Universitätsklinikum Heidelberg
Medizinische Klinik, Innere Medizin V
Klinik für Hämatologie, Onkologie und Rheumatologie
Address
Im Neuenheimer Feld 410
69120 Heidelberg
Deutschland
GERiT
This institution in GERiT
69120 Heidelberg
Projects
Research Fellowships
Completed projects
Funktionelle Untersuchungen zur Beteiligung der src-Tyrosinkinase blk an B-Zell-Entwicklung und Signaltransduktion
(Applicant
Tretter, Ph.D., Theresa
)
The influence of the sympathetic nervous system on leukemic cells in vitro and in vivo
(Applicant
Buss, Eike Christian
)
Research Grants
Current projects
Hematopoietic Stem and Progenitor Cells with Elevated Central Carbon Metabolism Drive the Aging Process in Human Bone Marrow
(Applicants
Ho, Anthony D.
;
Raffel, Simon
)
Signaling properties of driver mutations in clonal hematopoiesis of indeterminate potential (CHIP) as targets for diagnostics and therapeutic intervention
(Applicant
Müller-Tidow, Carsten
)
Targeting phospholipid metabolism of chemotherapy-resistant leukemic stem cells
(Applicant
Raffel, Simon
)
Completed projects
Antibody-based BCMA targeted theranostics of multiple myeloma
(Applicants
Hose, Dirk
;
Pietzsch, Jens
;
Seckinger, Anja
)
Apoptotic cell-derived membrane microparticles: molecular characterization, immunmodulatory activity and their role in the pathogenesis of systemic lupus erythematosus
(Applicants
Lorenz, Hanns-Martin
;
Schiller, Martin
)
Asymmetrische Zellteilung als Parameter für Selbsterneuerung hämatopoetischer Stammzellen
(Applicant
Ho, Anthony D.
)
Bedeutung der CD40 Signaltransduktion in epithelialen und mesenchymalen Tumoren
(Applicant
Leo, Eugen
)
Chemokines of the CXCR3L family and their receptor in sclerodermatous chronic GVHD
(Applicants
Kumar, Rajiv
;
Luft, Ph.D., Thomas
)
Consequences of supernumerary centrioles in STIL-transgenic mice
(Applicant
Krämer, Alwin
)
Die Bedeutung altersabhängiger genomweiter DNA-Methylierungsmuster bei der Akuten Myeloischen Leukämie / Kennwort: Biologie der AML im Alter
(Applicant
Müller-Tidow, Carsten
)
Die Bedeutung des Proteinase-aktivierten Rezeptors 1 (PAR1) für die Hämatopoese und Pathogenese der akuten myeloischen Leukämie
(Applicant
Tickenbrock, Lara
)
Die Bedeutung von INCA1 als Zellzyklusregulator und Tumorsuppressor bei der Akuten Myeloischen Leukämie / Kennwort: INCA1 bei AML
(Applicant
Müller-Tidow, Carsten
)
Differenzierung immunologischer Effektorzellen durch extra- und intrazelluläre Modulation der Stärke und der Persistenz aktivierender Reize
(Applicant
Luft, Ph.D., Thomas
)
Entstehung und molekulare Struktur apoptotischer Blebs und ihre Bedeutung in der Pathogenese von Autoimmunität im Menschen
(Applicant
Lorenz, Hanns-Martin
)
Genomics and epigenomics approaches to characterize novel therapy targets in Ewing sarcoma
(Applicant
Müller-Tidow, Carsten
)
Identifikation und Charakterisierung zentrosomaler Cluster-Inhibitoren zur Induktion multipolarer Mitosen in Tumorzellen
(Applicant
Krämer, Alwin
)
Mechanisms of DNMT3A-mutation induced sensitization for 5-Azacytidine in AML
(Applicant
Müller-Tidow, Carsten
)
Metabolic processes in rheumatoid arthritis CD8+T cells: exploring their diagnostic value and potential as therapeutic targets
(Applicant
Souto-Carneiro, Ph.D., Margarida
)
Pathomechanisms inducing aberrant self-renewal and chemoresistance in GPR56high DNMT3A, NPM1, and FLT3-ITD triple mutated acute myeloid leukemia.
(Applicant
Pabst, Caroline
)
Repurposing doxycycline in the treatment of cardiac AL amyloidosis
(Applicant
Schönland, Stefan
)
Role of regulatory B-cells in pathogenesis and progression of autoimmune myocarditis
(Applicants
Kaya, Ziya
;
Tretter, Ph.D., Theresa
)
Small non-coding RNAs in lung cancer metastasis
(Applicants
Bäumer, Sebastian
;
Müller-Tidow, Carsten
)
The functional role of snoRNAs in NPM1 wildtype and mutant AML
(Applicant
Zhou, Ph.D., Fengbiao
)
The interaction of mesenchymal stromal cells and activated B cells in the context of fibrosis-associated autoimmune diseases, under special consideration of systemic sclerosis and CREST syndrome
(Applicant
Tretter, Ph.D., Theresa
)
The relevance of EZH2 dependent Stemness mechanisms for Therapy Response and Resistance in Acute Myeloid Leukemia
(Applicant
Müller-Tidow, Carsten
)
The role of receptor tyrosine kinases in the metastatic process of early stage non-small cell lung cancer
(Applicant
Müller-Tidow, Carsten
)
The role of the organspecific cyclin A1 gene in hemotopoiesis and pathogeneses acute myeloid leukemia
(Applicant
Müller-Tidow, Carsten
)
The role of the RNA binding protein RBM4 on leukemic stem cell activity in acute myeloid leukemia.
