Medizinische Hochschule Hannover
Zentrum Innere Medizin
Klinik für Gastroenterologie, Hepatologie und Endokrinologie
Address
Carl-Neuberg-Straße 1
30625 Hannover
Deutschland
GERiT
This institution in GERiT
30625 Hannover
Projects
Research Grants
Current projects
AAV-based gene replacement therapy in a murine model of Hereditary Spastic Paraplegia Type 5 (SPG5)
(Applicants
Hauser, Stefan
;
Ott, Michael
;
Schöls, Ludger
)
Immunopathogenesis of hepatitis D virus infection
(Applicants
Kefalakes, Helenie
;
Xu, Ph.D., Chengjian
)
MicroRNA-mediated modulation of metabolic pathways as a therapeutic principle in hepatocellular carcinoma.
(Applicant
Balakrishnan, Ph.D., Asha
)
Optimizing molecular and immunotherapies for the treatment of cholangiocarinoma
(Applicant
Vogel, Arndt
)
RNA-induced reprogramming of liver cells
(Applicant
Sharma, Ph.D., Amar Deep
)
Selective elimination of immunosuppressive cell populations and modulation of microenvironment for improvement of T cell infiltration of the pancreatic ductal adenocarcinoma
(Applicant
Ostroumov, Ph.D., Dmitrij
)
Targeting of liver tumors by viroimmunotherapy and molecular retargeting of virus-neutralizing antibodies
(Applicant
Kühnel, Florian
)
TCR-agnostic identification of tumor-specific CD8 T cells
(Applicants
Wedemeyer, Heiner
;
Woller, Norman
)
Therapeutic effects and mechanisms of selective TNF-receptor-1 inhibition in non-alcoholic fatty liver disease
(Applicant
Bantel, Heike
)
The role of DAMPs in the activation of cancer-associated fibroblasts in primary and secondary liver cancer
(Applicant
Mederacke, Ingmar
)
The role of MHC class II epitopes in spontaneous and therapeutic immune responses targeting liver cancer
(Applicant
Wirth, Thomas
)
The tumor microenvironment in cholangiocarcinoma - factors and phenotypes
(Applicant
Saborowski, Anna Lena
)
Completed projects
Analyse der Migration von CD8 positiven Memory T-Zellen nach wiederholter Antigenstimulation
(Applicant
Wirth, Thomas
)
Analysis of tumormutanome-specific T-cell responses
(Applicant
Woller, Norman
)
Applicability, efficacy and safety of targeted vehicle mediated in vivo base editing in a mouse model of hereditary hemochromatosis type I
(Applicant
Ott, Michael
)
Aufbau und Stabilisierung eines für die Tumorzellmigration notwendigen pH-Nanomilieus an der Zelloberfläche
(Applicant
Stock, Christian Martin
)
Bedeutung der Glycosaminoglykanketten kleiner Leuzin-reicher Proteoglykane in der Wundheilung
(Applicant
Seidler, Daniela G.
)
Bedeutung des Transkriptionsfaktors Nrf-2 für die Hämochromatose und die alkoholische Lebererkrankungen
(Applicant
Vogel, Arndt
)
Cellular mechanisms of intestinal bicarbonate transport: Molecular regulation and physiological function of the apical Cl'/HCOs" exchanger SLC26A6
(Applicant
Seidler, Ursula
)
Characterization of molecular mechanisms controlling phagocytosis of precancerous hepatocytes by macrophages and phagocytosis escape of hepatocellular carcinomas
(Applicant
Wirth, Thomas
)
Characterization of rDNA transcriptional activity in pre-implantation bovine embryos
(Applicant
Niemann, Heiner
)
Charakterisierung des Entwicklungspotentials fetaler somatischer Stammzellen (FSSCs) bei der Maus
(Applicant
Niemann, Heiner
)
Context-specific role of FGF21 in chronic liver diseases and hepatocarcinogenesis.
