SPP 1050:  Funktionelle Architektur des Zellkerns

• Subject Area: Biology
• Term: from 1998 to 2007
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5468596

No abstract available

• DFG Programme: Priority Programmes

Projects

• 3D-Genomstrukturerkennung durch zeitaufgelöste Fluoreszenzdetektion unter Einsatz von gepulsten Diodenlasern und Multiplexfarbstoffen (Applicant Wolfrum, Jürgen )
• Analyse von Proteinen, die mit der nukleären, Ras-ähnlichen GTPase Ran in Saccharomyces cerevisiae interagieren (Applicant Künzler, Markus )
• Analysis of chromosome territory arrangements in mouse stem cells and their derivatives in four dimensions (space and time) (Applicant Cremer, Thomas )
• Analysis of the 3D-nuclear-nanostructure in human Cells using Fluorescence Detection of Multiplex Dyes (Applicant Cremer, Christoph )
• Architecture and functional significance of nuclear laminae of different molecular composition (Applicant Stick, Reimer )
• Architektur der Kernperipherie meiotischer Zellen (Applicant Benavente, Ricardo )
• Assembly and possible functions of heterochromatin in Arabidopsis thaliana - The role of DNA methylation and histone modifications (Applicant Schubert, Ingo )
• Controlled nuclear uptake of DNA methyltransferase and targeting to functional domains within the nucleus (Applicant Leonhardt, Heinrich )
• Die Rolle der GTPase Ran bei der Translokation durch den Kernporenkomplex (Applicant Görlich, Dirk )
• Die Variabilität der Kerndomänen und der DNA-Proteinstruktur von Telomeren während der pflanzlichen Entwicklung Varibility of the nuclear domains and the DNA-protein structure of telomeres during plant development (Applicant Zentgraf, Ulrike )
• Dynamic Organization of Chromatin Replication (Applicant Cardoso, Maria Cristina )
• Dynamics of the nucleolar transcriptional machinery (Applicant Grummt, Ingrid )
• Dynamics of the nucleolar transcriptional machinery (Applicant Grummt, Ingrid )
• Functional Organisation of the nucleolus and characterization of export-competent preribosomes (Applicant Scheer, Ulrich )
• High resolution analysis of interchromosomal nuclear compartmentalization in situ and in vivo (Applicant Lichter, Peter )
• Identification and Characterization of Novel Components Involved in the Export of Ribosomes from the Nucleolus into the Cytoplasm (Applicant Hurt, Eduard Christian )
• In vivo Analyse der Struktur von Chromosomenterritorien: Dyanamische Veränderungen während des Zellzyklus und der terminalen Differenzierung von Zellen (Applicant Zink, Daniele )
• In vivo dynamics of fluorescently labeled nuclear proteins (Applicant Langowski, Jörg )
• In vivo Interaktion von Proteinen der Kernhülle In vivo interactions of nuclear envelope proteins (Applicant Krohne, Georg )
• In vivo studies of the role of the RanGTPase in post-mitotic nuclear envelope assembly (Applicant Mattaj, Iain W. )
• Koordination des SPP (Applicant Scheer, Ulrich )
• Mobility of murine replication proteins in the nucleus (Applicant Grummt, Friedrich )
• Molecular characterisation and function of nucleolar and nuclear protein complexes involved in sequential maturation steps of ribosomal precursor particles (Applicant Tschochner, Herbert )
• Molecular characterization and function of novel structures in the karyoplasm (Applicant Franke, Werner Wilhelm )
• NLS-indepedent nucleocytoplasmic transport pathways of macromolecules (Applicant Schlenstedt, Gabriel )
• Nuclear export of proteins with leucine-rich nuclear export signals (NES) in vivo and in vitro (Applicant Dabauvalle, Marie-Christine )
• Nukleärer Export in der Destabilisierung des P53-Tumorsuppressors durch virale und zelluläre Onkoproteine (Applicant Dobbelstein, Matthias )
• Optical single transporter analysis of the nuclear pore complex (Applicant Peters, Reiner )
• Pairing of homologous chromosomes: Physical arrangement and functional consequences in development (Applicant Arndt-Jovin, Donna )
• Positioning and functional structure of repliction time zones at the cystic fibrosis gene locus (Applicant Zink, Daniele )
• The Role of a Scaffold Attachment Factor in Nuclear Assembly and Architecture (Applicant Fackelmayer, Frank O. )
• Topogenesis and assembly of nucleolar proteins (Applicant Schmidt-Zachmann, Marion-Susanne )
• Transport pathways of single molecules and nanoparticles in the nucleus of the living cell (Applicant Kubitscheck, Ulrich )
• Understanding complete transport cycles mediated by importin beta-type nuclear transport receptors in situ and in living cells (Applicant Görlich, Dirk )
• Understanding complete transport cycles mediated by importin beta-type nuclear transport receptors in situ and in living cells (Applicant Ellenberg, Jan )

• Spokesperson: Professor Dr. Ulrich Scheer