Universitätsklinikum Münster
Institut für Muskuloskelettale Medizin
Address
Albert-Schweitzer-Campus 1
48149 Münster
Deutschland
GERiT
This institution in GERiT
48149 Münster
Projects
Emmy Noether Independent Junior Research Groups
Completed projects
Modulation der Aggressivität synovialer Fibroblasten bei Rheumatoid Arthritis durch retroviralen Gentransfer von Antisensekonstrukten gegen Apoptoseinhibitoren
(Applicant
Pap, Thomas
)
Untersuchung zur Entstehung und Beeinflussung von Frühstadien der Membranentstehung bei aseptischer Endoprothesenlockerung in einem Wistarratten-Modell
(Applicant
Pap, Thomas
)
Emmy Noether International Fellowships
Completed projects
Untersuchung der Funktion von Ubiquitin-Ligase-Grail in vivo - T-Zell-spezifische Inaktivierung eines Anergiefaktors
(Applicant
Kriegel, Martin
)
Research Grants
Current projects
Adapting bioresorbable Mg-Fe Implants in bone healing
(Applicant
Stange, Richard
)
Analysis of the influence of Heparan sulfate proteoglycan Syndecan-1 on osteoclastogenesis and neoangiogenesis in chondro-osseous remodeling during fracture healing and potential therapeutic strategies
(Applicants
Adams, Ralf H.
;
Stange, Richard
)
Bone matrix-embedded osteocytes and their regulatory function in bone remodelling during rheumatoid arthritis
(Applicant
Wehmeyer, Corinna
)
Efficacy of simultaneous blockade of myostatin and activin on the inhibition of joint destruction in experimental arthritis
(Applicant
Dankbar, Ph.D., Berno
)
Role and underlying mechanisms of integrin α2β1 related cell-matrix interaction in tendon homeostasis and age related degradation
(Applicant
Stange, Richard
)
Targeting TRPC6 as a mechanosensitive signalling hub linking inflammation and structural damage in osteoarthritis.
(Applicant
Sherwood, Ph.D., Joanna
)
The role of osteoclasts and blood vessels as mediators downstream of beta-catenin in the differentiation of osteoblasts derived from two origins – chondrocytes and perichondrium
(Applicant
Hartmann, Christine
)
The role of WAVE Complex in osteoclast-mediated bone destruction in experimental arthritis
(Applicants
Dankbar, Ph.D., Berno
;
Stradal, Theresia
)
Completed projects
Analysis of the regulation of trabecular bone formation during mouse embryogenesis
(Applicant
Hartmann, Christine
)
Analysis of the roles of the Wnt-ligands Wnt9a and Wnt4 in adult bone and joint homeostasis
(Applicant
Hartmann, Christine
)
Beta-arrestin-2 and G-protein dependent signaling to stimulate fracture healing with parathyroid hormone
(Applicant
Stange, Richard
)
Das autonom zellgängige bakterielle Effektorprotein YopM als neues biologisches Therapeutikum der rheumatoiden Arthritis
(Applicant
Pap, Thomas
)
Das LIM-Domänen Protein FHL2 als neuer Regulator des aggressiv-invasiven Verhaltens synovialer Fibroblasten bei rheumatoider Arthritis.
(Applicant
Pap, Thomas
)
Die Rolle der SUMO-Protease SENP7 bei der stabilen Aktivierung synovialer Fibroblasten bei rheumatoider Arthritis.
(Applicant
Pap, Thomas
)
Expression von IL-16 in synovialen Fibroblasten
(Applicants
Aicher, Wilhelm K.
;
Pap, Thomas
)
Krankheitsspezifische Induktion der Serinprotease FAP in der rheumatoiden Arthritis: Funktion und Regulation bei der osteoklastären Knochendestruktion.