(Applicant
Vogel, Arndt
)
Derivation and characterization of pluripotent porcine cells
(Applicant
Niemann, Heiner
)
Die Bedeutung des Transkriptionsfaktors NF-kB für die Steroidresistenz bei chronisch entzündlichen Darmerkrankungen
(Applicant
Bantel, Heike
)
Die Bedeutung von TRAIL in der HCV-vermittelten Leberschädigung und Interferon-Resistenz
(Applicant
Bantel, Heike
)
Effects of meiosis-activating sterol on rRNA gene transcription and the developmental potential of preimplantation porcine embryos
(Applicant
Niemann, Heiner
)
Experimentelle Modulation der Telomerase-Aktivität in bovinen Embryonen
(Applicant
Niemann, Heiner
)
Functional characterization of candidate driver genes in pancreatic neoplasia development and maintenance using GEMM-ESC technology
(Applicant
Saborowski, Michael
)
Identification and characterization of a potential Biomarker and Modulator for HCC development derived from cancer type-specific long noncoding (Lnc) RNAs.
(Applicant
Tran, Ph.D., Doan Duy
)
Identification and functional characterization of cancer cell-derived, stroma-modulating factors in cholangiocarcinoma
(Applicant
Saborowski, Anna Lena
)
Impact of hetereologous immunity and CD8 T-cell cross-reactivity on the immunopathogenesis of acute HCV infection
(Applicant
Cornberg, Markus
)
Influence of check-point inhibitors on virus-specific T cell receptor repertoires
(Applicant
Kraft, Anke
)
Investigations of the tumor microenvironment of resectable transgenic hepatobiliary tumors after neoadjuvant therapy with gemcitabine and oncolytic virus
(Applicant
Kühnel, Florian
)
In vivo RNAi screen to identify new inhibitory targets in tumour-specific T lymphocytes during liver cancer development
(Applicant
Yevsa, Ph.D., Tetyana
)
Microsphere-based glypican-3 specific immunotherapy of hepatocellular carcinoma
(Applicant
Wirth, Thomas
)
Molekulare Ursachen der Defektregulation der intestinalen Salzresorption bei Mukoviszidose und sekretorischer Diarrhöe
(Applicant
Seidler, Ursula
)
New treatment options in autoimmune hepatitis
(Applicant
Hardtke-Wolenski, Matthias
)
p53-abhängige Virusreplikation im transgenen HCC Maus Mosaik Modell zur Aktivierung von chimären T Zellen
(Applicants
Kühnel, Florian
;
Sauer, Martin
)
Physiologische Funktion und Regulation der SLC26a7 und SLC27a9 in der Magenschleimhaut
(Applicant
Seidler, Ursula
)
rDNA genome re-programming in intergeneric somatic cell nuclear transfer embryos
(Applicant
Niemann, Heiner
)
Regulation des Na+/HCO3--Kotransporters (NBC) in der Kolonschleimhaut: Pathophysiologische Bedeutung der basolateralen Anionenaufnahmemechanismen bei Mausmodellen chronisch-entzündlicher Darmerkrankungen
(Applicant
Bachmann, Oliver
)
Regulation of liver regeneration by microRNAs
(Applicant
Sharma, Ph.D., Amar Deep
)
Role of Atg7 in Liver Damage and Regeneration
(Applicant
Buitrago Molina, Laura Elisa
)
Role of hepatitis E virus (HEV) infection in the induction of autoimmune hepatitis (AIH)
(Applicant
Cornberg, Markus
)
Selective enrichment of polymorphic sequences (SEPS) for high throughput analysis of the animal genome (Selektive Anreicherung polymorpher Sequenzen für Hochdurchsatzanalyse des tierischen Genoms)
(Applicant
Niemann, Heiner
)
Targeted mutagenesis in somatic for controlled transgenic expression in pics
(Applicant
Niemann, Heiner
)
Targeting the mutanome of HCC by viral inflammation and tumor-directed vaccinations: a model for individualized tumor therapy
(Applicant
Kühnel, Florian
)
The anion transport protein Slc26a9 in the bronchial and intestinal epithelium: Physiological functions, pathophysiological relevance, and interaction with the anion channel CFTR
(Applicant
Seidler, Ursula
)
The loss of the dermatan sulfate proteoglycan decorin differentially affects cytokine and syndecan-1 expression during allergic inflammation
(Applicant
Seidler, Daniela G.
