Ludwig-Maximilians-Universität München
Walther-Straub-Institut für Pharmakologie und Toxikologie
Address
Goethestraße 33
80336 München
Deutschland
GERiT
This institution in GERiT
80336 München
Projects
Priority Programmes
Completed projects
Heterotrimere G-Proteine olfaktorischer Signaltransduktionskaskaden
(Applicant
Boekhoff, Ph.D., Ingrid
)
Molekulare Grundlagen der selektiven Interaktion zwischen heterotrimeren GTPasen und den Rezeptoren für Gonadotropin- und Thyrotropin-Releasing-Hormon
(Applicant
Gudermann, Thomas
)
Perzeption von Pheromonen bei Säugern: Rezeptoren und Transduktionsmechanismen im Vomeronasalorgan
(Applicant
Boekhoff, Ph.D., Ingrid
)
Perzeption von Pheromonen bei Säugern: Rezeptoren und Transduktionsmechanismen im Vomeronasal Organ
(Applicant
Boekhoff, Ph.D., Ingrid
)
Emmy Noether International Fellowships
Completed projects
Entwicklung Subtyp-selektiver alpha-Conuspeptide als pharmakologische Werkzeuge zur Subtyp-Differenzierung neuronaler Acetylcholin-Rezeptoren
(Applicant
Nicke, Annette
)
Research Grants
Current projects
Deciphering new components of Ca2+-signaling in endolysosomes
(Applicant
Grimm, Christian Michael
)
Endolysosomal cation channels as novel targets for cancer therapy
(Applicants
Bartel, Karin
;
Grimm, Christian Michael
)
Role of two-pore channels in the astroglial Mechanosensitivity controlling water balance
(Applicant
Grimm, Christian Michael
)
The cardiac role of Piezo1
(Applicants
Deußen, Andreas
;
Mederos y Schnitzler, Michael
)
The role of the Transient Receptor Potential (TRP) channels in virus-induced lung fibrosis
(Applicant
Adler, Heiko
)
Completed projects
Cytomegalovirus-based vaccine vectors - the role of cytomegalovirus gH/gL/chemokine glycoprotein complexes in the vector-induced immune response
(Applicant
Adler, Barbara
)
Die Rolle von "transient receptor potential (TRP)"-Kanälen bei der Hypoxie-induzierten pulmonalen Hypertonie und beim vaskulären Gefäßumbau
(Applicant
Dietrich, Alexander
)
Infektion von Mäusen mit murinem Gammaherpesvirus-68(MHV-68) als Tiermodell zur Untersuchung der Rolle einzelner Gammaherpesvirus-Gene
(Applicant
Adler, Heiko
)
Investigation of the role of TRPML channel family and two-pore channel family members in intracellular fusion processes and the cation homeostasis of endolysosomal vesicles
(Applicant
Grimm, Christian Michael
)
Mechanics of receptor/g-protein-medicated growth of small cell lung carcinoma.
(Applicant
Gudermann, Thomas
)
Mechanismen der Gq/11- und G12/13- abhängigen Wachstumsregulation im kleinzelligen Bronchialkarzinom
(Applicants
Aigner, Achim
;
Gudermann, Thomas
)
Mechanisms of activation of lysosomal two-pore channel TPC2, a potential novel target for the treatment of lysosomal storage disorders and neurodegenerative diseases
(Applicant
Grimm, Christian Michael
)
Metabolism of the alkaloid myosmine
(Applicant
Zwickenpflug, Wolfgang
)
Molecular basis of TRPC4 and TRPC5 channel activation
(Applicant
Storch, Ursula
)
Molecular interaction between the voltage-dependent anion channel 2 and its agonist efsevin
(Applicant
Schredelseker, Ph.D., Johann
)
Physiological and pathophysiological role of the kinase-coupled ion channel TRPM6
(Applicant
Chubanov, Ph.D., Vladimir
)
Regulation and function of diacylglycerol-activated cation channels of the TRP family
(Applicant
Gudermann, Thomas
)
Regulation and function of P2X7 receptors in the central nervous system under physiological and pathophysiological conditions
(Applicant
Nicke, Annette
)
Rolle der humanen "sensory neuron-specific G protein-coupled receptors" bei der Nozizeption
(Applicant
Breit, Andreas
)
The acrosome reaction in sperm: A special type of regulated exocytosis
(Applicant
Boekhoff, Ph.D., Ingrid
)
Untersuchung der Assemblierung und Subtypcharakterisierung von Liganden-gesteuerten Ionenkanälen
(Applicant
Nicke, Annette
)
Untersuchungen über den Metabolismus des Alkaloids Myosmin
