Project Details
Projekt
TRR 3: Mesial Temporal Lobe Epilepsies
Subject Area
Medicine
Term
from 2001 to 2012
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5484905
This transregional consortium of laboratories at the universities of Bonn, Berlin, Magdeburg, Freiburg and Jerusalem is focussed on two main areas: (a) pathomechanisms of mesial temporal lobe epilepsy and (b) mechanisms of memory and emotional processing in the mesolimbic system and their dysfunctions. Major issues are:
(1) Which are the cellular and molecular changes that lead to an increased potential to generate seizures? - Genetics of the epilepsies, neurotransmitter-receptors, ion channels, intracellular signal transduction molecules, extracellular matrix components, and altered glial cell properties.
(2) How do structural and functional changes in the brain develop during the course of epilepsy, and what are the mechanisms responsible for chronification of the disease? - Pathogenesis and pathophysiology of Ammon's horn sclerosis, structural plasticity, functional plasticity, neurogenesis, animal models - Studies focus on both the amygdala as well as on the hippocampus.
(3) Development of new therapeutic strategies - Modified surgical procedures, seizure prediction, identification of pharmacological targets, implantation of ES-cell derived neural precursors.
(4) Mechanisms of memory and emotional processing in the mesolimbic system and their dysfunctions - Memory, emotion, perception, functional circuits within the human limbic system.
(1) Which are the cellular and molecular changes that lead to an increased potential to generate seizures? - Genetics of the epilepsies, neurotransmitter-receptors, ion channels, intracellular signal transduction molecules, extracellular matrix components, and altered glial cell properties.
(2) How do structural and functional changes in the brain develop during the course of epilepsy, and what are the mechanisms responsible for chronification of the disease? - Pathogenesis and pathophysiology of Ammon's horn sclerosis, structural plasticity, functional plasticity, neurogenesis, animal models - Studies focus on both the amygdala as well as on the hippocampus.
(3) Development of new therapeutic strategies - Modified surgical procedures, seizure prediction, identification of pharmacological targets, implantation of ES-cell derived neural precursors.
(4) Mechanisms of memory and emotional processing in the mesolimbic system and their dysfunctions - Memory, emotion, perception, functional circuits within the human limbic system.
DFG Programme
CRC/Transregios
International Connection
Israel
Completed projects
- A01 - Subtemporal vs. transsylvian approach for selective amygdalohippocampectomy: a randomized controlled trial on the epileptological and cognitive outcome (Project Heads Helmstaedter, Christoph ; Schramm, Johannes ; Weber, Bernd )
- A02 - Nichtlineare Analyse elektrischer Potentiale und magnetischer Felder im epileptischen Gehirn (Project Heads Grassberger, Peter ; Hinrichs, Hermann ; Lehnertz, Klaus )
- A03 - Funktionelle Organisation von Gedächtnisprozessen im menschlichen Temporallappen (Project Heads Kurthen, Martin ; Münte, Thomas F. ; Rosburg, Timm )
- A4 - Struktur-Funktions-Untersuchungen an gedächtnisrelevanten Strukturen (Project Heads Fernández, Guillén ; Heinze, Hans-Jochen ; Rotte, Michael )
- A5 - Genetische Grundlagen von Temporallappen-Epilepsien (Project Heads Gu, Wenli ; Propping, Peter ; Steinlein, Ortrud Kristina )
- A06 - Die strukturellen und funktionellen Langzeitfolgen von medialen Schläfenlappenresektionen auf limbische und neokortikale Verbindungen des Hippokampus und der parahippokampalen Region (Project Heads Düzel, Emrah ; Elger, Christian E. ; Heinze, Hans-Jochen )
- A07 - Metabolitgehalte des epileptischen Hippokampus von Mensch und Ratte: Welche Beziehung haben die NMR Spektren zum Stoffwechsel? (Project Heads Heinze, Hans-Jochen ; Kunz, Wolfram S. ; Skalej, Martin ; Vielhaber, Stefan )
- A08 - Temporal lobe epilepsy and advenced white matter fractional anisotropy analysis (Project Heads Deppe, Michael ; Elger, Christian E. ; Weber, Bernd )
- A09 - Neural synchronization in mesiotemporal lobe epilepsy: relation to memory function and pathology (Project Heads Axmacher, Nikolai ; Fell, Jürgen )
- A10 - How do functional and structural lesions in temporal lobe epilepsy affect developing cognitive neural networks? (Project Heads Helmstaedter, Christoph ; Knecht, Stefan )
- A11 - Mitochondrial genetic risk factors for temporal lobe epilepsy (Project Head Kunz, Wolfram S. )
- B1 - Rolle von Cajal-Retzius und Reelin bei Migrationsstörunen in der Hippocampus-Entwicklung (Project Heads Frotscher, Michael ; Förster, Eckart ; Haas, Carola A. )
- B2 - Epilepsie-assoziierte Veränderungen in der strukturellen und molekularen Organization der menschlichen Amygdala (Project Heads Blümcke, Ingmar ; Schramm, Johannes ; Schwegler, Herbert ; Yilmazer-Hanke, Deniz )