(Applicant
Dankbar, Ph.D., Berno
)
Maligne Knochentumore: Modulation von Apoptose und Invasion durch den Gewebeinhibitor von Metalloproteinasen-3 (TIMP-3)
(Applicant
Dankbar, Ph.D., Berno
)
Mechanismen der Apoptoseregulation durch SUMO-spezifische Proteasen in synovialen Fibroblasten von Patienten mit rheumatoider Arthritis
(Applicant
Pap, Thomas
)
Mechanisms of Integrin α2β1 driven cell-matrix interaction in the course of bone regeneration and fracture healing
(Applicant
Stange, Richard
)
Regulation of chronic inflammation in psoriatic-Arthritis by S100A8 and S100A9, Mechanisms and therapeutic implications.
(Applicant
Stratis, Athanasios
)
Regulation of cytokine-dependent calcification of cartilage tissue by NPP1 and syndecan-4
(Applicant
Pap, Thomas
)
Regulation of fibroblast response to IL-1 in rheumatoid arthritis by the transmembrane heparane sulfate proteoglycan syndecan-4
(Applicant
Pap, Thomas
)
Regulation of inflammatory bone destruction in rheumatoid arthritis by the small ubiquitin-like modifyer SUMO-1
(Applicant
Pap, Thomas
)
Syndecan-4 as a regulator of chondroblast development during fracture healing
(Applicant
Stange, Richard
)
The protective function of the Wnt inhibitor sclerostin in inflammatory bone destruction.
(Applicant
Dankbar, Ph.D., Berno
)
The role of macrophages during embryonic endochondralen ossification in wild-type and osteoclast deficient mice.
(Applicant
Hartmann, Christine
)
The role of the heparansulfate proteoglycan syndecan-1 in bone metabolism
(Applicant
Stange, Richard
)
The Role of Tolloid Proteinases in bone physiology and fracture healing
(Applicant
Kronenberg, Daniel
)
Unraveling Smad2/4-dependent osteoclast differentiation through transcriptome analysis
(Applicants
Dankbar, Ph.D., Berno
;
Kornak, Uwe
)
Untersuchung der rheumatischen Knorpelzerstörung mit Hilfe eines neu etablierten in vitro Modells (MATRIN-Assay) unter Verwendung von authentischen Kollagenmatrizes
(Applicant
Hansen, Uwe
)
Priority Programmes
Completed projects
Crosstalk between inflammation, bone destruction and new bone formation in patients with ankylosing spondylitis
(Applicant
Syrbe, Uta
)
Heparan sulfate in Degenerating Joint Diseases
(Applicant
Vortkamp, Andrea
)
The impact of myostatin on breast cancer and multiple myeloma bone metastases
(Applicant
Dankbar, Ph.D., Berno
)
The role of myostatin in joint destruction in rheumatoid arthritis
(Applicant
Dankbar, Ph.D., Berno
)
Research Units
Current projects
FOR 2722: Novel molecular determinants for musculoskeletal extracellular matrix homeostasis – a systemic approach (M2)
(Spokesperson
Brachvogel, Bent
)
Matrix mediated fibroblast activation in rheumatoid arthritis
(Applicants
Korb-Pap, Adelheid
;
Pap, Thomas
)
Collaborative Research Centres
Completed projects
Mechanisms of transendothelial fibroblast migration in rheumatoid arthritis
(Project Head
Pap, Thomas
)
Myostatin-induced mechanisms of inflammatory bone and cartilage destruction by invasive fibroblast-like synoviocytes
(Project Heads
Dankbar, Ph.D., Berno
;
Pap, Thomas
)
Regulation of Fibroblast Attachment and Invasiveness by PI3KGamma-Mediated Signalling Pathways in Rheumatoid Arthritis
(Project Head
Pap, Thomas
)
Major Research Instrumentation
Completed projects
Micro-CT
Research Fellowships
Completed projects
Function and Regulation of the Transmembrane Glycoprotein Podoplanin in Inflammatory Bone Destruction in Rheumatoid Arthritis
(Applicant
Wehmeyer, Corinna
)
Regulation of the proteoglycan switch in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) by the LIM and SH3 domain protein (Lasp) 1
(Applicant
Beckmann, Denise
)
