Die Rolle des kostimulatorischen Moleküls CD137 bei Asthma bronchiale und bei Toleranz gegen Allergene

• Antragstellerin: Professorin Dr. Gesine Hansen
• Fachliche Zuordnung: Kinder- und Jugendmedizin
• Förderung: Förderung von 2003 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5417591

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model. Eur J Immunol 2005. 35: 198-206
  Scherf W, Burdach S, and Hansen G
  
• CD137-mediated immunotherapy for allergic asthma. J Clin Invest 2006. 116: 1025-1036
  Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G
  
• Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006. 116: 1025-1036
  Polte T, Behrendt AK, Hansen G
  
• CD137 ligand prevents the development of T-helper type 2 cell-mediated allergic asthma by interferon-gamma- producing CD8+ T cells. Clin Exp Allergy 2007. 37: 1374-1385
  Polte T, Jagemann A, Foell J, Mittler R S and Hansen G
  
• A versatile platform for comprehensive chip-based explorative cytometry. Cytometry A 2009. 75: 362-370
  Hennig C, Adams N, and Hansen G
  
• Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model. Eur J Immunol 2009. 39: 1736-1742
  Polte T, Fuchs L, Behrendt AK and Hansen G
  
• Different role of CD30 in the development of acute and chronic airway inflammation in a murine asthma model. Eur J Immunol. 2009. 39: 1736-42
  Polte T, Fuchs L, Behrendt AK, Hansen G
  
• CD27 costimulation is not critical for the development of asthma and respiratory tolerance in a murine model. Immunol Lett. 2010. 133: 19-27
  Behrendt AK, Hansen G
  
• Basophils from humans with systemic lupus erythematosus do not express MHC-II. Nat Med 2012. 18: 488-489; 489-490
  Dijkstra D, Hennig C, Witte T and Hansen G
  
• CD137 deficiency does not affect development of airway inflammation or respiratory tolerance induction in murine models. Clin Exp Immunol. 2012, 168: 308-17
  Behrendt, AK, Meyer-Bahlburg, A, Hansen, G
  (Siehe online unter https://doi.org/10.1111/j.1365-2249.2012.04572.x)
• ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance. J Immunol 2012. 189: 1975-1982
  Busse M, Krech M, Meyer-Bahlburg A, Hennig C and Hansen G
  (Siehe online unter https://doi.org/10.4049/jimmunol.1103581)