Deregulation of mTOR signaling pathways and metabolic reprogramming in VHL-dependent clear cell renal cell carcinoma (P13)

• Subject Area: Biochemistry ; Developmental Biology ; Nephrology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

P13 aims to unravel the epigenetic and metabolic dysregulation in VHL-mediated ccRCC by studying the interplay between VHL, prolyl hydroxylases, and mTOR signaling. New pVHL interaction partners will be investigated for their integral role in linking the mTOR pathway and lipid metabolic remodeling. RNA-sequencing data from ccRCCs of patients with VHL disease will be studied for pathway signatures and altered transcriptional programs using network analysis methods that allow the identification of features predictive of disease progression from high-dimensional datasets and the transfer of the learned information to similar transcriptomic datasets from hundreds of sporadic ccRCCs.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professorin Elke Neumann-Haefelin; Dr. Pascal Schlosser, since 1/2025; Professor Dr. Marc Timmers, until 12/2024