)
The role of "lipid raft" microdomains in the PDZ-adaptor protein-mediated NHE3 Regulation in the intestine
(Applicant
Seidler, Ursula
)
Untersuchungen zu Proliferation, phenotypischer Differenzierung und Genexpression von Hepatozyten und Hepatozytenvorläuferzellen in vitro und nach Transplantation in Alb-uPA/RAG-2 (CER-2) Mäuse
(Applicant
Ott, Michael
)
Untersuchungen zur Bedeutung des Transkriptionsfaktors Nrf2 für den Energiemetabolismus
(Applicant
Vogel, Arndt
)
Untersuchungen zur differentiellen Bedeutung des adaptiven Immunsystems für die FAA-induzierte Hepatitis und Hepatokarzinogenese
(Applicant
Vogel, Arndt
)
Verbesserung von DNA-Impfstoffen gegen retrovirale Infektionen durch die funktionelle Blockade von regulatorischen T-Zellen
(Applicant
Dittmer, Ulf
)
Research Fellowships
Completed projects
Analyse der akzellerierten Entstehung von protektiven CD8+ Memory T-Zellen nach Dendritischer Zellvakzinierung bei der Immunantwort gegen Tumor und bakterielle/virale Pathogene
(Applicant
Wirth, Thomas
)
A novel murine model for the functional in-vivo analysis of cholangiocarcinoma: a screen for new tumor suppressor genes and a detailed characterization of the model.
(Applicant
Saborowski, Anna Lena
)
Antigenpräsentation, Immunregulation und Effektorphase bei autoimmunem Diabetes
(Applicant
Jaeckel, Elmar
)
Möglichkeiten und Mechanismen der vivo Korrektur von Genmutation
(Applicant
Vogel, Arndt
)
Significance of heterologous immunity for the course and outcome of viral infections
(Applicant
Cornberg, Markus
)
The role of the endocannabinoid system in hepatocarcinogenesis: investigation of chemically and genetically induced hepatocarcinogenesis in FAAH, CB1 and CB2 knockout mice.
(Applicant
Mederacke, Ingmar
)
Priority Programmes
Completed projects
Investigations on epigenetic modulation during pre-implantation embryonic gene expression and its significance for the incidence of the large offspring syndrome
(Applicant
Niemann, Heiner
)
Zell- und molekularbiologische Analyse von De- und Redifferenzierungsvorgängen in porcinen und bovinen Kardiomyozyten in einem homologen und heterologen Kerntransfermodell
(Applicant
Niemann, Heiner
)
Clinical Research Units
Completed projects
Bedeutung von Bid für die Fibrogenese und Krzinogenese in der Leber
(Applicant
Vogel, Arndt
)
Entwicklung von Strategien der in vitro-Differenzierung und Transplantation embryonaler und hämatopietischer Stammzellen zur Behandlung von Lebererkrankungen
(Applicant
Ott, Michael
)
Optimierung der Diagnostik und Therapie der Autoimmunhepatitis
(Applicants
Jaeckel, Elmar
;
Taubert, Richard
)
Untersuchung zu spontanen intratumoralen Immunvorgängen und zur Reduktion von regulatorischen T-Zellen beim HCC
(Applicant
Greten, Tim F.
