Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum (CVK)
Institut für Medizinische Immunologie
Address
Augustenburger Platz 1
13353 Berlin
Deutschland
GERiT
This institution in GERiT
13353 Berlin
Projects
Research Units
Completed projects
FOR 299: Studying Biological Recognition Events with Optimized Molecular Libraries
(Spokesperson
Schneider-Mergener, Jens
)
FOR 2165: Regeneration in Aged Individuals: Using Bone Healing as a Model System to Characterise Regeneration under Compromised Conditions
(Spokesperson
Duda, Georg
)
Optimierte molekulare Bibliotheken zum Studium biologischer Erkennungsprozesse
(Applicant
Schneider-Mergener, Jens
)
Studium der Ligand-Erkennungsregion von CRH-Rezeptoren mit Peptid- und nichtpeptidischen Bibliotheken
(Applicant
Bienert, Michael
)
The WW-domain as a model system for the analysis of essential interactions in beta-sheets by incorporation of synthetic building blocks.
(Applicant
Volkmer, Rudolf
)
Understand and reshape the impact of “aged” adaptive immunity and type 2 diabetes/obesity on fracture healing
(Applicants
Schmidt-Bleek, Katharina
;
Volk, Hans-Dieter
)
Research Grants
Current projects
Paralysis of mucociliary clearance after cerebral ischemia by neurohumoral mechanisms
(Applicants
Kummer, Wolfgang
;
Meisel, Andreas
;
Meisel, Christian Alexander
)
Completed projects
Adoptiver Transfer gentechnisch modifizierter regulatorischer T-Zellen: Ein neuer Ansatz zur Toleranzinduktion bzw. Toleranzerhaltung
(Applicant
Ritter, Thomas
)
A label-free optical sensor system on silicon: Determining the thermodynamic and kinetic quantities of protein-ligand interactions
(Applicants
Petermann, Ph.D., Klaus
;
Rück-Braun, Karola
;
Volkmer, Rudolf
)
Allotransplantate-induced tolerance
(Applicant
Tullius, Ph.D., Stefan
)
Beneficial and unfavourable immune cells in fracture healing
(Applicant
Schell, Hanna
)
Characterization of Cardioprotection and Immunmodulation by FOXO3a as a Master Regulator of Adiponectin
(Applicants
Scheibenbogen, Carmen
;
Skurk, Carsten
)
Determination of immunological deviations in post-COVID-19 syndromes by single cell omics
(Applicants
Aschenbrenner, Anna
;
Sander, Leif Erik
;
Scheibenbogen, Carmen
;
Schultze, Joachim L.
)
Epigenetic alterations of TA-keratinocytes as underlying cause of hyperproliferation in psoriasis
(Applicant
Witte, Katrin
)
Funktionelle Analyse eines neuen Toleranz-assoziierten Gens mit Homologie zum hsp90-Ko-Chaperon p23
(Applicant
Grütz, Gerald
)
Immunodepression in aneurysmal subarachnoid hemorrhage patients
(Applicants
Martus, Peter
;
Meisel, Christian Alexander
;
Sarrafzadeh, Asita Simone
)
Immunologic and Genetic Analysis to Understand the Pathogenesis of Primary Selective IgM Immunodeficiency (sIgMID)
(Applicant
Stittrich, Anna B.
)
Immunologische Effekte von niedrig dosiertem Hydrokortison im septischen Schock
(Applicant
Keh, Didier
)
Mechanismen einer langanhaltenden Immundepression und erhöhten Suszeptibilität gegenüber Infektionen nach ischämischem Schlaganfall
(Applicant
Prass, Konstantin
)
Molekularer Mechanismus der TGF-ß induzierten Hemmung der zytokin-abhängigen IFN-gamma-Produktion
(Applicant
Grütz, Gerald
)
Preparation of a multicenter, randomized, open-label, blinded end point (PROBE) trial investigating the effects of immunemarker-guided preventive antibiotic therapy on the 3 months-outcome after acute ischemic stroke
(Applicant
Ulm, Lena
)
Proteomische Charakterisierung von krankheitsrelevanten PDZ Domänen und dessen gezielte intrazelluläre Interferenz mittels zell-penetrierender Peptide (CPPs).
