Eberhard Karls Universität Tübingen
Universitätsklinik für Kinder- und Jugendmedizin
Abteilung I: Allgemeine Pädiatrie, Hämatologie/Onkologie
Address
Hoppe-Seyler-Straße 1
72076 Tübingen
Deutschland
GERiT
This institution in GERiT
72076 Tübingen
Projects
Research Grants
Completed projects
Die Analyse der Interaktion zwischen dem Transkriptionsfaktor LEF-1 und der Neutrophilen Elastase in der Granulopoese: die funktionelle Rolle von ELA2 Mutationen bei Patienten mit schwerer angeborener Netropenie.
(Applicant
Skokowa, Ph.D., Julia
)
Dissecting neutrophilic inflammation in cystic fibrosis lung disease: the role of chitinases
(Applicant
Hector, Andreas
)
G-CSF-dependent de-/acetylation of myeloid-specific transcription factors LEF 1 and C/EBPalpha in myeloid differentiation and leukemogenesis
(Applicant
Skokowa, Ph.D., Julia
)
Humanized NSG mouse model to study combinatorial leukemogenic effects of inherited ELANE and acquired CSF3R/RUNX1 mutations in congenital neutropenia
(Applicants
Skokowa, Ph.D., Julia
;
Welte, Karl
)
Hybrid Molecules From Benzylguanidine and Cytotoxic Drugs (Busulfan, Melphalan, Thiotepa) for Specific Therapy of Neuroblastoma
(Applicants
Brückner, Reinhard
;
Handgretinger, Ph.D., Rupert
)
Modified messenger RNA as a tool for ex vivo and in vivo gene correction
(Applicant
Kormann, Ph.D., Michael Sebastian Daniel
)
Role of monocytes and Th17 cells in the pathogenesis of graft-versus-host disease - influence of S100 proteins and Hsp90
(Applicant
Holzer, Ursula
)
Strukturanalysen des humanen Proteins HSP70 (Hitzeschockprotein 70 kDa) zur Untersuchung seiner Rolle in der spezifischen Immunabwehr.
(Applicant
Holzer, Ursula
)
The OX40-OX40L molecule system in leukemia: Expression, function and modulation of NK cell reactivity
(Applicant
Nuebling, Tina
)
Verstärkte CD4+ T-Zellaktivierung durch HSP70-gebundene Peptide: Mechanismen und klinische Relevanz bei Autoimmunerkrankungen
(Applicant
Holzer, Ursula
)
Emmy Noether Independent Junior Research Groups
Completed projects
Chemokine receptors on neutrophils: functionality and involvement in chronic lung disease
(Applicant
Hartl, Dominik
)
Collaborative Research Centres
Current projects
Support with preclinical animal models
(Project Heads
Dörr, Jan
;
Heeren-Hagemann, Anja
;
Schulte, Johannes Hubertus
)
Targeting rewired ALK/RAS/MAPK signaling in neuroblastoma
(Project Heads
Blüthgen, Nils
;
Schulte, Johannes Hubertus
)
Completed projects
Characterization and targeting of the chitinase-like innate immune protein YKL-40
(Project Head
Hartl, Dominik
)
Einfluss von Hitzeschockproteinen auf die Präsentation antigener Peptide und die Pathogense von Arthritis
(Project Head
Holzer, Ursula
)
G-CSF-vermittelte Signaltransduktion in myeloischen Zellen von Patienten mit schwerer kongenitaler Neutropenie im Vergleich zu gesunden Kontrollpersonen
(Project Head
Welte, Karl
)
Integrated Research Training Group "Immunotherapy"
(Project Heads
Frick, Julia-Stefanie
;
Hartl, Dominik
)
NK-cell and gamma/delta T-cell mediated immunotherapy of minimal residual disease after haploidentical stem cell transplantation in pediatric patients with B-lineage acute lymphoblastic leukemia
(Project Heads
Handgretinger, Ph.D., Rupert
;
Lang, Peter
)
Preclinical evaluation of the anti-histone/interleukin-12 fusion protein in the humanized mouse model for the treatment of childhood sarcomas
(Project Head
Handgretinger, Ph.D., Rupert
)
Rekonstitution und Modulation des NK-Zellsystems nach allogener Transplantation mit hochangereicherten Stammzellen
(Project Head
Lang, Peter
)
SFB 566: Cytokine Receptors and Cytokine-Dependent Signal Paths as Therapeutic Target Structures
(Spokesperson
Welte, Karl
)
Stammzell-Stroma-Interaktion: Rolle von Stromazellen in der Expansion hämatopoetisher Stamm- und Progenitorzellen
(Project Head
Welte, Karl
)
The role of TPO and MPL in congenital disorders of hematpoiesis
(Project Heads
Ballmaier, Matthias
;
Welte, Karl
)
Zentrale Aufgaben
(Project Head
Welte, Karl
)
Research Fellowships
Completed projects
Der Einfluss der sauren Säuger-Chitinase auf die Chemokinantwort des Asthma bronchiale
(Applicant
Hartl, Dominik
)
Molekulare Mechanismen der TH1/TH2-Differenzierung und ihre Bedeutung bei Autoimmunerkrankungen
(Applicant
Holzer, Ursula
)
Clinical Research Units
Completed projects
Etablierung eines human-murinen NOD/SCID/ycnull-Transplantationsmodells zur Evaluierung der antileukämischen Aktivität von NK Zellen
(Applicant
André, Maya Caroline
)
Genetik der kongenitalen Neutropenie
(Applicant
Klein, Christoph
)
KFO 110: Stem Cell Transplantation and Immunmodulation - Development of Molecular Therapeutic Strategies in Pediatrics
(Spokesperson
Welte, Karl
)
Untersuchungen zur Bedeutung der Neutrophilen Elastase bei kogenitalen Neutropenien
(Applicant
Beger, Carmela
)
Untersuchungen zur Bedeutung der Neutrophilen Elastase bei kongenitalen Neutropenien
(Applicant
Beger, Carmela
)
Major Research Instrumentation
Completed projects
Zellananalyse- und Sortiersystem
CRC/Transregios
Current projects
Microbe and host RNA-mediated immune activation in the skin
(Project Heads
Dalpke, Alexander
;
Eigenbrod, Tatjana
;
Hartl, Dominik
;
Weber, Ph.D., Alexander
)
Clinical Trials
Current projects
FRONTLINE AND RELAPSED RHABDOMYOSARCOMA: FAR-RMS
(Applicant
Sparber-Sauer, Monika
)
Research Training Groups
Current projects
GRK 2424: Computational Methods for Oncology: Towards Personalized Therapies in Cancer
(Spokesperson
Blüthgen, Nils
)
Clusters of Excellence (ExStra)
Current projects
EXC 2180: Image-Guided and Functionally Instructed Tumor Therapies (iFIT)
(Spokespersons
Pichler, Bernd
;
Rammensee, Hans-Georg
;
Walz, Juliane
;
Zender, Lars
)
