Einflüsse von Entzündungskaskaden auf Signaltransduktionen in Humanspermien und die Folgen für den Fertilisationsprozess

• Antragsteller: Professor Dr. Hans-Jürgen Glander
• Mitantragsteller: Professor Dr. Jürgen Arnhold
• Fachliche Zuordnung: Reproduktionsmedizin, Urologie ; Dermatologie
• Förderung: Förderung von 2002 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5367118

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Activation of caspases in human spermatozoa during cryopreservation - an inimurioblot study. Cell and Tissue Banking, 7, (2006) 81-90
  Wuendrich, K.. Paasch, U., Leicht, M., Glander, H.-J.
  
• Capacitation and acrosome reaction in non-apoptotic human spermatozoa. In: Signal transduction pathways, Part A: Molecular cell signaling mechanisms, Ann. N.Y. Acad. Sei.. Vol 1090, (2006) 138- 146
  Grunewald, S., Baumann, T.. Paasch, U., Glander, H.-J.
  
• Destabilisation of the acrosome results in release of phospholipase A2 from human spermatozoa and subsequent formation of lysophospholipids. Andrologia, 38 (2006) 69-75
  Leßig, J., Glander, H.-J., Schiller, J., Petkovic, M., Paasch, U., Arnhold, J.
  
• Evaluation of sperm recovery following annexin V magnetic-activated cell sorting separation. Reproductive BioMedicine Online. 13, (2006) 336-339
  Said, T.M., Agarwal, A., Grunewald, S., Rasch. M., Glander, H.-J., Paasch, U.
  
• Failure of phospholipid hydroperoxide glutathione peroxidase expression in oligoasthenozoospermia and mutations in the PHGPx gene. Andrologia, 38, (2006)152-157
  Diaconu, M., Tangat, Y., Böhm, D.. Kühn, H., Michelmann, H:W., Schreiber, G., Haidl, G., Glander, H.-J., Engel, W., Nayernia. K.
  
• Magnetic-activated cell sorting before cryopreservation preserves mitochondrial integrity in human spermatozoa. Cell and Tissue Banking, 7, (2006) 99-104
  Grunewald, S., Paasch, U., Said, T.M.. Rasch, M., Aganwal, A.. Glander, H.-J.
  
• Modification of amino acid residues in human serum albumin by myeloperoxidase. Free Radic. Biol. Med. 40 (2006) 515-525
  Salavej, H., Spalteholz, H., Arnhold, J.
  
• Selection of nonapoptotic spermatozoa as a new tool for enhancing assisted reproduction outcomes: an in vitro model. Biol. Reprod. 74 (2006). 530-537
  Said, T., Agarwal, A., Grunewald, S., Rasch, M., Baumann, T., Kriegel, C , Li, L., Glander, H.-J., Thomas, A.J.Jr., Paasch. U.
  
• Differential effects of flavonols on inactivation of a1-antitrypsin induced by hypohalous acid and the myeloperoxidase-hydrogen peroxide-halide system. Arch. Biochem. Biophys. 459 (2007) 137-142
  Bouriche. H., Salavei, P., Lessig, J., Arnhold, J
  
• Hypochlorous acid-mediated generation of glycerophosphocholine from unsaturated plasmalogen glycerophosphocholine lipids. J. Lipid Res. 48 (2007) 1316-1324
  Leßig, J., Schiller, J., Arnhold, J., Fuchs, B.
  
• Molecular glass wool filtration as a new tool for sperm preparation. Hum. Reprod., 22, (2007)1405-1412
  Grunewald, S., Miska, W., Miska, G.. Rasch, M.. Reinhardt, M., Glander, H.-J., Paasch, U.
  
• Myeloperoxidase binds to non-vital spermatozoa on phosphatidylserine epitopes. Apoptosis 12 (2007) 1803-1812
  Leßig, J., Spalteholz, H., Reibetanz, U., Salavei, P., Fischlechner, M., Glander, H.-J.. Arnhold, J.
  
• Sperm selection in assisted reproductive techniques. Soc. Reprod. Fertil. Suppl. 65, (2007)515-525
  Paasch, U., Grunewald, S., Glander. H.-J.
  
