
)
Expression and function of connexins in conductive myocardium and smooth muscle cells of blood vessels and intestine
(Applicant
Willecke, Klaus
)
Functional characterisation of MyD88-induced signal transduction during allergic reactions and infections of the skin
(Applicant
Weighardt, Heike
)
Function of panglial gap junctional networks in mouse brain
(Applicants
Kettenmann, Helmut
;
Willecke, Klaus
)
Funktion cardiovaskulärer Connexine in der Maus
(Applicant
Willecke, Klaus
)
Funktion von Connexinen bei der Skelettmuskelbildung und Regeneration
(Applicant
Willecke, Klaus
)
Generation and functional analysis of mouse models for two dominant human genodermatoses: Hydrotic Ectodermal Dysplasia (HED) and Keratitis-Ichthyosis-Deafness (KID)
(Applicant
Willecke, Klaus
)
Lipid transport across the blood-brain barrier
(Applicant
Kuerschner, Lars
)
Molecular biology and function of gap junction channels in gland tissues
(Applicant
Willecke, Klaus
)
Rolle von Connexinen und CA2+-abhängigen K+-Kanälen bei der Regulation der mikrovaskulären Durchblutung
(Applicant
de Wit, Cor
)
Spatio-temporale Funktionsanalytik von Proteinen mit photoregulierbaren Aptameren während der Embryogenese von D. melanogaster
(Applicant
Mayer, Günter
)
Stoichiomeric biology and life cycle of the SNAREs
(Applicants
Lang, Thorsten
;
Rizzoli, Ph.D., Silvio-Olivier
)
Tetraspanin Enriched Microdomains - Web Formation and Function
(Applicant
Lang, Thorsten
)
Understanding the role of Gpr183 for the development and function of murine lung resident dendritic cells
(Applicant
Schlitzer, Andreas
)
Untersuchungen an elektrischen Synapsen und ihre Beeinflussung durch chemische Synapsen
(Applicant
Willecke, Klaus
)
Wechselwirkungen von adaptiver und angeborener Immunität bei der Immunantwort gegen polymikrobielle Sepsis
(Applicant
Weighardt, Heike
)
Research Units
Current projects
Cell type-specific regulation and function of the AHRR in skin inflammation and allergy
(Applicant
Weighardt, Heike
)
Deciphering Immune Cell Function in the Testis and Epididymis by Single-Cell Transcriptomics, Spatial Proteomics and Integrative Bioinformatics (Central Project Z1 of the FOR 5644 ‘INFINITE’)
(Applicants
Bartkuhn, Marek
;
Schlitzer, Andreas
;
Wilhelm, Jochen
)
FOR 5489: Understanding aryl hydrocarbon receptor (AHR) signalling in skin disorders
(Spokesperson
Krutmann, Jean
)
FOR 5547: Dissecting primary cilia dynamics in tissue organization and function
(Spokesperson
Gopalakrishnan, Ph.D., Jay
)
FOR 5644: The role of immune cells in the function of the normal and diseased testis and epididymis (‘INFINITE’)
(Spokesperson
Meinhardt, Andreas
)
Macrophage-epithelial cell interactions in the epididymis during homeostasis and inflammation
(Applicants
Meinhardt, Andreas
;
Schlitzer, Andreas
)
Primary cilia dynamics in adipose tissue development and homeostasis
(Applicants
Mass, Elvira
;
Wachten, Dagmar
)
Completed projects
Funktion von Connexinkanälen bei der Proliferation und Differenzierung von Keratinocyten in der Epidermis
(Applicant
Willecke, Klaus
)
Riboswitches as new antibacterial targets
(Applicant
Mayer, Günter
)
Priority Programmes
Completed projects
Molecular mechanisms of SNARE-patterning
(Applicant
Lang, Thorsten
)
Photoactivated RNA Binding in a Blue-Light Receptor Enables Optoribogenetics
(Applicants
Mayer, Günter
;
Möglich, Andreas
)
Independent Junior Research Groups
Completed projects
The impact of transcriptomic imprinting on the functional specialization of monocytes during health and disease
(Applicant
Schlitzer, Andreas
)
WBP Position
Current projects