)
Reinhart Koselleck Projects
Completed projects
In vivo tissue engineering of patient specific chimeric liver tissue for whole organ liver transplantation
(Applicants
Niemann, Heiner
;
Ott, Michael
)
Research Units
Current projects
Deciphering the transport metabolomes of SLC26A3, SLC26A6 and SLC26A9 in the human gastrointestinal tract
(Applicant
Seidler, Ursula
)
FOR 5046: Integrated analysis of epithelial SLC26 anion transporters - from molecular structure to pathophysiology
(Spokesperson
Oliver, Dominik
)
Physiological function and transport mode of the anion transporter SLC26A9 in the gastric and alveolar epithelium
(Applicant
Seidler, Ursula
)
Physiological significance of the interaction between SLC26A3 and SLC26A6 with CFTR or NHE3 for secretion and absorption in the intestine
(Applicants
Amiri, Mahdi
;
Lamprecht, Hans Georg
)
Completed projects
Epigenetische Analyse der Eizell- und Embryonalentwicklung am Modellorganismus Rind
(Applicants
Haaf, Thomas
;
Niemann, Heiner
;
Wrenzycki, Christine
)
Improved multi-transgenic pig lines for xenotransplantation
(Applicant
Niemann, Heiner
)
In vitro Germ Cell Differentiation of Cord-Blood-derived Unrestricted Somatic Stem Cells (USSC)
(Applicant
Schöler, Hans Robert
)
Transcriptomics des präimplantativen Rinderembryos
(Applicants
Adjaye, James
;
Niemann, Heiner
)
Heisenberg Grants
Current projects
Developing RNA therapeutics for liver via in vivo cellular reprogramming and remodeling of hepatic cells
(Applicant
Sharma, Ph.D., Amar Deep
)
Collaborative Research Centres
Completed projects
Basolateral anion import pathways of the intestinal epithelium: Pathophysiological relevance in inflammatory bowel disease
(Project Head
Bachmann, Oliver
)
Biogenese und pathogenetische Bedeutung kleiner leucinreicher Proteoglycane
(Project Head
Seidler, Daniela G.
)
Cure of chronic hepatitis C - Long-term effects on HCV-specific and heterologous immune responses
(Project Heads
Cornberg, Markus
;
Wedemeyer, Heiner
;
Wölk, Benno
)
Elucidation of supportive microRNAs during hepatic specification of reprogrammed cells in liver cell therapy
(Project Heads
Cantz, Tobias
;
Sharma, Ph.D., Amar Deep
)
Erstellung und Expressionsanalyse von transgenen Schweinen für die Xenotransplantation
(Project Heads
Kreipe, Hans
;
Niemann, Heiner
;
Wonigeit, Kurt
)
Evolution of the Hepatitis C Virus (HCV)-specific T-Cell Receptor Repertoire in the Context of Heterologous Immunity: Implications for the Course of an Acute HCV Infection and HCV Vaccine Development
(Project Head
Cornberg, Markus
)
Graft-specific tolerance after transplantation
(Project Head
Jaeckel, Elmar
)
Identification, isolation and molecular characterization of immunomodulatory cells
(Project Heads
Geffers, Ph.D., Robert
;
Jaeckel, Elmar
)
Immunological and viral determinants of graft hepatitis C after liver transplantation in the context of novel antiviral therapies
(Project Heads
Ciesek, Sandra
;
Cornberg, Markus
;
Greten, Tim F.
;
von Hahn, Thomas
;
Wedemeyer, Heiner
)
Lebertransplantation bei viraler Hepatitis: Ätiologie, Pathogenese, Prognose und Prophylaxe der Reinfektion
(Project Heads
Manns, Michael Peter
;
Tillmann, Hans-Ludger
;
Trautwein, Christian
)
Lentiviral vector induced insertional mutagenesis in gene therapy of hereditary liver disease
(Project Heads
Modlich, Ph.D., Ute
;
Ott, Michael
)
Pathomechanismen des Cholestasesyndroms nach Lebertransplantation: Vergleich zwischen Patienten mit und ohne primär biliäre Zirrhose
(Project Heads
Böker, Klaus H.W.
;
Manns, Michael Peter
)
Regulation epithelialer Wundheilungsmechanismen der Darmmukosa durch subepithiale Myofibroblasten
(Project Head
Göke, Michael
)
Role of PDZ-adapter proteins of the NHERF family in the regulation of intestinal electrolyte transport and barrier function
(Project Head
Seidler, Ursula
)
Use of a pre-clinical pig model to characterize and modulate immune responses following liver cell transplantation
(Project Heads
Bock, Michael
;
Vondran, Florian
)
CRC/Transregios
Completed projects
Core facility for genetically engineered pig lines
(Project Heads
Kaup, Franz-Josef
;
Keßler, Barbara
;
Kues, Wilfried A.