(Applicant
Pabst, Caroline
)
Untersuchung der Bedeutung von freien HLA Schwerketten für die Immunantwort beim Multiplen Myelom
(Applicants
Beckhove, Philipp
;
Witzens-Harig, Mathias
)
Wechselwirkung hämatopoetischer Stammzellen und ihrer Nischen: Zell-Zell Kontakte, Chemotaxis und Regulation von Selbsterneuerung versus Differenzierung
(Applicant
Ho, Anthony D.
)
Heisenberg Fellowships
Completed projects
Chromatin-Modifikation durch chromosomale Translokation in der Pathogenese der Akuten Myeloischen Leukämie
(Applicant
Müller-Tidow, Carsten
)
Innere Medizin
(Applicant
Krämer, Alwin
)
Clinical Trials
Completed projects
Phase-III study on the value of allogeneic stem cell transplantation in poor-risk chronic lymphocytic leukemia (GCLLSG/GCTSG CLL-X2 trial)
(Applicant
Dreger, Peter
)
Research Units
Completed projects
Adhesion GPCR signaling in hematopoietic stem and progenitor cells
(Applicant
Pabst, Caroline
)
FOR 2149: Elucidation of Adhesion-GPCR Signalling
(Spokesperson
Langenhan, Tobias
)
FOR 2969: Mechanisms of antibody light chain misfolding in systemic AL amyloidosis
(Spokesperson
Fändrich, Marcus
)
Sequence diversity of the light chains in two clinical variants of AL amyloidosis
(Applicants
Huhn, Stefanie
;
Schönland, Stefan
)
Variation of the AL protein primary structure in two clinical variants of AL amyloidosis
(Applicants
Haupt, Christian
;
Hegenbart, Ute
)
Emmy Noether Independent Junior Research Groups
Current projects
Metabolic Vulnerabilities of Acute Myeloid Leukemia Stem Cells
(Applicant
Raffel, Simon
)
Collaborative Research Centres
Completed projects
Charakterisierung der intrazellulären, CD45- oder Apoptose-assoziierten Signalkaskaden in ruhenden oder aktivierten Lymphozyten von Normalspendern oder Patienten mit systemischen Lupus erythematodes (SLE)
(Project Head
Lorenz, Hanns-Martin
)
Flow cytometry core unit
(Project Heads
Eckstein, Volker
;
Müller-Tidow, Carsten
)
Identification and functional analysis of barrier-breaking genes in myeloid cells
(Project Head
Müller-Tidow, Carsten
)
Molekulare Mechanismen der myelo-monozytären Differenzierung und der Monozytenfunktion: Rolle des Wnt-Signalwegs
(Project Head
Müller-Tidow, Carsten
)
SFB 873: Maintenance and Differentiation of Stem Cells in Development und Disease
(Spokespersons
Ho, Anthony D.
;
Lohmann, Jan
)
Major Research Instrumentation
Completed projects
Analytical 5 laser flow cytometer
Zellanalyse und Hochgeschwindigkeitssortiersystem
WBP Fellowship
Current projects
Simultaneous interrogation of genetic evolution and immune evasion of multiple myeloma using blood biopsy in patients treated with CAR-T cells.
(Applicant
Blocka, Joanna
)
Completed projects
Exploring the potential to restore cellular homeostasis in clonal hematopoiesis and immunity
(Applicant
Friedrich, Mirco
)
Knockout of CD96/TIGIT to enhance functionality of chimeric antigen receptor (CAR)-T cells
(Applicant
Korell, Felix
)
CRC/Transregios
Completed projects
Bone destruction in multiple myeloma: pathogenesis and model as basis for therapeutic targeting of bone substance defects by etiology-based bone substitute material
(Project Heads
Goldschmidt, Hartmut
;
Hose, Dirk
)
Cellular differences in sensitivity against drug releasing bone substitute materials within physiological and pathological bone remodeling
(Project Heads
Burhenne, Jürgen
;
Seckinger, Anja
;
Weiß, Johanna
)
Functionalized hydrogels presenting simultaneously β1-integrin selective ligands and bone morphogenic protein 6 to stimulate osteoblast function and induce myeloma cell apoptosis
(Project Heads
Cavalcanti-Adam, Elisabetta Ada
;
Seckinger, Anja
)
Quantitative studies of metabolism (F-18-deoxyglucose) and bone metabolism (F-18-fluoride) with dynamic positron emission tomography-computed tomography (dPET-CT)
(Project Heads
Dimitrakopoulou-Strauss, Antonia
;
Goldschmidt, Hartmut
;
Strauss, Ludwig Georg
)
The influence of bone substitute biomaterial on angiogenesis applied at bone defects caused by benign and malignant diseases
(Project Heads
Möhler, Thomas
;
Schwartz-Albiez, Reinhard
;
Willhauck-Fleckenstein, Martina
)
Priority Programmes
Completed projects
Functional evaluation of DNA methylation-controlled leukemia stem cell genes
(Applicants
Andrade-Navarro, Ph.D., Miguel
;
Rosenbauer, Frank
)
Plasticity Potential and Asymmetric Divisions of Hematopoietic Stem Cells
(Applicant
Ho, Anthony D.
)
The significance of DNA Methyltransferase inhibition and DNA Methylation for therapy response in Acute Myeloid Leukemia
(Applicant
Müller-Tidow, Carsten
)
