SFB 612:
Molecular Analysis of Cardiovascular Function and Dysfunction
Subject Area
Medicine
Biology
Term
from 2002 to 2012
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5485180
Central theme of the collaborative research centre 612 is the study of molecular regulatory circuits which control the adaptation of an organism or tissue to functional perturbations or disease at the genomic, biochemical and functional level. It is the complex transition of a given genotype to the resulting phenotype which will be studied using modern methods of molecular biology, genome analysis and integrative physiology. Particularly emphasis is on the generation of transgenic mouse mutants which are created to study the role of contractile proteins, transcription factors, enzymes and transport functions for the heart and the circulatory system. Conventional knock-out strategies will be used as well as regulatable and tissue specific gene expression. The analysis of the cardiovascular system in the mouse includes the development of innovative techniques and miniaturisation of classical physiological procedures including high resolution imaging for the non-invasive analysis of cardiac structure and function. The interplay of genomic and protein analytical data with the functional analysis of multicellular systems of different complexity is the new challenge for the majority of the projects. Six projects are cardiac orientated while seven projects deal with the vascular system including angiogenesis. Core facilities are established for bioanalytical work, cardiovascular phenotyping of transgenic mice as well as their generation.
DFG Programme
Collaborative Research Centres
International Connection
Netherlands
Completed projects
-
A01 - Analyse of the cardiovascular function of Ftm and Fto
(Project Head
Rüther, Ulrich
)
-
A02 - Analysis of sarcomeric dysfunctions in hypertrophic and dilated cardiomyopathy caused by mutations of the troponin complex
(Project Heads
Pfitzer, Gabriele
;
Stehle, Robert
)
-
A03 - Funktionelle Bedeutung von Sorcin für die Regulation der myokardialen Ca2+-Homöostase und Kontraktilität
(Project Heads
Bölck, Birgit
;
Frank, Konrad
;
Schwinger, Robert H.G.
)
-
A04 - Lokale Funktion, NO-Bildung und Substrat-Selektion in Hoch- und Niedrigflussarealen des Herzens
(Project Heads
Decking, Ulrich K.M.
;
Schlack, Wolfgang
)
-
A05 - Mechanisms of AKT mediated signal transduction in cardiac myocytes
(Project Head
Gödecke, Axel
)
-
A06 - Signalwege und funktionelle Bedeutung des myokardialen EP4-Rezeptors
(Project Heads
Hohlfeld, Thomas
;
Meyer-Kirchrath, Jutta
)
-
A07 - In-vivo-Mobilität ß-adrenerger Rezeptoren und der Effekt kardiopathogener Rezeptorautoantikörper
(Project Heads
Boege, Friedrich
;
Mielke, Christian
)
-
A08 - Di-protein-dependent cardiovascular homeostasis
(Project Head
Piekorz, Roland
)
-
A09 - Mechanisms of the development of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficiency
(Project Head
Spiekerkötter, Ute
)
-
B1 - Mechanismen und Regulatoren der postnatalen Vaskulogenese
(Project Heads
Kalka, Christoph
;
Krone, Wilhelm
)
-
B02 - Modulation of platelet thrombogenicity by genetically determined variants of platelet integrins
(Project Head
Scharf, Rüdiger Eberhard
)
-
B3 - Bedeutung von Pleiotrophin und seiner Bindungsproteine für die Funktion der Endothelzelle
(Project Head
Kiefer, Paul
)
-
B05 - Die Bedeutung der hämatogenen NO-Synthese für die vaskuläre Homöostase
(Project Heads
Jax, Thomas
;
Kelm, Malte
)
-
B06 - Functional role of CD73/ecto-5'-nucleotidase-derived extracellular adenosine in vascular inflammation
(Project Head
Schrader, Jürgen
)
-
B07 - Gentransfer in Gefäßmuskelzellen über Adhäsionsmoleküle mittels Tropismus-modifizierter adenoviraler Vektoren
(Project Heads
Kochanek, Stefan
;
Schrör, Karsten
)
-
B08 - Die Bedeutung der Apoptose und Caspase-vermittelten Freisetzung von Lysophosphatidylcholin in der Atherosklerose
(Project Head
Schulze-Osthoff, Klaus
)
-
B09 - Molekulare und funktionelle Charakterisierung der Prostaglandin-abhängigen Hyaluron-säuresynthese in glatten Gefäßmuskelzellen
(Project Head
Fischer, Jens W.
)
-
B10 - Importance of class IA PI 3-Kinase isoforms for the pathogenesis of pulmonary hypertension
(Project Head
Rosenkranz, Stephan
)
-
B11 - Function of the protease-activated receptor-2 (PAR-2) for thrombus generation and atherogenesis and vascular smooth muscle cells
(Project Head
Rauch, Bernhard Hermann
)
-
B12 - Regulation of the myosin phosphatase by cyclic nucleotides in the vascular system
(Project Head
Pfitzer, Gabriele
)
-
B14 - Influence of netrins and their receptors on the pathoogical neovascularization in the retina
(Project Heads
Joussen, Antonia
;
Koch, Manuel
)
-
B15 - Characterization of the molecular mechanisms of caffeine action in the vascular system
(Project Head
Haendeler, Judith
)
-
B16 - Role of BAX-inhibitors (BI-1) in the pathogenesis of atherosclerosis
(Project Head
Brüning, Jens Claus
)
-
B18 - Molecular mechanisms of angiotensin II-mediated proteinuria at the slit diaphragm
(Project Heads
Rump, Lars Christian
;
Sellin, Lorenz
)
-
Z01 - Bioanalytical Core Facility
(Project Heads
Köhrer, Karl
;
Lercher, Martin
)
-
Z02 - Cardiovascular phenotyping of transgenic mice
(Project Heads
Flögel, Ulrich
;
Schrader, Jürgen
)
-
Z03 - Herstellung von transgenen Mäusen und Verlustmutanten
(Project Head
Rüther, Ulrich
)
-
Z04 - Zentrale Aufgaben des Sonderforschungsbereichs
(Project Head
Schrader, Jürgen
)