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Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Fakultät
Institut für Klinische Chemie und Klinische Pharmakologie
Address
Venusberg-Campus 1
53127 Bonn
Deutschland
GERiT
This institution in GERiT
53127 Bonn
Projects
Research Grants
Current projects
Nuclear receptors as metabolic relays of ILC2-mediated immune responses
(Applicant
Wilhelm, Ph.D., Christoph
)
The role of cell type-specific type I interferon production in the pathogenesis of systemic autoimmunity
(Applicant
Behrendt, Rayk
)
Completed projects
Characterization and mathematical modeling of the pathogenic IFN response caused by defects of the Aicardi-Goutières syndrome gene SAMHD1.
(Applicant
Behrendt, Rayk
)
Modulation of the host cell cholesterol metabolism by Eimeria bovis
(Applicant
Taubert, Anja
)
Pilot Study on early space closure to prevent gingival invaginations
(Applicant
Reichert, Christoph
)
Regulation of IFN-alpha and IFN-beta synthesis in plasmacytoid dendritic cells by two distinct types of CpG oligonucleotides
(Applicant
Hartmann, Gunther
)
The Influence of cap methylations on recognition by immune receptors and components of the translation machinery
(Applicant
Schlee, Martin
)
The role of ketogenesis in the immune response towards SARS-CoV-2
(Applicants
Bode, Christian
;
Wilhelm, Ph.D., Christoph
)
Clinical Research Units
Completed projects
Einsatz immunstimulatorischer Oligonukleotide im enteralen Immunsystem
(Applicant
Hartmann, Gunther
)
Immune biomarker- and microRNA-guided dose escalation phase I clinical study of a RIG-Iigand for the treatment of multiple sclerosis
(Applicant
Hartmann, Gunther
)
Priority Programmes
Current projects
Potentiating ferroptosis as treatment of allergic airway inflammation
(Applicant
Wilhelm, Ph.D., Christoph
)
The importance of lipid metabolism for the maintenance of pathogenic ILC2 responses
(Applicant
Wilhelm, Ph.D., Christoph
)
Completed projects
Defining the bio-molecular features of pigment cell-specific NK cell memory
(Applicant
Wilhelm, Ph.D., Christoph
)
Collaborative Research Centres
Current projects
Metabolic characterization of innate lymphoid cells in small cell lung cancer
(Project Head
Surace, Ph.D., Laura
)
Systematic Profiling of Genetic Components of Inflammasome Activation during Metaflammation
(Project Head
Schmid-Burgk, Jonathan Leo
)
The importance of ILC2-intrinsic lipid metabolism for the prevention of metaflammation
(Project Head
Wilhelm, Ph.D., Christoph
)
Completed projects
Activation modes of RIG-I
(Project Heads
Hartmann, Gunther
;
Schlee, Martin
)
Antigen-unabhängige Regulation der Effektorfunktion von NKT-Zellen und CD8 T-Zellen durch die plasmazytoide dendritische Zelle
(Project Head
Hartmann, Gunther
)
Local control of melanocyte-specific CD4+ T cell effector functions in melanomas
(Project Heads
Barchet, Winfried
;
Tüting, Thomas
)
Oligonucleotide-based chemical and immunomodulation of local liver infection
(Project Head
Hartmann, Gunther
)
Oxidatively modified DNA as immune adjuvant and autoimmune trigger in the skin
(Project Head
Barchet, Winfried
)
Physiological role of oxidized DNA recognition in the cytosol
(Project Head
Barchet, Winfried
)
Retinoic acid inducible gene I (RIG-I) in tumor biology: RIG-I-induced exosomes in the tumor mi-croenvironment
(Project Head
Hartmann, Gunther
)
Research Fellowships
Completed projects
Metabolic regulation of epigenetic asymmetry in CD8 T lymphocytes
(Applicant
Liedmann, Swantje
)
CRC/Transregios
Current projects
Central tasks of the Collaborative Research Centre
(Project Heads
Hartmann, Gunther
;
Hornung, Veit
)
Dissecting immune sensing of viral RNA at the insect-vertebrate barrier to guide improved messenger RNA vaccine design
(Project Heads
Hartmann, Gunther
;
Kümmerer, Beate
;
Schlee, Martin
)
Higher-order structures of ligand bound RIG-I and cGAS
(Project Heads
Geyer, Matthias
;
Schlee, Martin
)
Mobile genetic elements as sources of endogenous immune-stimulatory nucleic acids
(Project Head
Behrendt, Rayk
)
Role of self RNA in immune sensing and tolerance
(Project Heads
Bauer, Stefan
;
Zillinger, Thomas
)
Systematic dissection of cytosolic DNA sensing and signalling with nanobodies and proteomics
(Project Heads
Hartmann, Gunther
;
Meissner, Felix
;
Schmidt, Florian Ingo
)
The innate immune sensors RIG-I and MDA5 in aortic inflammation and calcification
(Project Head
Hartmann, Gunther
)
TRR 237: Nucleic Acid Immunity
(Spokespersons
Hartmann, Gunther
;
Hornung, Veit
)
Independent Junior Research Groups
Completed projects
Immunorecognition of viral nucleic acids in the cytosol
(Applicant
Barchet, Winfried
)
Clinical Trials
Completed projects
Evaluation of novel serological markers for early diagnosis of colorectal neoplasia SID 85
(Applicant
Brenner, Hermann
)
International Research Training Groups
Current projects
GRK 2168: Myeloid antigen presenting cells and the induction of adaptive immunity
(Spokesperson
Kurts, Christian
)
Clusters of Excellence (ExStra)
Current projects
EXC 2151: ImmunoSensation2 - the immune sensory system
(Spokespersons
Hartmann, Gunther
;
Kolanus, Waldemar
;
Latz, Eicke
;
Schultze, Joachim L.
)
Clusters of Excellence
Completed projects
EXC 1023: ImmunoSensation: The Immune Sensory System
(Spokesperson
Hartmann, Gunther
)
Additional Information
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