Neuronal mechanisms underlying motor flexibility in fruit fly walking (A05)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431549029

Project A05 investigates the neuronal mechanisms underlying locomotor flexibility using fruit fly as a model. Leveraging our discoveries on the proprioceptive signals for stepping control and the detailed map of ascending pathways and monoamine neurons, in the second funding period, project we use connectomics to map the synaptic connection points between sensory-, ascending-, descending- and leg control-neurons, identify specific monoamine neurons that modulate these points, and analyze their roles with optogenetics and 3D kinematic analysis. Thus, project A05 advances our understanding of monoamine neurons regulating motor flexibility.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1451: Key mechanisms of motor control in health and disease
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Ansgar Büschges; Professor Dr. Kei Ito