A functional genomics approach to understand inflammation in obesity (P19)

• Subject Area: Immunology ; Epidemiology and Medical Biometry/Statistics ; Medical Informatics and Medical Bioinformatics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

We revealed sex-dependent differences in the lipid metabolism and inflammatory status of obese individuals that contribute to the pathogenesis of atherosclerosis. Sex-dependent differences have also been observed in the metabolic syndrome associated with cardiovascular diseases, as well as during the immune aging process. We will now investigate the kinetics of immune aging in individuals with overweight and obesity compared with normal-weight individuals. We will further assess whether immune age acceleration is associated with metabolic and/or vascular complications in individuals with obesity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Mihai G. Netea; Katarzyna Placek, Ph.D.