• Biology of Male Germ Cells, Shaker-Verlag, Aachen, 455 Seiten, 2008,1. Auflage ISBN 978-3-8322-7682-9
  Glander, H.-J., Grunewald, S., Paasch, U.
  
• Destabilization of acrosome and elastase influence mediate the release of secretory phospholipase A2 from human spermatozoa. Asian J. Androl. 10 (2008) 829-836
  Leßig, J.. Reibetanz, U., Arnhold, J.. Glander. H.-J.
  
• Influence of mediators of inflammation on sperm signalling, In: Biology of male germ cells. Shaker Verlag Aachen, Germany. Eds.: Glander, H.-J., Grunewald, S., Paasch. U. ISBN 978-3-8322-7682-9. 2008, 311-338.
  Leßig, J., Reibetanz, U., Salavei, P., Glander, H.-J., Arnhold, J.
  
• Non-vital polymorphonuclear leukocytes express myeloperoxidase on their surface. Cell. Physiol. Biochem. 21 (2008)287-296
  Flemmig, J., Leßig. J., Reibetanz, U., Dautel, P., Arnhold, J.
  
• Relationship between sperm apoptosis signalling and oocyte penetration capacity. Int. J. Androl. 31(3). 2008, 325-330
  Grunewald, S., Said, T.M., Paasch, U., Glander. H.-J., Agarwal, A.
  
• Resistin correlates with elastase and interleukin-6 in human seminal plasma. Reproductive BioMedicine Online, 16 (2008) 283-288
  Kratzsch, J., Paasch, U., Grunewald, S., Mueller, M.A., Thiery, J., Glander, H.-J.
  
• Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co- ordinated, controlled study of 791 men from Hamburg and Leipzig. Int J. Androl. 31(1) (2008) 93-102
  Paasch, U., Salzbrunn, A., Glander. H.J., Plambeck, K., Salzbrunn, H., Grunewald, S.. Stucke, J., Skakkebaek, N.E., Jorgensen, N.
  
• Stability of fluorochrome based assays to measure subcellular sperm functions. Asian J. Androl., 10(3) (2008) 455-459
  Grunewald, S., Rasch, M., Reinhardt, M., Baumann, T., Paasch, U.. Glander. H.-J.
  
• Utility of magnetic cell separation as a molecular sperm preparation technique. J. Androl. 2007 Dec 12 [Epub ahead of print], J Androl. 29 (2) (2008) 134-142
  Said, T.M.. Aganwal, A., Zborowski, M., Grunewald, S., Glander. H.-J., Paasch, U.
  
• Biology of Male Germ Cells, Shaker-Verlag, Aachen, 455 Seiten, 2009, 2. Auflage ISBN 978-3-8322-7685-0
  Glander, H.-J., Grunewald, S., Paasch, U.
  
• Impact of caspase activation in human spermatozoa. Microscopy Research and technique (Epub ahead of print) (2009)
  Grunewald, S., Sharma, R., Paasch, U., Glander, H.-J., Aganwal, A.
  
• Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. Fertil Steril. 92 (2009) 572-577
  Grunewald S, Reinhardt M, Blumenauer V, Said TM, Aganval A, Abu Hmeidan F, Glander HJ, Paasch U
  
• Interactions between apoptotic signal transduction and capacitation in human spermatozoa. Hum Reprod. 24 (2009) 2071-2078
  Grunewald S, Kriegel C, Baumann T, Glander HJ, Paasch U
  
• Modification of phosphatidylserine by hypochlorous acid. Chem. Phys. Lipids. 161 (2009) 44-50
  Flemmig, J., Spalteholz, H., Schubert, K.. Meier, S., Arnhold. J.
  
• Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysis. Curr. Med. Chem. 16 (2009) 2021-2041
  Lessig, J., Fuchs, B.
  
• Activity of nitric-oxide-synthetase (NOS) in mature and immature human spermatozoa. Andrologia (2009)
  Roessner, C., Grunewald, S., Paasch. U., Glander, H.-J.