;
Lucas-Hahn, Andrea
;
Niemann, Heiner
;
Petersen, Björn
;
Schnieke, Angelika
;
Wolf, Eckhard
)
Evaluation of Apoptosis Biomarkers that Determine the Chemosensitivity of Hepatocellular Carcinoma and Early Identification of Non-Responders to Anticancer Therapy
(Project Heads
Bantel, Heike
;
Lehner, Frank
)
Identification and functional characterization of cancer cell-derived, stroma-modulating factors in cholangiocarcinoma
(Project Heads
Saborowski, Anna Lena
;
Saborowski, Michael
)
Identification of Melecular Targets for Immune-Based Therapies in Hepatocellular Carcinoma
(Project Heads
Greten, Tim F.
;
Korangy, Firouzeh
;
Wirth, Thomas
)
Identification of molecular mechanisms conferring resistance to oncolytic viruses in HCC and implications for successful HCC virotherapy
(Project Heads
Eggert, Tobias
;
Kühnel, Florian
;
Lauer, Ulrich M.
)
Microsphere-based immuno-therapy of HCC
(Project Head
Wirth, Thomas
)
Modifying the porcine genome for xeno-organ transplantation
(Project Heads
Fischer, Konrad
;
Kues, Wilfried A.
;
Lucas-Hahn, Andrea
;
Niemann, Heiner
;
Petersen, Björn
;
Schnieke, Angelika
)
Optimization and evaluation of c-myc – directed liver cancer therapy
(Project Head
Vogel, Arndt
)
Preclinical assessment of decellularised (antigen-reduced), gene-modified porcine heart valves
(Project Heads
Büttner, Falk
;
Cebotari, Serghei
;
Haverich, Axel
;
Hilfiker, Andres
;
Martin, Ulrich
;
Niemann, Heiner
)
Regulatory T cells (Tregs) in xenotransplantation
(Project Heads
Jaeckel, Elmar
;
Noyan, Fatih
;
Pohla, Heike
)
Role off c-myc in Chronic Liver Injury and Hepatocarcinogenesis
(Project Head
Vogel, Arndt
)
Targeting the mutanome of liver cancer by viral oncoly-sis and tumor-directed immunotherapies
(Project Head
Kühnel, Florian
)
Viroimmunotherapy in HCC: Recruitment and Expansion of Dendritic Cells by Tumor-Specific Replicating Viruses
(Project Heads
Kubicka, Stefan
;
Kühnel, Florian
)
Major Research Instrumentation
Completed projects
Flow cytometer
Clinical Trials
Current projects
Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe year AfTer lIver transplantatiON (ALTERNATION) – a randomized, prospective, multicenter, open-label, controlled trial.
(Applicant
Taubert, Richard
)
Randomized, prospective, multicenter, open-label, controlled, parallel-group trial investigating the efficacy of add-on plasma-exchange as an adjunctive strategy against septic shock - 2 (EXCHANGE-2)
(Applicant
David, Sascha
)
Completed projects
Biliary Interventions in critically ill patients with Sclerosing Cholangitis
(Applicant
Wedemeyer, Heiner
)
WBP Fellowship
Current projects
Characterizing the tumor microenvironment of MASH-related HCC to unravel determinants of response and/or resistance to atezolizumab + bevacizumab
(Applicant
Almeida Valadas De Castro, Tiago
)
International Research Training Groups
Completed projects
GRK 1273: Strategies of Human Pathogens to Establish Acute and Chronic Infections
(Spokesperson
Suerbaum, Sebastian
)
GRK 1549: Molecular and Cellular Glyco-Sciences (MCGS). Understanding Structure/Function Relationships of Carbohydrate/Protein Interactions
(Spokesperson
Moerschbacher, Bruno
)
Research Training Groups
Current projects
GRK 2978: Understanding and Exploiting Adaptation to Therapy in Gastrointestinal Cancer
(Spokesperson
Heßmann, Elisabeth
)
Clusters of Excellence
Completed projects
EXC 62: From Regenerative Biology to Reconstructive Therapy (REBIRTH)
(Spokespersons
Haverich, Axel
;
Thum, Ph.D., Thomas
)
Graduate Schools
Completed projects
GSC 108: Hannover Biomedical Research School (HBRS)
(Spokesperson
Schmidt, Reinhold Ernst
)
Clusters of Excellence (ExStra)
Current projects
EXC 2155: RESIST - Resolving Infection Susceptibility
(Spokespersons
Förster, Reinhold
;
Hansen, Gesine
;
Schulz, Thomas
)
