SPP 1050:  Funktionelle Architektur des Zellkerns

• Fachliche Zuordnung: Biologie
• Förderung: Förderung von 1998 bis 2007
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5468596

Keine Zusammenfassung vorhanden

• DFG-Verfahren: Schwerpunktprogramme

Projekte

• 3D-Genomstrukturerkennung durch zeitaufgelöste Fluoreszenzdetektion unter Einsatz von gepulsten Diodenlasern und Multiplexfarbstoffen (Antragsteller Wolfrum, Jürgen )
• Analyse von Proteinen, die mit der nukleären, Ras-ähnlichen GTPase Ran in Saccharomyces cerevisiae interagieren (Antragsteller Künzler, Markus )
• Analysis of chromosome territory arrangements in mouse stem cells and their derivatives in four dimensions (space and time) (Antragsteller Cremer, Thomas )
• Analysis of the 3D-nuclear-nanostructure in human Cells using Fluorescence Detection of Multiplex Dyes (Antragsteller Cremer, Christoph )
• Architecture and functional significance of nuclear laminae of different molecular composition (Antragsteller Stick, Reimer )
• Architektur der Kernperipherie meiotischer Zellen (Antragsteller Benavente, Ricardo )
• Assembly and possible functions of heterochromatin in Arabidopsis thaliana - The role of DNA methylation and histone modifications (Antragsteller Schubert, Ingo )
• Controlled nuclear uptake of DNA methyltransferase and targeting to functional domains within the nucleus (Antragsteller Leonhardt, Heinrich )
• Die Rolle der GTPase Ran bei der Translokation durch den Kernporenkomplex (Antragsteller Görlich, Dirk )
• Die Variabilität der Kerndomänen und der DNA-Proteinstruktur von Telomeren während der pflanzlichen Entwicklung Varibility of the nuclear domains and the DNA-protein structure of telomeres during plant development (Antragstellerin Zentgraf, Ulrike )
• Dynamic Organization of Chromatin Replication (Antragstellerin Cardoso, Maria Cristina )
• Dynamics of the nucleolar transcriptional machinery (Antragstellerin Grummt, Ingrid )
• Dynamics of the nucleolar transcriptional machinery (Antragstellerin Grummt, Ingrid )
• Functional Organisation of the nucleolus and characterization of export-competent preribosomes (Antragsteller Scheer, Ulrich )
• High resolution analysis of interchromosomal nuclear compartmentalization in situ and in vivo (Antragsteller Lichter, Peter )
• Identification and Characterization of Novel Components Involved in the Export of Ribosomes from the Nucleolus into the Cytoplasm (Antragsteller Hurt, Eduard Christian )
• In vivo Analyse der Struktur von Chromosomenterritorien: Dyanamische Veränderungen während des Zellzyklus und der terminalen Differenzierung von Zellen (Antragstellerin Zink, Daniele )
• In vivo dynamics of fluorescently labeled nuclear proteins (Antragsteller Langowski, Jörg )
• In vivo Interaktion von Proteinen der Kernhülle In vivo interactions of nuclear envelope proteins (Antragsteller Krohne, Georg )
• In vivo studies of the role of the RanGTPase in post-mitotic nuclear envelope assembly (Antragsteller Mattaj, Iain W. )
• Koordination des SPP (Antragsteller Scheer, Ulrich )
• Mobility of murine replication proteins in the nucleus (Antragsteller Grummt, Friedrich )
• Molecular characterisation and function of nucleolar and nuclear protein complexes involved in sequential maturation steps of ribosomal precursor particles (Antragsteller Tschochner, Herbert )
• Molecular characterization and function of novel structures in the karyoplasm (Antragsteller Franke, Werner Wilhelm )
• NLS-indepedent nucleocytoplasmic transport pathways of macromolecules (Antragsteller Schlenstedt, Gabriel )
• Nuclear export of proteins with leucine-rich nuclear export signals (NES) in vivo and in vitro (Antragstellerin Dabauvalle, Marie-Christine )
• Nukleärer Export in der Destabilisierung des P53-Tumorsuppressors durch virale und zelluläre Onkoproteine (Antragsteller Dobbelstein, Matthias )
• Optical single transporter analysis of the nuclear pore complex (Antragsteller Peters, Reiner )
• Pairing of homologous chromosomes: Physical arrangement and functional consequences in development (Antragstellerin Arndt-Jovin, Donna )
• Positioning and functional structure of repliction time zones at the cystic fibrosis gene locus (Antragstellerin Zink, Daniele )
• The Role of a Scaffold Attachment Factor in Nuclear Assembly and Architecture (Antragsteller Fackelmayer, Frank O. )
• Topogenesis and assembly of nucleolar proteins (Antragstellerin Schmidt-Zachmann, Marion-Susanne )
• Transport pathways of single molecules and nanoparticles in the nucleus of the living cell (Antragsteller Kubitscheck, Ulrich )
• Understanding complete transport cycles mediated by importin beta-type nuclear transport receptors in situ and in living cells (Antragsteller Görlich, Dirk )
• Understanding complete transport cycles mediated by importin beta-type nuclear transport receptors in situ and in living cells (Antragsteller Ellenberg, Jan )

• Sprecher: Professor Dr. Ulrich Scheer