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Institution
Universitätsklinikum Ulm
Zentrum für Innere Medizin
Klinik für Innere Medizin III
Address
Albert-Einstein-Allee 23
89081 Ulm
Deutschland
GERiT
This institution in GERiT
89081 Ulm
Projects
Clinical Research Units
Completed projects
Core facility for molecular cytogenetics, genetic diagnostics and profiling
(Applicants
Bullinger, Lars
;
Langer, Christian
)
Inhibitor of Apoptosis Proteins (IAPs) als pathogenetisch relevante therapeutische Zielstruktur bei der chronischen lymphatischen Leukämie (CLL)
(Applicant
Stilgenbauer, Stephan
)
Radioaktive Arzneimittel zur Diagnostik und Therapie
(Applicant
Neumaier, Bernd
)
Radioimmuntherapie refraktärer akuter myeloischer Leukämien
(Applicant
Bunjes, Donald
)
Research Grants
Current projects
Multi-state modeling for the evaluation of prognostic and predictive biomarkers in acute myeloid leukemia
(Applicants
Benner, Axel
;
Beyersmann, Jan
;
Döhner, Hartmut
)
Transmission ecology and risk factors for cystic echinococcosis in sub-Saharan Africa
(Applicants
Kern, Peter
;
Mackenstedt, Ute
)
Completed projects
Array-basierte SNP-Analyse bei der akuten myeloischen Leukämie des Erwachsenen mit normalem Karyotyp zur Identifizierung genomischer Imbalancen und uniparentaler Disomien
(Applicant
Döhner, Konstanze
)
Cystic echinococcosis in sub-Saharan Africa Research Initiative (Epidemiology and clinical implications of the genetic diversity of Echinococcus spp. in eastern and southern Africa)
(Applicants
Kern, Peter
;
Romig, Thomas
)
Expressionsanalyse von Kandidatengenen bei der chronischen lymphatischen Leukämie (CLL) mittels quantitativer RT-PCR (RQ-PCR)
(Applicant
Stilgenbauer, Stephan
)
Extracellular vesicle RNA as systemic modulators of the tumor microenvironment in B cell lymphoma
(Applicants
Kuchenbauer, Florian
;
Mertens, Daniel
;
Seiffert, Martina
)
FLT3-ITD variants in AML - impact on disease biology and treatment outcome
(Applicants
Bullinger, Lars
;
Fischer, Thomas
)
Funktionelle Analyse rekurrenter Deletionen der chromosomalen Bande 3p14.1-p13 bei der akuten myeloischen Leukämie
(Applicant
Gaidzik, Verena
)
Hochauflösende "Single Nucleotide Polymorphism" (SNP) Microarray-Analyse bei der Chronischen Lymphatischen Leukämie (CLL): Identifizierung neuer Pathomechanismen und prognostischer Subgruppen
(Applicant
Stilgenbauer, Stephan
)
Identification and charakterization of the early developmental factor and homeobox gene VENTX2 in normal and malignant human hematopoiesis
(Applicant
Rawat, Ph.D., Vijay Pal Singh
)
Identifizierung pathogenetisch relevanter Sekundäraberrationen bei der Core Binding Factor Akuten Myeloischen Leukämie mit Hilfe array-basierter SNP-Analysen
(Applicant
Döhner, Konstanze
)
Immunogenität von mutations-spezifischen Peptidsequenzen bei der AML
(Applicant
Greiner, Jochen
)
Modulation of GVH/GVL by cytokines and induction of specific GVL by peptide vaccination in a mouse model
(Applicant
Schmitt, Michael
)
Molekulare und funktionelle Charakterisierung von Kandidatengenen in der Konsensusdeletionsregion 7q22-q31.1 bei myeloischen Leukämien
(Applicant
Döhner, Konstanze
)
Rolle des Rezeptors für Hyaluronsäure-vermittelte Motilität (RHAMM/CD168) bei der Proliferation myeloischer Blasten
(Applicant
Greiner, Jochen
)
Collaborative Research Centres
Completed projects
Central Tasks
(Project Head
Döhner, Hartmut
)
Characterization of the novel 'Human PBX1 Interacting Protein' (HPIP) and its role in normal and malignant hematopoiesis
