Structure and function of disease-relevant renal transport proteins (P10)

• Subject Area: Biochemistry ; Structural Biology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431984000

P10 will investigate solute carrier proteins (SLCs) that when mutated give rise to impaired kidney function and disease, such as SLC22A12 and SLC34A1, and their interaction partners like scaffolding proteins NHERF3 and NHERF1 in order to illuminate how specificity and modulation of affinity are achieved in the interaction of SLCs with promiscuous scaffold proteins. They propose a combined approach of biochemical, biophysical, and structural methods (cryo-EM, X-ray crystallography) to analyze the effects of kidney-function associated genetic variants in their cognate genes on the structure and function of renal SLCs, and to characterize the structures of SLCs relevant for genetic kidney diseases in their native and functional composition.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1453: Nephrogenetics (NephGen)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Carola Hunte