Identifying signatures of chronic inflammation in human lymph node mononuclear phagocytes
(Applicant
Thomas, Ph.D., Jake
)
Collaborative Research Centres
Current projects
Developmental programming of hepatic tissue-resident macrophages by maternal high-fat diet
(Project Head
Mass, Elvira
)
Investigating the effect of obesity-induced metaflammation on dendritic cell development and function in mice and man
(Project Head
Schlitzer, Andreas
)
NaCl-dependent functional differentiation of dermal myeloid cell subpopulations
(Project Heads
Kolanus, Waldemar
;
Mass, Elvira
)
Completed projects
Aptamer Technologies
(Project Heads
Famulok, Michael
;
Kaupp, Ulrich Benjamin
;
Mayer, Günter
)
Cell biological characterization and function of different ceramides including sphingolipid derivatives in mice
(Project Head
Willecke, Klaus
)
Chemical Biology Platform - Development of small molecular and nucleic acid-based tools for local and chemical modulation of immune response
(Project Heads
Bajorath, Jürgen
;
Mayer, Günter
)
Flow Cytometry and Microscopy
(Project Heads
Endl, Elmar
;
Quast, Thomas
)
Funktion und Struktur cardiovaskulärer Connexinkanäle in der Maus
(Project Head
Willecke, Klaus
)
Membrane-proximal signaling events in migrating immune cells
(Project Heads
Kolanus, Waldemar
;
Quast, Thomas
)
Molecular mechanisms, dynamics and nano-anatomical aspects of membrane protein clustering
(Project Head
Lang, Thorsten
)
Molekularbiologie und Funktion von GAP Junction Kanälen in Drüsengeweben
(Project Heads
Ott, Thomas
;
Willecke, Klaus
)
Role of ceramide synthases in linking cellular lipid synthesis with body fat metabolism
(Project Heads
Bauer, Reinhard
;
Hoch, Michael
)
Rolle SNARE-Protein-regulierender Mechanismen in der Exocytose
(Project Heads
Jahn, Reinhard
;
Lang, Thorsten
)
Structure and function of immunological synapses and their role in peripheral immune tolerance
(Project Heads
Diehl, Ph.D., Linda
;
Lang, Thorsten
)
Untersuchungen zur Rolle der Connexin-Gene bei glialen und neuronalen Gehirnfunktionen
(Project Head
Willecke, Klaus
)
Untersuchungen zur Rolle der Connexingene und anderer cerebral ausgeprägter Gene bei Epilepsie
(Project Head
Willecke, Klaus
)
Research Fellowships
Completed projects
Entwicklung neuer Verfahren zur hochauflösenden Lokalisierung von Lipiden in Zellen
(Applicant
Kuerschner, Lars
)
CRC/Transregios
Completed projects
High resolution imaging of lipids
(Project Heads
Al-Amoudi, Ashraf
;
Kuerschner, Lars
)
Impact of carba-glucosamine on bacterial cell metabolism
(Project Head
Mayer, Günter
)
Organization and function of SNARE domains
(Project Head
Lang, Thorsten
)
Major Research Instrumentation
Completed projects
4-Laser Cell Sorter
Automatisierte Selektionsplattform
STED (Stimulated Emission Depletion) Mikroskop
Core Facilities
Completed projects
Center for Aptamer Research and Development
(Applicant
Mayer, Günter
)
Research Training Groups
Current projects
GRK 2873: Tools and Drugs of the Future - Innovative Methods and New Modalities in Medicinal Chemistry
(Spokesperson
Müller, Christa E.
)
Completed projects
GRK 246: Pathogenesis of Diseases of the Central Nervous System
(Spokesperson
Propping, Peter
)
GRK 1873: Pharmacology of 7TM-Receptors and Downstream Signalling Pathways
(Spokesperson
Pfeifer, Alexander
)
Clusters of Excellence (ExStra)
Current projects
EXC 2151: ImmunoSensation2 - the immune sensory system
(Spokespersons
Hartmann, Gunther
;
Kolanus, Waldemar
;
Latz, Eicke
;
Schultze, Joachim L.
)
Additional Information
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