(Project Head
Feuring-Buske, Michaela
)
Detailed characterization of genomic aberrations in pancreatic cancer and their role in prognosis and therapy
(Project Heads
Holzmann, Karlheinz
;
Schwänen, Carsten
)
Dissecting AML treatment response to FLT3 inhibitors by single-cell sequencin
(Project Heads
Döhner, Konstanze
;
Rippe, Karsten
)
Functional analysis of recurrent deletions of chromosomal band 3p14.1-p13 in acute myeloid leukemia
(Project Head
Gaidzik, Verena
)
Genomic instability, disease evolution and rational treatment development in CLL mouse models
(Project Heads
Jebaraj, Billy
;
Müller, Annika
;
Stilgenbauer, Stephan
)
Hyperthermie-assoziierte Expression von Hitzeschockproteinen, Protoonkogenen und Zytokin-Genen: Signaltransduktionswege und Identifizierung relevanter Transkriptionsfaktoren
(Project Head
Herrmann, Friedhelm
)
Mechanisms of CLL progression and Richter transformation in patients with CLL treated with agents targeting BTK and BCL2
(Project Heads
Döhner, Hartmut
;
Mertens, Daniel
;
Stilgenbauer, Stephan
)
Molecular and functional characterization of cooperating events in acute myeloid leukemia with NPM1 mutation
(Project Heads
Bullinger, Lars
;
Döhner, Konstanze
)
SFB 1074: Experimental Models and Clinical Translation in Leukemia
(Spokesperson
Döhner, Hartmut
)
The role of homeobox genes in erythroid leukemia
(Project Head
Feuring-Buske, Michaela
)
Major Research Instrumentation
Completed projects
Geräteeinheit für die Sequenzierung und Auftrennung genomischer Fragmente sowie für die quantitative PCR-Analyse
Priority Programmes
Completed projects
Genetic and epigenetic search for tumor suppressor genes on chromosome 7q in acute myeloid leukemia
(Applicants
Döhner, Hartmut
;
Plass, Christoph
)
Research Fellowships
Completed projects
Characterization of the immune microenvironment in chronic lymphocytic leukemia with regard to recurrent genomic aberrations and identification of mechanisms of resistance towards novel treatment strategies mediated by the immune microenvironment
(Applicant
Edelmann, Ph.D., Jennifer
)
Characterization of the molecular basis for combined epigenetic treatment and BCL2 inhibition in myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML)
(Applicant
Bohl, Stephan
)
The functional role of PPM1D in clonal hematopoiesis and therapy-related myeloid malignancies and its potential for therapeutic targeting
(Applicant
Agrawal, Mridul
)
Transcriptional and genetic profiling of clonal hematopoiesis at single-cell resolution
(Applicant
Jahn, Nikolaus
)
Clinical Trials
Completed projects
Prospective evaluation of residual disease in intensively treated patients with acute myeloid leukemia (AML) as surrogate endpoint for survival
(Applicant
Schlenk, Richard F.
)
Research Units
Current projects
FOR 2674: Aging-related epigenetic remodeling in acute myeloid leukemia
(Spokesperson
Lübbert, Ph.D., Michael
)
FOR 5659: TARGET-MPN: TARgetinG disease pErsisTence and progression of MyeloProliferative Neoplasms (MPN)
(Spokesperson
Heidel, Florian
)
Genetic Landscape of Acute Myeloid Leukemia (AML) in Older Patients
(Applicants
Bullinger, Lars
;
Döhner, Hartmut
;
Döhner, Konstanze
)
Longitudinal comprehensive transcriptome analyses to unravel disease persistence and evolution in MPN
(Applicants
Bullinger, Lars
;
Döhner, Konstanze
)
Graduate Schools
Completed projects
GSC 270: International Graduate School in Molecular Medicine Ulm
(Spokesperson
Kühl, Michael
)
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