Project Details
Projekt
Role of the splice target CAMK2D in RBM20 cardiomyopathy (A05)
Subject Area
Cardiology, Angiology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 464424253
Mutations in RBM20 cause a clinically aggressive form of dilated cardiomyopathy. RBM20 is a splicing factor that targets multiple cardiac genes, such as TTN and CAMK2D. Preliminary data shows that CAMK2D mediates cardiac dysfunction in RBM20 cardiomyopathy. Therefore, we ask how CAMK2D mediates RBM20 cardiomyopathy. We found that CAMK2D-dependent LMNA phosphorylation is increased in the hearts of Rbm20 knockout mice. Thus, we aim to elucidate the contribution of the CAMK2D-LMNA axis in RBM20 cardiomyopathy, and to identify antisense oligonucleotides (AONs) to knockdown specific Camk2d splice variants.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1550:
Molecular Circuits of Heart Disease
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Maarten van den Hoogenhof, Ph.D.
