Goethe-Universität Frankfurt am Main
Universitätsklinikum
Zentrum für Molekulare Medizin
Institut für Kardiovaskuläre Regeneration
Address
Theodor-Stern-Kai 7
60596 Frankfurt am Main
Deutschland
GERiT
This institution in GERiT
60596 Frankfurt am Main
Projects
Research Grants
Current projects
Inflammation-driven Diseases Program (INDEEP): inflammatory response as driver for human diseases and target for therapy
(Applicant
Ullrich, Evelyn
)
Mechanistic and functional assessment of the ageing cardiac lym-phatic system
(Applicant
Wagner, Julian
)
Completed projects
An integrative epigenomic approach to discover small RNA mediated regulatory programs in Paramecium tetraurelia
(Applicants
Schulz, Marcel
;
Simon, Martin
)
Endothelzelldysfunktion in der Atherosklerose - Untersuchungen zum Wirkmechanismus der Schubspannung
(Applicant
Dimmeler, Stefanie
)
Regulation of endothelial progenitor cells
(Applicant
Dimmeler, Stefanie
)
Significance of differentially expressed microRNAs and their target proteins in the development of autoimmune myocarditis in mouse model and patients
(Applicants
Kaya, Ziya
;
Müller, Oliver J.
)
Research Units
Current projects
FOR 5643: Clonal hematopoiesis: Pathomechanisms and clinical consequences in the heart and blood
(Spokesperson
Rieger, Michael
)
Interaction of clonal hematopoiesis-driver mutations with heart failure (Project A1)
(Applicants
Dimmeler, Stefanie
;
Zeiher, Andreas Michael
)
In vitro CHIP modelling for therapeutics discovery and mechanistic dissection (project A4)
(Applicant
Krishnan, Ph.D., Jaya
)
Mechanisms of aortic valve calcification driven by clonal hematopoiesis mutations (Project A2)
(Applicants
Abplanalp, Ph.D., Wesley
;
Mas-Peiro, Silvia
)
Completed projects
Molecular mechanisms underlying apoptosis and differentiation of circulating progenitor cells
(Applicant
Dimmeler, Stefanie
)
Zentrale Aufgaben
(Applicant
Dimmeler, Stefanie
)
Priority Programmes
Completed projects
In vitro transdifferentiation of human endothelial progenitor cells into cardiac myocytes: determination of the underlying mechanisms
(Applicant
Dimmeler, Stefanie
)
Collaborative Research Centres
Current projects
Bioinformatics
(Project Head
Schulz, Marcel
)
Damage-induced dynamics of the stromal compartment
(Project Head
de Luxan Garcia, Guillermo
)
Endothelial plasticity and damage control
(Project Head
Dimmeler, Stefanie
)
Reparative functions of endothelial cells in the aging heart
(Project Heads
Dimmeler, Stefanie
;
Wagner, Julian
)
Single Cell Technologies
(Project Head
Abplanalp, Ph.D., Wesley
)
Completed projects
Bedeutung der S-nitrosylierung von Proteinen bei der Apoptose von Endothelzellen: Charakterisierung der Denitrosylierung
(Project Heads
Dimmeler, Stefanie
;
Rössig, Lothar
)
Cell type-specific and stress-modulated microRNA target regulation
(Project Head
Dimmeler, Stefanie
)
Fibroblast dynamics to mitigate tissue damage
(Project Heads
Cattaneo, Paola
;
Guimarães Camboa, Nuno
)
Integrated Research Training Unit "Vascular Biology and Medicine"
(Project Head
Dimmeler, Stefanie
)
Long non-coding RNAs as regulators of endothelial cell function
(Project Head
Boon, Reinier
)
Regulation der Mobilisierung von Stamm/Progenitorzellen durch NO
(Project Heads
Aicher, Alexandra
;
Dimmeler, Stefanie
)
Regulation of vascular repair and remodelling by non-coding RNAs
(Project Heads
Dimmeler, Stefanie
;
Fichtlscherer, Stephan
;
Vasa-Nicotera, Mariuca
)
Role of JmjC domain-containing proteins in endothelial cell signaling and repair
(Project Head
Dimmeler, Stefanie
)
CRC/Transregios
Current projects
Bioinformatic analysis platform
(Project Heads
Gagneur, Julien
;
Schulz, Marcel
)
LncRNA control of cardiac inflammation
(Project Heads
Cremer, Sebastian
;
Dimmeler, Stefanie
;
Jaé, Nicolas
)
Localisation-dependent function of lncRNAs in cardiovascular disease: from mechanism to phenotype
(Project Head
Dumbovic, Gabrijela
)
Long non-coding RNAs in vascular ageing, remodeling, and abdominal aortic aneurysms
(Project Heads
Boon, Reinier
;
Mägdefessel, Lars
)
Completed projects
Elucidating protein-RNA interactions in circRNA biogenesis and function
(Project Heads
Dimmeler, Stefanie
;
Zarnack, Katharina
)
RNA regulatory mechanisms in cardiac metabolism
(Project Head
Krishnan, Ph.D., Jaya
)
Role of flow-induced microRNAs in vessel maturation
(Project Head
Dimmeler, Stefanie
)
Role of integrin activity regulation for endothelial cell adhesion, migration and angiogenesis
(Project Heads
Chavakis, Emmanouil
;
Dimmeler, Stefanie
)
Research Training Groups
Completed projects
GRK 1172: Research, Development and Safety of Biologicals
(Spokesperson
Pfeilschifter, Josef M.
)
Clusters of Excellence
Completed projects
EXC 115: Macromolecular Complexes
(Spokespersons
Dötsch, Volker
;
Schwalbe, Harald
)
EXC 147: Cardio-Pulmonary System
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
;
Zeiher, Andreas Michael
)
Clusters of Excellence (ExStra)
Current projects
EXC 2026: Cardio-Pulmonary Institute (CPI)
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
)