- B3 - Untersuchungen zur Konnektivität des menschlichen Hippocampus bei Temporallappen-Epilepsie (Project Heads Deller, Thomas ; Freiman, Thomas ; Frotscher, Michael )
- B04 - Gating of hippocampal output in temporal lobe epilepsy (Project Heads Behr, Joachim ; Lehmann, Thomas-Nicolas )
- B05 - Functional and structural alterations in hippocampal inhibitory innervation in mesial temporal lobe epilepsy (Project Heads Gloveli, Tengis ; Meier, Jochen )
- B06 - Plastizitätsänderungen in der Amygdala bei tierexperimentellen Modellen der Temporallappenepilepsie (Project Head Albrecht, Doris )
- B07 - Neurophysiologische Korrelate anfallsbezogener Einflüsse auf Furchtverhalten und Furchtgedächtnis in amygdalo-hippocampalen Schaltkreisen (Project Heads Pape, Hans-Christian ; Seidenbecher, Thomas )
- B08 - Epilepsy as synaptopathy: Plasticity of the presynaptic release machinery (Project Heads Becker, Albert ; Schoch McGovern, Susanne )
- B09 - Cholinerge Übertragungsprozesse bei mesialen Temporallappenepilepsien (Project Heads Friedman, Alon ; Heinemann, Uwe )
- B10 - Glutamatergic synaptic transmission and plasticity in hippocampal microcircuits (Project Head Jonas, Peter )
- C01 - Altered cellular properties of astrocytes in human temporal lobe epilepsy (Project Heads Derouiche, Amin ; Steinhäuser, Christian )
- C02 - Role of subthreshold Na+ conductances in epileptogenesis (Project Heads Beck, Heinz ; Yaari, Yoel )
- C03 - Synaptic networks in the human lateral amygdala: contribution to the generation and maintenance of epileptiform activity (Project Heads Pape, Hans-Christian ; Speckmann, Erwin-Josef )
- C4 - Metaplastizität synaptischer Übertragung: Interaktion mit Gedächtnisprozessen bei humaner Epilepsie und Epilepsietiermodellen (Project Heads Beck, Heinz ; Elger, Christian E. ; Manahan-Vaughan, Denise )
- C05 - Verlust von neuronalen Ca2+-bindenden Proteinen bei Epilepsien: pathophysiologische Rolle (Project Heads Dietrich, Dirk ; Kral, Thomas )
- C06 - Antiepileptogenic approaches targeting the T-type Ca2+ channel Cav3.2 (Project Heads Becker, Albert ; Schoch McGovern, Susanne ; Yaari, Yoel )
- C07 - Molecular mechanisms of pharmacoresistance in epilepsy patients (Project Heads Beck, Heinz ; Elger, Christian E. ; Heinemann, Uwe )
- C08 - Temporal lobe epileptogenesis: role of blood-brain barrier disruption, albumin and TGFBeta in generation of temporal lobe epilepsy (Project Heads Friedman, Alon ; Heinemann, Uwe )
- C09 - Role of glial gap junctional coupling in development and progression of epilepsy (Project Heads Steinhäuser, Christian ; Theis, Martin )
- D1 - Molekulare Neuropathologie der Temporallappen-Epilepsie: Untersuchungen zur rolle metabotroper Glutamatrezeptoren (Project Heads Blümcke, Ingmar ; Wiestler, Otmar Dieter ; Zimmer, Andreas )
- D02 - Transplantation of ombryonic stem cell-derived neural prcursors into the epileptic hippocampus (Project Head Brüstle, Oliver )
- D3 - Interaktionen in amygdala-entorhinal-corticalen Schaltkreisen bei tierexperimentellen Modellen der Temporallappen-Epilepsie (Project Heads Albrecht, Doris ; Pape, Hans-Christian )
- D5 - Muskarinische Signal-Transduktion bei mesialen Temporallappen-Epilepsien (Project Heads Heinemann, Uwe ; Müller, Ph.D., Wolfgang )
- D06 - Roles of epileptic activity and Reelin in neurogenesis in the dentate gyrus (Project Heads Frotscher, Michael ; Haas, Carola A. )
- D07 - Experimentally induced granule cell dispersion as a model to study the role of migration defects in epilepsy (Project Heads Frotscher, Michael ; Haas, Carola A. )
- D09 - Epilepsie-induzierter neuronaler Zelltod: der JNK/c-Jun/Bim-Signaltransduktionsweg und Möglichkeiten der Intervention durch intrazellulären Proteintransfer (Project Head Frank, Stephan )
- D10 - A possible role of cortical spreading depolarisation for cellular damage in status epilepticus and subsequent development of temporal lobe epilepsy (Project Heads Dreier, Jens P. ; Gorji, Ali )
- D11 - Glutamate-mediated white matter damage during temporal lobe epilepsy (Project Heads Clusmann, Hans ; Dietrich, Dirk )
- D12 - Free radical formation and mitochondrial damage as key factors in epileptogenesis (Project Heads Kann, Oliver ; Kovács, Richard ; Kunz, Wolfram S. )
- N01 - N01 Molecular Biology of Temporal Lobe Epilepsy: Role of CPEB Proteins in neurons, microglia and astrolglial cells (Project Head Theis, Martin )
- Z01 - Central administrative service (Project Heads Elger, Christian E. ; Steinhäuser, Christian )
- Z2 - Stadortübergreifendes Koordinationsprojekt (Project Heads Elger, Christian E. ; Schramm, Johannes )
Applicant Institution
Rheinische Friedrich-Wilhelms-Universität Bonn
Co-Applicant Institution
Albert-Ludwigs-Universität Freiburg; Charité - Universitätsmedizin Berlin; Freie Universität Berlin; Humboldt-Universität zu Berlin; Universität Münster
Participating Institution
Ben-Gurion University of the Negev; Max-Delbrück-Centrum für Molekulare Medizin (MDC)
Participating University
The Hebrew University of Jerusalem
Spokespersons
Professor Dr. Christian E. Elger, until 12/2008; Professor Dr. Christian Steinhäuser, since 12/2008
