Project Details
Projekt
Molecular and cellular mechanisms of persistent cortico-striatal motor dysfunction in mouse models of neurodevelopment disorders (B01)
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431549029
Project B01 explores the single-cell mechanisms behind persistent motor hyperactivity in a neurodevelopmental disorder mouse model. Building on the findings of altered striatal dopamine signalling and cortico-striatal communication imbalances as key factors, we aim to pinpoint the cellular and molecular drivers within these circuits in a new patient-derived mouse model. By integrating single-cell transcriptomics, CRISPR interventions, in vivo and in vitro recordings, and novel behavioral paradigms, project B01 seeks to detail the molecular and functional changes in these neurons, assessing their direct impact on motor dysfunction.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität zu Köln
Project Heads
Professor Dr. Dirk Isbrandt; Professor Dr. Jochen Roeper