(Applicant
Zwickenpflug, Wolfgang
)
Untersuchungen zur DNA-Adduktbildung des Alkaloids Myosmin
(Applicant
Zwickenpflug, Wolfgang
)
Untersuchungen zur Funktion von Fibroblasten unter Belastung mit Zahnrestaurationsmaterialien und in Kombination mit Antioxidanzien sowie Untersuchungen zum Metabolismus von Zahnrestaurationsmaterialien in vitro
(Applicant
Walther, Udo
)
Research Units
Completed projects
Generation of transgenic mice to investigate the expression patterns, protein interactions and physiological functions of P2X4, P2X6 and P2X7 receptors
(Applicant
Nicke, Annette
)
Molekulare Mechanismen der myogenen Vasokonstriktion
(Applicants
Gudermann, Thomas
;
Mederos y Schnitzler, Michael
)
The P2X receptor binding domain: structure, conformational changes and coupling to the ion channel
(Applicant
Nicke, Annette
)
Heisenberg Fellowships
Completed projects
P2X-Rezeptoren - von der molekularen Struktur zur physiologischen Funktion
(Applicant
Nicke, Annette
)
Collaborative Research Centres
Current projects
Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels
(Project Heads
Freichel, Marc
;
Grimm, Christian Michael
)
Biochemical and functional analysis of P2X7 signaling
(Project Head
Nicke, Annette
)
Completed projects
Composition, cellular targeting and regulation of protein kinase-linked cation channel complexes of the TRPM family
(Project Heads
Gudermann, Thomas
;
Schlingmann, Karl Peter
;
Waldegger, Siegfried
)
Multiple Kopplung primär Gs-gekoppelter heptahelikaler Rezeptoren
(Project Head
Gudermann, Thomas
)
Physiologische Relevanz der multiplen G-Protein-Kopplung von Glykoproteinhormon-Rezeptoren
(Project Head
Gudermann, Thomas
)
Rezeptor-G-Protein-stimuliertes Wachstum des kleinzelligen Bronchialkarzinoms
(Project Heads
Gudermann, Thomas
;
Schultz, Günter
)
Rezeptor/G-Protein-vermitteltes Wachsstum des kleinzelligen Bronchialkarzinoms
(Project Heads
Gudermann, Thomas
;
Schultz, Günter
)
Major Research Instrumentation
Completed projects
Konfokalmikroskop für subzelluläres live-cell imaging
TIRF-FRET-FRAP-Calcium-Imaging Mikroskop
CRC/Transregios
Current projects
Administration / Guests / Travel / Gender Equality
(Project Head
Gudermann, Thomas
)
Endolysosomal cation channels in synucleo- and tauopathies
(Project Head
Grimm, Christian Michael
)
Identification and functional characterisation of genetic contributors to primary aldosteronism
(Project Heads
Beuschlein, Felix
;
Gudermann, Thomas
;
Reincke, Martin
;
Schneider, Holger
)
Investigating the mechanisms and dynamics of TRPC channel activation with pharmacological high-precision tools
(Project Heads
Konrad, David
;
Storch, Ursula
)
Role of kinase-coupled TRP channels in mineral homeostasis of the brain
(Project Heads
Chubanov, Ph.D., Vladimir
;
Gudermann, Thomas
)
Role of TRP channels in barrier function and pathological remodeling of the respiratory system
(Project Head
Dietrich, Alexander
)
Role of TRP channels in the systemic regulation of energy and glucose metabolism
(Project Heads
Khajavi, Noushafarin
;
Müller, Timo
;
Tschöp, Matthias
)
The kinase-coupled TRPM7 channel as a regulator of immune system homeostasis
(Project Head
Zierler, Susanna
)
TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
(Spokesperson
Gudermann, Thomas
)
Completed projects
Growth regulation of small cell lung cancer cells by neuropeptides
(Project Heads
Aigner, Achim
;
Gudermann, Thomas
)
WBP Fellowship
Completed projects
Deciphering structural bases of TRP channel inhibition as foundations for the design of new drugs
(Applicant
Neuberger, Arthur
)
WBP Return Grant
Completed projects
Rückkehrstipendium
(Applicant
Neuberger, Arthur
)
Research Training Groups
Current projects
GRK 2338: Targets in Toxicology - Deciphering Therapeutic Targets in Lung Toxicology
(Spokesperson
Gudermann, Thomas
)
Completed projects
GRK 533: Cell-Cell Interaction in Reproduction
(Spokesperson
Hinsch, Elvira
)
