Medizinische Hochschule Hannover
Institut für Biophysikalische Chemie
Address
Carl-Neuberg-Straße 1
30625 Hannover
Deutschland
GERiT
This institution in GERiT
30625 Hannover
Projects
Priority Programmes
Completed projects
Characterization of Actomyosin Binding Forces by Combining Molecular Genetic and AFM Approaches
(Applicant
Manstein, Dietmar J.
)
Dissection of formin pathways coordinating polarity with cell migration downstream of Ras signalling
(Applicant
Faix, Jan
)
Functional Characterisation of Myosin Motors (Funktionelle Charakterisierung von Myosinmotoren)
(Applicant
Manstein, Dietmar J.
)
Relating specific biochemical activities of ADF/cofilin family members to their physiological functions
(Applicant
Faix, Jan
)
Research Grants
Current projects
Actin-based Force Generation in the Vascular Endothelium
(Applicant
Manstein, Dietmar J.
)
Function of cortical formins in the motility of strongly adherent cells
(Applicant
Faix, Jan
)
Completed projects
Allosteric regulation of UDP-sugar pyrophosphorylases as a means to develop new anti-parasitic treatments
(Applicant
Fedorov, Roman
)
Allostery and Proteostasis of Regulated Actomyosin Systems in Human Cardiomyocytes
(Applicant
Manstein, Dietmar J.
)
Analysis of the molecular determinants of Apaf-1 function
(Applicant
Eschenburg, Susanne
)
C-Mannosylation of Thryptophan Residues - Characterization of Mammalian Enzymes and Functional and Structural Aspect of the Modification on Thrombospondin Type 1 Repeats
(Applicant
Bakker, Hendrikus Hans
)
Darstellung der Dynamik und Organisation subzellulärer Strukturen mit Hilfe der 4Pi-Laser-Scanning-Mikroskopie - HighLight 2004
(Applicant
Manstein, Dietmar J.
)
Dissecting the role of formins in large-scale endocytosis
(Applicant
Faix, Jan
)
Dissecting the role of I-BAR proteins in VASP clustering and actin assembly
(Applicant
Faix, Jan
)
Ena/VASP proteins in cell motility and adhesion
(Applicant
Faix, Jan
)
Functional Characterization of Unconventional Myosin Motors
(Applicant
Manstein, Dietmar J.
)
Myosin 1-mediated Exocytosis of Glucose Transporter Storage Vesicles
(Applicant
Manstein, Dietmar J.
)
Non-muscular actinopathies: Baraitser-Winter Cerebrofrontofacial syndrome and related disorders
(Applicants
Di Donato, Nataliya
;
Manstein, Dietmar J.
)
Novel roles of SCAR/WAVE subunits in the regulation of actin dynamics
(Applicant
Faix, Jan
)
Optimierung molekularer Motoren mit Hilfe von gelenkter Evolution
(Applicant
Tsiavaliaris, Georgios
)
Primase to polymerase switch at the lagging strand of the bacterial replication fork
(Applicant
Curth, Ute
)
Proteindesign auf der Basis der Restriktionsendonuklease EcoRI zur Generierung neuer Sequenzspezifitäten
(Applicant
Alves, Jürgen
)
Structural and mechanistic dissection of the myosin start-of-power stroke state and its importance for force production
(Applicants
Preller, Matthias
;
Tsiavaliaris, Georgios
)
Structure and Function of Dynamin and Dynamin-Related Proteins
(Applicant
Manstein, Dietmar J.
)
Struktur-Funktionsbeziehung des c-Myb Protoonkogenproduktes und seiner Kofaktoren
(Applicant
Wolfes, Heiner
)
Tropomyosin-regulated actomyosin-based contractility in nonmuscles cells
(Applicant
Manstein, Dietmar J.
)
Research Units
Completed projects
Cell Cycle dependent changes in myosin 1 functions
(Applicant
Tsiavaliaris, Georgios
)
Characterization of the actomyosin binding interface
(Applicants
Mannherz, Hans Georg
;
Manstein, Dietmar J.
)
Characterization of the molecular interplay between VASP, formins and their accessory proteins during filopodium formation
(Applicant
Faix, Jan
)
FOR 629: Molecular Mechanisms of Cell Motility
(Spokesperson
Manstein, Dietmar J.
)
Generierung monoklonaler Antikörper, Unterstützung der Proteinanalyse durch Massenspektrometrie und der Produktion rekombinanter Proteine in Insektenzellen
(Applicants
Manstein, Dietmar J.
;
Wehland, Jürgen
)
Koordination und Öffentlichkeitsarbeit
(Applicant
Manstein, Dietmar J.
)
Major Research Instrumentation
Completed projects
Analytical ultracentrifuge
Analytische Ultrazentrifuge
High-throughput incubation and imaging system for crystal growth
Inverted laser scanning microscope
Konfokales Laserscanning-Mikroskop für Lebendzellbeobachtungen
Protein-Kristallisationssystem
Protein-Röntgen-Diffraktometer
Protein-Röntgenscanner
Schnelles Laser-Mikroskopsystem für Lebendzellbeobachtungen mit TIRF und FRAP/PA Erweiterungen
Research Fellowships
Completed projects
Dissection of the coordinated regulation of actin and microtubule dynamics by mDia1 and APC in reconstituted systems by advanced TIRF microscopy and single-molecule analysis
(Applicant
Breitsprecher, Dennis
)
Research Training Groups
Completed projects
GRK 388: Biotechnology: Biochemical and Molecular Foundation
(Spokesperson
Wink, Michael
)
Graduate Schools
Completed projects
GSC 108: Hannover Biomedical Research School (HBRS)
(Spokesperson
Schmidt, Reinhold Ernst
)
Clusters of Excellence (ExStra)
Current projects
EXC 2155: RESIST - Resolving Infection Susceptibility
(Spokespersons
Förster, Reinhold
;
Hansen, Gesine
;
Schulz, Thomas
)
