Gene regulatory programs in autosomal dominant polycystic kidney disease (P17*)

• Subject Area: Anatomy and Physiology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

P17 will identify cell type-specific transcriptional and epigenetic programs in ADPKD using a combination of single cell multiomics, spatial transcriptomics and chromatin profiling. Loss of PKD1 leads to cyst formation with substantial cellular remodeling and subsequent immune cell infiltration. Thus, P17 will investigate disease initiation and progression in mice with conditional inactivation of Pkd1 at defined time points to uncover cell type-specific gene-regulatory programs and cellular interactions during the course of ADPKD.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Michael Köttgen, since 1/2025; Dr. Sebastian Preißl, since 1/2025