(Applicant
Volkmer, Rudolf
)
Regulation of cytokine mRNA stability by IL-10
(Applicant
Grütz, Gerald
)
Untersuchung des therapeutischen Effektes von Hämoxygenase und dessen Metaboliten Kohlenmonoxid in Mausmodellen für Schwangerschaftskomplikationen
(Applicant
Zenclussen, Ana Claudia
)
Collaborative Research Centres
Current projects
Clarifying the epigenetic control mechanisms of the bone regenerative capacity in MSCs to tap new cell sources for adoptive cell therapy
(Project Heads
Geißler, Sven
;
Polansky-Biskup, Julia
;
Volk, Hans-Dieter
)
Decoding and harnessing the impact of immune‐experience on the spatio‐temporal cellular interaction networks underlying bone healing
(Project Heads
Haas, Simon
;
Schmidt-Bleek, Katharina
;
Volk, Hans-Dieter
)
Completed projects
Beneficial and unfavourable immune cells in fracture healing
(Project Heads
Schell, Hanna
;
Volk, Hans-Dieter
)
Central tasks of the Collaborative Research Centre
(Project Head
Volk, Hans-Dieter
)
Charakterisierung der Fitnesslandschaft von Aminosäuresequenzen durch eine theoriegestützte Untersuchung von Peptid-Proteinwechselwirkungen mitels molekularer Bibliotheken
(Project Heads
Frömmel, Cornelius
;
Schneider-Mergener, Jens
;
Volkmer, Rudolf
)
Coordination of Clinical Trials and Development of GMP procedures for cell-based therapeutic approaches
(Project Heads
Reinke, Petra
;
Volk, Hans-Dieter
)
Interaktionen zwischen Entzündungsprozessen im ZNS und dem peripheren Immunsystem: Untersuchungen zum Infektionsrisiko und -prävention bei einer ZNS-vermittelten systemischen Immunsuppression am Ratten-Modell
(Project Heads
Volk, Hans-Dieter
;
Woiciechowsky, Christian
)
Kartierung von Rezeptor-Ligand-Wechselwirkungen mittels Peptid-Bibliotheken
(Project Heads
Preissner, Robert
;
Volkmer, Rudolf
)
Mechanismen der "Immunparalyse" nach Trauma und Sepsis - Rolle der Hämoxygenase-1 (HO-1)
(Project Heads
Meisel, Christian Alexander
;
Volk, Hans-Dieter
)
Molekulare und zelluläre Mechanismen der Tumorimmunität durch Tumorzell-Transfektion mit Interleukin-Immunglobulin-Fusionsproteinen
(Project Heads
Bulfone-Paus, Silvia
;
Pohl, Thomas
)
Posttranskriptionelle Regulation von proinflammatorischen Zytokinen durch IL-10
(Project Head
Grütz, Gerald
)
Set-up and evaluation of am human adaptive immune system in cord blood stem cell-transplanted mice - a model for translational projects
(Project Heads
Sawitzki, Birgit
;
Volk, Hans-Dieter
)
SFB 650: Cellular Approaches for the Suppression of Unwanted Immune Reactions - From Bench to Bedside
(Spokesperson
Volk, Hans-Dieter
)
Tumortherapie mit rekombinanten Fusionsproteinen: IL-2-IgG und IL-15-IgG im Mausmodell
(Project Head
Pohl, Thomas
)
Untersuchungen zur Kommunikation zwischen Neural- und Immunzellen mittels akuter und chronischer intracerebro-ventrikulärer Applikation pro- und anti-inflammatorischer Zytokine im Tierversuch
(Project Heads
Volk, Hans-Dieter
;
Woiciechowsky, Christian
)
Research Fellowships
Completed projects
Identification of genetic risk variants for inflammatory bowel disease (IBD)
(Applicant
Stittrich, Anna B.
)
Major Research Instrumentation
Completed projects
Konfokales High Content Imaging System
Priority Programmes
Completed projects
Interactions between local and systemic immune response following controlled cortical impact injury in a rat model
(Applicant
Thomale, Ulrich
)
CRC/Transregios
Current projects
Role of microglia in chronic inflammation and long-term consequences after stroke
(Project Heads
Meisel, Andreas
;
Meisel, Christian Alexander
;
Safaiyan, Shima
)
Completed projects
Bedeutung von klonalen T-Zell-Expansionen und funktionellen T-Zellveränderungen bei Myokarditis und dilatativer Kardiomyopathie für die Pathogenese, Prognose und den Verlauf immunmodulatorischer Therapien
(Project Heads
Hummel, Michael
;
Noutsias, Michel
;
Volk, Hans-Dieter
)
Cardioprotective and Immunomodulatory Effects of Adiponectin in Inflammatory Cardiomyopathy
(Project Heads
Scheibenbogen, Carmen
;
Skurk, Carsten
)
Development of Novel RNA-Based and Gene Therapeutic Strategies in Cardiomyopathies
(Project Heads
Poller, Wolfgang
;
Scheibenbogen, Carmen
)
Einsatz molekularer Bibliotheken zur Identifizierung von T-Zellepitopen im Proteom von Myokarditis induzierenden Enteroviren am Beispiel des Coxsackievirus B3
(Project Heads
Kern, Florian
;
Volkmer, Rudolf
)
Importance of Toag-1 and Smarca3 for the Transcriptional Regulation of T Cells
(Project Heads
Sawitzki, Birgit
;
Volk, Hans-Dieter
)
Paralysis of pulmonary immunity after cerebral ischemia by parasympathetic nervous system
(Project Heads
Meisel, Andreas
;
Meisel, Christian Alexander
;
Volk, Hans-Dieter
)
Parvovirus B19 and Endothelial Regeneration
(Project Heads
Schmidt-Lucke, Caroline
;
Volk, Hans-Dieter
)
Role of CNS antigen-specific T cell responses for regeneration and functional outcome after stroke and impact of post-stroke infections
(Project Heads
Meisel, Andreas
;
Meisel, Christian Alexander
)
Use of peptide libraries to improve the generation of effector and helper T cells from immunosuppressed patients for adoptive T cell therapy - HCMV as a model
(Project Heads
Reinke, Petra
;
Volk, Hans-Dieter
)
Research Training Groups
Completed projects
GRK 80: Model Studies of Structures, Properties and Recognition of Biologically Relevant Molecules at Atomic Level
(Spokesperson
Höhne, Wolfgang
)
Graduate Schools
Completed projects
GSC 203: Berlin-Brandenburg School for Regenerative Therapies (BSRT)
(Spokesperson
Duda, Georg
)
