Salt-induced metaflammation and consequences for antibacterial and autoinflammatory neutrophil responses (P14)

• Subject Area: Immunology ; Nephrology ; Cell Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432325352

A high salt diet (HSD) has been reported to promote inflammation, anti-infectious immunity and autoimmunity. We have observed that feeding mice a HSD aggravated a model of pyelonephritis, one of the most prevalent bacterial infections. In this project, we will (i) study the underlying cellular and molecular mechanisms; (ii) investigate whether HSD-induced mechanisms suppress a neutrophil-mediated form of autoimmunity, namely ANCA-associated vasculitis, and (iii) we will analyse in participants of the Rhineland Study, whether a HSD is connected with the incidence of bacterial infections or autoimmunity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1454: Metaflammation and Cellular Programming
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Christian Kurts